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J Clin Periodontol:小型猪模型行上颌窦提升术:使用陶瓷和同种异体骨材料的影响

2017-10-13 MedSci MedSci原创

目前的临床中广泛依赖于现成的同种异体,异种或合成的骨生物材料以进行上颌窦提升。此外,已证明可吸收的胶原海绵(rhBMP-2 / ACS)中的重组人骨形态发生蛋白-2在上颌窦提升时支持临床相关骨的形成。

目前的临床中广泛依赖于现成的同种异体,异种或合成的骨生物材料以进行上颌窦提升。此外,已证明可吸收的胶原海绵(rhBMP-2 / ACS)中的重组人骨形态发生蛋白-2在上颌窦提升时支持临床相关骨的形成。

实验使用小型猪行上颌窦提升模型,植入两颗粒状骨生物材料后评估局部骨形成/种植体骨整合。

使用9只成年哥廷根小型猪来评估双相陶瓷(15%/ 85%HA /?-TCP)和同种异体矿化骨生物材料。随机分为对侧上颌窦部位的治疗包括假手术(对照)和生物材料。2个螺纹种植体(?4.0×11.5mm)置入每个上颌窦。在8周时将动物安乐死后用于组织学分析。手术方案的执行和愈合均正常。观察眶下肿胀直到缝合线拆除。双相陶瓷和同种异体骨生物材料的骨形成显着增加(5.2±1.9mm和4.9±1.6mm vs 2.6±0.5mm,p <0.05)和骨整合(18.0±6.0%和25.1±18.2% vs 10.1±8.0 %,p <0.05)。在生物材料之间没有观察到显着差异。

双相陶瓷或同种异体骨生物材料的植入增强了微型猪上颌窦的骨形成,然而,种植体骨支持不完全导致整体骨整合有限。

原始出处:

Cristiano Susin, et al. Sinus augmentation using a mini-pig model: Effect of ceramic and allogeneic bone biomaterials. Journal of Clinical Periodontology. 2017 October. doi: 10.1111/jcpe.12766

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    2018-01-24 feather89
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    2018-01-15 redcrab
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  5. [GetPortalCommentsPageByObjectIdResponse(id=2016502, encodeId=7046201650259, content=<a href='/topic/show?id=81602010295' target=_blank style='color:#2F92EE;'>#上颌窦提升术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20102, encryptionId=81602010295, topicName=上颌窦提升术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=139a316, createdName=wumeihua88, createdTime=Tue Dec 12 02:21:00 CST 2017, time=2017-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726802, encodeId=461e1e26802fa, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Jan 24 03:21:00 CST 2018, time=2018-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1776945, encodeId=fcc91e7694584, content=<a href='/topic/show?id=f757984131d' target=_blank style='color:#2F92EE;'>#陶瓷#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98413, encryptionId=f757984131d, topicName=陶瓷)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4d1639065122, createdName=redcrab, createdTime=Mon Jan 15 21:21:00 CST 2018, time=2018-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1798114, encodeId=fb931e98114ed, content=<a href='/topic/show?id=8e01681831e' target=_blank style='color:#2F92EE;'>#猪模型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68183, encryptionId=8e01681831e, topicName=猪模型)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/6F20312C71B4B22F603078C6DCFA72CE/100, createdBy=d3572500071, createdName=ms306040998833292, createdTime=Wed Mar 07 10:21:00 CST 2018, time=2018-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1687967, encodeId=1321168e96710, content=<a href='/topic/show?id=b3e73898423' target=_blank style='color:#2F92EE;'>#同种异体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38984, encryptionId=b3e73898423, topicName=同种异体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=23b928427427, createdName=12498768m22(暂无昵称), createdTime=Thu Jul 26 05:21:00 CST 2018, time=2018-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1555262, encodeId=3e7a1555262c5, content=<a href='/topic/show?id=f367681e434' target=_blank style='color:#2F92EE;'>#猪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68174, encryptionId=f367681e434, topicName=猪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9ec214601917, createdName=muzishouyi, createdTime=Sun Oct 15 05:21:00 CST 2017, time=2017-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1575266, encodeId=58c415e526602, content=<a href='/topic/show?id=0d3a20096d0' target=_blank style='color:#2F92EE;'>#上颌窦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20096, encryptionId=0d3a20096d0, topicName=上颌窦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cb4316082286, createdName=AspirantSuo, createdTime=Sun Oct 15 05:21:00 CST 2017, time=2017-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631122, encodeId=c7621631122ba, content=<a href='/topic/show?id=271b20090b0' target=_blank style='color:#2F92EE;'>#上颌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20090, encryptionId=271b20090b0, topicName=上颌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c07f21689347, createdName=hanhaisha2015, createdTime=Sun Oct 15 05:21:00 CST 2017, time=2017-10-15, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=2016502, encodeId=7046201650259, content=<a href='/topic/show?id=81602010295' target=_blank style='color:#2F92EE;'>#上颌窦提升术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20102, encryptionId=81602010295, topicName=上颌窦提升术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=139a316, createdName=wumeihua88, createdTime=Tue Dec 12 02:21:00 CST 2017, time=2017-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726802, encodeId=461e1e26802fa, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Jan 24 03:21:00 CST 2018, time=2018-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1776945, encodeId=fcc91e7694584, content=<a href='/topic/show?id=f757984131d' target=_blank style='color:#2F92EE;'>#陶瓷#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98413, encryptionId=f757984131d, topicName=陶瓷)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4d1639065122, createdName=redcrab, createdTime=Mon Jan 15 21:21:00 CST 2018, time=2018-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1798114, encodeId=fb931e98114ed, content=<a href='/topic/show?id=8e01681831e' target=_blank style='color:#2F92EE;'>#猪模型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68183, encryptionId=8e01681831e, topicName=猪模型)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/6F20312C71B4B22F603078C6DCFA72CE/100, createdBy=d3572500071, createdName=ms306040998833292, createdTime=Wed Mar 07 10:21:00 CST 2018, time=2018-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1687967, encodeId=1321168e96710, content=<a href='/topic/show?id=b3e73898423' target=_blank style='color:#2F92EE;'>#同种异体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38984, encryptionId=b3e73898423, topicName=同种异体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=23b928427427, createdName=12498768m22(暂无昵称), createdTime=Thu Jul 26 05:21:00 CST 2018, time=2018-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1555262, encodeId=3e7a1555262c5, content=<a href='/topic/show?id=f367681e434' target=_blank style='color:#2F92EE;'>#猪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68174, encryptionId=f367681e434, topicName=猪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9ec214601917, createdName=muzishouyi, createdTime=Sun Oct 15 05:21:00 CST 2017, time=2017-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1575266, encodeId=58c415e526602, content=<a href='/topic/show?id=0d3a20096d0' target=_blank style='color:#2F92EE;'>#上颌窦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20096, encryptionId=0d3a20096d0, topicName=上颌窦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cb4316082286, createdName=AspirantSuo, createdTime=Sun Oct 15 05:21:00 CST 2017, time=2017-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631122, encodeId=c7621631122ba, content=<a href='/topic/show?id=271b20090b0' target=_blank style='color:#2F92EE;'>#上颌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20090, encryptionId=271b20090b0, topicName=上颌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c07f21689347, createdName=hanhaisha2015, createdTime=Sun Oct 15 05:21:00 CST 2017, time=2017-10-15, status=1, ipAttribution=)]
    2017-10-15 muzishouyi
  7. [GetPortalCommentsPageByObjectIdResponse(id=2016502, encodeId=7046201650259, content=<a href='/topic/show?id=81602010295' target=_blank style='color:#2F92EE;'>#上颌窦提升术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20102, encryptionId=81602010295, topicName=上颌窦提升术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=139a316, createdName=wumeihua88, createdTime=Tue Dec 12 02:21:00 CST 2017, time=2017-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726802, encodeId=461e1e26802fa, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Jan 24 03:21:00 CST 2018, time=2018-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1776945, encodeId=fcc91e7694584, content=<a href='/topic/show?id=f757984131d' target=_blank style='color:#2F92EE;'>#陶瓷#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98413, encryptionId=f757984131d, topicName=陶瓷)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4d1639065122, createdName=redcrab, createdTime=Mon Jan 15 21:21:00 CST 2018, time=2018-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1798114, encodeId=fb931e98114ed, content=<a href='/topic/show?id=8e01681831e' target=_blank style='color:#2F92EE;'>#猪模型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68183, encryptionId=8e01681831e, topicName=猪模型)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/6F20312C71B4B22F603078C6DCFA72CE/100, createdBy=d3572500071, createdName=ms306040998833292, createdTime=Wed Mar 07 10:21:00 CST 2018, time=2018-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1687967, encodeId=1321168e96710, content=<a href='/topic/show?id=b3e73898423' target=_blank style='color:#2F92EE;'>#同种异体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38984, encryptionId=b3e73898423, topicName=同种异体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=23b928427427, createdName=12498768m22(暂无昵称), createdTime=Thu Jul 26 05:21:00 CST 2018, time=2018-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1555262, encodeId=3e7a1555262c5, content=<a href='/topic/show?id=f367681e434' target=_blank style='color:#2F92EE;'>#猪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68174, encryptionId=f367681e434, topicName=猪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9ec214601917, createdName=muzishouyi, createdTime=Sun Oct 15 05:21:00 CST 2017, time=2017-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1575266, encodeId=58c415e526602, content=<a href='/topic/show?id=0d3a20096d0' target=_blank style='color:#2F92EE;'>#上颌窦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20096, encryptionId=0d3a20096d0, topicName=上颌窦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cb4316082286, createdName=AspirantSuo, createdTime=Sun Oct 15 05:21:00 CST 2017, time=2017-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631122, encodeId=c7621631122ba, content=<a href='/topic/show?id=271b20090b0' target=_blank style='color:#2F92EE;'>#上颌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20090, encryptionId=271b20090b0, topicName=上颌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c07f21689347, createdName=hanhaisha2015, createdTime=Sun Oct 15 05:21:00 CST 2017, time=2017-10-15, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=2016502, encodeId=7046201650259, content=<a href='/topic/show?id=81602010295' target=_blank style='color:#2F92EE;'>#上颌窦提升术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20102, encryptionId=81602010295, topicName=上颌窦提升术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=139a316, createdName=wumeihua88, createdTime=Tue Dec 12 02:21:00 CST 2017, time=2017-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726802, encodeId=461e1e26802fa, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Wed Jan 24 03:21:00 CST 2018, time=2018-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1776945, encodeId=fcc91e7694584, content=<a href='/topic/show?id=f757984131d' target=_blank style='color:#2F92EE;'>#陶瓷#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=98413, encryptionId=f757984131d, topicName=陶瓷)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4d1639065122, createdName=redcrab, createdTime=Mon Jan 15 21:21:00 CST 2018, time=2018-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1798114, encodeId=fb931e98114ed, content=<a href='/topic/show?id=8e01681831e' target=_blank style='color:#2F92EE;'>#猪模型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68183, encryptionId=8e01681831e, topicName=猪模型)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/6F20312C71B4B22F603078C6DCFA72CE/100, createdBy=d3572500071, createdName=ms306040998833292, createdTime=Wed Mar 07 10:21:00 CST 2018, time=2018-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1687967, encodeId=1321168e96710, content=<a href='/topic/show?id=b3e73898423' target=_blank style='color:#2F92EE;'>#同种异体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38984, encryptionId=b3e73898423, topicName=同种异体)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=23b928427427, createdName=12498768m22(暂无昵称), createdTime=Thu Jul 26 05:21:00 CST 2018, time=2018-07-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1555262, encodeId=3e7a1555262c5, content=<a href='/topic/show?id=f367681e434' target=_blank style='color:#2F92EE;'>#猪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68174, encryptionId=f367681e434, topicName=猪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9ec214601917, createdName=muzishouyi, createdTime=Sun Oct 15 05:21:00 CST 2017, time=2017-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1575266, encodeId=58c415e526602, content=<a href='/topic/show?id=0d3a20096d0' target=_blank style='color:#2F92EE;'>#上颌窦#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20096, encryptionId=0d3a20096d0, topicName=上颌窦)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cb4316082286, createdName=AspirantSuo, createdTime=Sun Oct 15 05:21:00 CST 2017, time=2017-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631122, encodeId=c7621631122ba, content=<a href='/topic/show?id=271b20090b0' target=_blank style='color:#2F92EE;'>#上颌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20090, encryptionId=271b20090b0, topicName=上颌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c07f21689347, createdName=hanhaisha2015, createdTime=Sun Oct 15 05:21:00 CST 2017, time=2017-10-15, status=1, ipAttribution=)]
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