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Int Forum Allergy Rhinol:HLA-II基因与过敏性鼻炎的特异性免疫治疗结果相关

2019-08-03 AlexYang MedSci原创

治疗效果的关系,并评估了特异的多态性作为AIT受益AR患者生物标记的情况。研究包括了51名接受HDM AIT的中国AR患者。研究发现,等位基因DRB1*04:06; DRB1*14:05与鼻阻塞、鼻痒、眼痒和活动的改善具有正相关关系。相似的,DQB1*03:02:01; DQB1*05:03: 01与鼻阻塞、鼻痒、眼痒、行为问题和鼻症状评分具有正相关关系。 DRB1*03:01; DRB1*04:

治疗效果的关系,并评估了特异的多态性作为AIT受益AR患者生物标记的情况。

研究包括了51名接受HDM AIT的中国AR患者。研究发现,等位基因DRB1*04:06; DRB1*14:05与鼻阻塞、鼻痒、眼痒和活动的改善具有正相关关系。相似的,DQB1*03:02:01; DQB1*05:03: 01与鼻阻塞、鼻痒、眼痒、行为问题和鼻症状评分具有正相关关系。 DRB1*03:01; DRB1*04:06与鼻症状评分具有正相关关系。相反,DRB1*07:01:01; DRB1*11:01与非花粉症状、行为问题和鼻症状呈现负相关关系。

最后,研究人员指出,在HDM敏感的中国AR患者中,HLA-DRB1和HLA-DQB1基因多态性与AIT疗效相关。其中,DRB1*03:01、DRB1*04:06和DQB1*03:02:01以及DQB1*05:03:01也许可以作为有效AIT治疗AR患者的有用的生物标记。

原始出处:

Zhao Y, Zhao Y, Zhang Y et al. HLA-II genes are associated with outcomes of specific immunotherapy for allergic rhinitis. Int Forum Allergy Rhinol. 12 Jul 2019

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    2019-08-05 膀胱癌
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    2019-08-05 marongnuan
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