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bioRxiv:科学家首次在猫狗中发现新冠病毒变异毒株B.1.1.7

2021-03-22 MedSci原创 MedSci原创

随着全球新冠大流行,病毒突变频现。到目前为止,英国、南非、巴西、美国等国接连报告发现变异新冠病毒。而最早在英国发现的B.1.1.7变体,更易在人类之间传播,并具有更高的致命性。

随着全球新冠大流行,病毒突变频现。到目前为止,英国、南非、巴西、美国等国接连报告发现变异新冠病毒。而最早在英国发现的B.1.1.7变体,更易在人类之间传播,并具有更高的致命性。据数据显示,B.1.1.7变体占所有新感染病例的95%。

然而,到目前为止,尽管只有少数宠物对原始SARS-CoV-2的检测呈阳性,但B.1.1.7变体对宠物的影响尚不清楚。近日,一项新的研究中,研究人员在伦敦郊区拉尔夫兽医转诊中心发现,202012月到20212月,患有心肌炎的猫和狗的数量急剧增加,发生率从1.4%跃升至12.8%。而这与英国B.1.1.7变体的激增相吻合。

 

这些宠物均为曾有心脏病史,临床表现为嗜睡,食欲不振,呼吸急促/呼吸困难(继发于充血性心力衰竭),在某些情况下还包括晕厥事件。诊断研究表明存在心肌肌钙蛋白-I升高(中位数6.8;范围0.6861.1 ng / mL [正常参考范围0.0-0.2 ng / mL]),同时伴有心肌重塑的超声心动图证据和/或胸腔积液和/或肺水肿。经治疗后均取得了显着改善。然而,值得注意的是,这些宠物在生病3-6周前就其主人出现了Covid-19呼吸道症状,对主人进行Covid-19检测发现呈阳性。

为此,研究人员对患有心肌炎的8只猫和3只狗进行研究,收集了血清样本以及口/鼻咽和直肠拭子,并对其进行Covid-19检测。

研究发现,3只宠物Covid-19呈阳性,且均携带B.1.1.7变异毒株,有2只曾经感染过B.1.1.7变异毒株。有趣的是,所有这些B.1.1.7感染的宠物都具有非典型的临床表现。

研究人员表示,目前尚不清楚B.1.1.7在人和动物之间的传播能力是否强于原始毒株。虽然宠物成为感染源的风险仍然很低,但仍必须引起重视。

原始出处

Luca Ferasin.et.al.Myocarditis in naturally infected pets with the British variant of COVID-19.biorxiv.https://doi.org/10.1101/2021.03.18.435945

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    2021-08-05 sunylz
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    2021-03-23 病毒猎手

    #新冠病毒#这是人传动物,动物传人,病毒在不同物种中进行变异,有可能出现更大的灾难!!

    0

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    2021-03-22 公卫新人

    新冠肺炎,疫情何时才能消失

    0

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