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Neurology:睡眠时间超八小时更易脑中风?

2015-03-03 林菲菲 “医学界杂志”微信号

有句话说“吃洋参、不如睡五更”,但近日一项来自剑桥大学的研究提示,“睡五更”(10个小时)也许是一种不健康的生活方式。 研究表明,夜间睡眠时长超过8小时的人,将面临更高的脑卒中风险,该研究于2月25日在线发表于Neurology。 研究共纳入9692名年龄在42-81岁的调查对象,进行为期9.5年的前瞻性队列研究,记录调查对象的睡眠模式和脑卒中的发病情况。同时,对Ovid Medlin

有句话说“吃洋参、不如睡五更”,但近日一项来自剑桥大学的研究提示,“睡五更”(10个小时)也许是一种不健康的生活方式。

研究表明,夜间睡眠时长超过8小时的人,将面临更高的脑卒中风险,该研究于2月25日在线发表于Neurology。

研究共纳入9692名年龄在42-81岁的调查对象,进行为期9.5年的前瞻性队列研究,记录调查对象的睡眠模式和脑卒中的发病情况。同时,对Ovid Medline、EMBASE、Cochrane Library数据库中的相关文献进行meta分析。

结果发现,在调整了常规的心脑血管疾病危险因素后,长时间睡眠,即超过8小时睡眠的人群中,发生脑卒中的风险增加46%。其中长期维持长时间睡眠者脑卒中风险更高,是维持平均睡眠时长者的2倍。

Meta分析显示,在小于6小时睡眠的人群中,脑卒中风险增加15%--看到这里,熬夜党们是不是乐坏了?少睡真的比睡过头好?遗憾的是,研究结果还显示,睡眠模式不稳定的人,脑卒中风险骤增,是维持6-8小时睡眠者的4倍!这里的睡眠模式改变指在4年中,从少于6小时睡眠时长跳转到大于8小时睡眠时长。研究中,睡眠模式改变主要发生在老年人群中(小编按:那些平时熬夜加班,周末狂睡不起的人,也许同样需要注意了哈)。

研究人员Leng表示,目前他们还不认为长时间睡眠是导致脑卒中的原因,但前者是脑卒中风险增加的一个信号。医生们通过询问病人的睡眠时长,以及在近几年中睡眠时长是否发生改变,可进一步确认病人发生中风的风险,如睡眠时长从5-6小时跳转到9-10小时者,尤其是在老年人群中,即使血压等指标控制良好者,仍是需要警惕的高危人群。

此前已有不少研究提示睡眠时长和脑卒中之间的关联,但目前研究人员还无法就这一结果给出解释。睡眠会影响体内激素分泌的水平,进而影响血压,不过,当研究组控制了血压因素后,发现睡眠时长和脑卒中之间的关系依旧存在。此前Leng的一项研究发现,习惯午睡的人群中,血清中的C反应蛋白(一种炎症、免疫相关蛋白)偏高,提示睡眠模式会影响免疫系统的反应。

值得一提的是,这是位中国学子在剑桥做的研究,文章第一作者Leng已就睡眠相关问题发表多篇SCI。看到这里,你是不是跃跃欲试了?科研并非都是严肃的实验,好玩的、贴近生活的问题,往往也是很好的科研课题。不过,忙于科研和临床的同时,别忘了保证健康的睡眠模式哈。

原始出处:


Leng Y1, Cappuccio FP2, Wainwright NW2, Surtees PG2, Luben R2, Brayne C2, Khaw KT2.Sleep duration and risk of fatal and nonfatal stroke: A prospective study and meta-analysis.Neurology. 2015 Feb 25. pii: 10.1212/WNL.0000000000001371. [Epub ahead of print]

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1999508, encodeId=199e199950825, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Mon Apr 13 01:26:00 CST 2015, time=2015-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17520, encodeId=7f121e520d2, content=真不错,好像又有一点新的课题思路了, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=zhouanxiu, createdTime=Tue Mar 03 21:39:00 CST 2015, time=2015-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17516, encodeId=1a461e516d3, content=过高过低都不好, beContent=null, objectType=article, channel=null, level=null, likeNumber=170, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Tue Mar 03 19:55:00 CST 2015, time=2015-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17513, encodeId=319f1e513c0, content=有趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f401615413, createdName=慧读, createdTime=Tue Mar 03 19:48:00 CST 2015, time=2015-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17514, encodeId=75501e514d8, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f401615413, createdName=慧读, createdTime=Tue Mar 03 19:48:00 CST 2015, time=2015-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17511, encodeId=cce61e51198, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=MedSci客户端网友, createdTime=Tue Mar 03 19:45:00 CST 2015, time=2015-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17512, encodeId=46a91e512e3, content=有价值, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=MedSci客户端网友, createdTime=Tue Mar 03 19:45:00 CST 2015, time=2015-03-03, status=1, ipAttribution=)]
    2015-04-13 yinhl1978
  2. [GetPortalCommentsPageByObjectIdResponse(id=1999508, encodeId=199e199950825, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Mon Apr 13 01:26:00 CST 2015, time=2015-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17520, encodeId=7f121e520d2, content=真不错,好像又有一点新的课题思路了, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=zhouanxiu, createdTime=Tue Mar 03 21:39:00 CST 2015, time=2015-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17516, encodeId=1a461e516d3, content=过高过低都不好, beContent=null, objectType=article, channel=null, level=null, likeNumber=170, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Tue Mar 03 19:55:00 CST 2015, time=2015-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17513, encodeId=319f1e513c0, content=有趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f401615413, createdName=慧读, createdTime=Tue Mar 03 19:48:00 CST 2015, time=2015-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17514, encodeId=75501e514d8, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f401615413, createdName=慧读, createdTime=Tue Mar 03 19:48:00 CST 2015, time=2015-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17511, encodeId=cce61e51198, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=MedSci客户端网友, createdTime=Tue Mar 03 19:45:00 CST 2015, time=2015-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17512, encodeId=46a91e512e3, content=有价值, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=MedSci客户端网友, createdTime=Tue Mar 03 19:45:00 CST 2015, time=2015-03-03, status=1, ipAttribution=)]
    2015-03-03 zhouanxiu

    真不错,好像又有一点新的课题思路了

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1999508, encodeId=199e199950825, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Mon Apr 13 01:26:00 CST 2015, time=2015-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17520, encodeId=7f121e520d2, content=真不错,好像又有一点新的课题思路了, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=zhouanxiu, createdTime=Tue Mar 03 21:39:00 CST 2015, time=2015-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17516, encodeId=1a461e516d3, content=过高过低都不好, beContent=null, objectType=article, channel=null, level=null, likeNumber=170, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Tue Mar 03 19:55:00 CST 2015, time=2015-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17513, encodeId=319f1e513c0, content=有趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f401615413, createdName=慧读, createdTime=Tue Mar 03 19:48:00 CST 2015, time=2015-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17514, encodeId=75501e514d8, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f401615413, createdName=慧读, createdTime=Tue Mar 03 19:48:00 CST 2015, time=2015-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17511, encodeId=cce61e51198, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=MedSci客户端网友, createdTime=Tue Mar 03 19:45:00 CST 2015, time=2015-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17512, encodeId=46a91e512e3, content=有价值, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=MedSci客户端网友, createdTime=Tue Mar 03 19:45:00 CST 2015, time=2015-03-03, status=1, ipAttribution=)]
    2015-03-03 medcardio

    过高过低都不好

    0

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    2015-03-03 慧读

    有趣

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1999508, encodeId=199e199950825, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Mon Apr 13 01:26:00 CST 2015, time=2015-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17520, encodeId=7f121e520d2, content=真不错,好像又有一点新的课题思路了, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=zhouanxiu, createdTime=Tue Mar 03 21:39:00 CST 2015, time=2015-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17516, encodeId=1a461e516d3, content=过高过低都不好, beContent=null, objectType=article, channel=null, level=null, likeNumber=170, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Tue Mar 03 19:55:00 CST 2015, time=2015-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17513, encodeId=319f1e513c0, content=有趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f401615413, createdName=慧读, createdTime=Tue Mar 03 19:48:00 CST 2015, time=2015-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17514, encodeId=75501e514d8, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f401615413, createdName=慧读, createdTime=Tue Mar 03 19:48:00 CST 2015, time=2015-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17511, encodeId=cce61e51198, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=MedSci客户端网友, createdTime=Tue Mar 03 19:45:00 CST 2015, time=2015-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17512, encodeId=46a91e512e3, content=有价值, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=MedSci客户端网友, createdTime=Tue Mar 03 19:45:00 CST 2015, time=2015-03-03, status=1, ipAttribution=)]
    2015-03-03 慧读

    有意思

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1999508, encodeId=199e199950825, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Mon Apr 13 01:26:00 CST 2015, time=2015-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17520, encodeId=7f121e520d2, content=真不错,好像又有一点新的课题思路了, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=zhouanxiu, createdTime=Tue Mar 03 21:39:00 CST 2015, time=2015-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17516, encodeId=1a461e516d3, content=过高过低都不好, beContent=null, objectType=article, channel=null, level=null, likeNumber=170, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Tue Mar 03 19:55:00 CST 2015, time=2015-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17513, encodeId=319f1e513c0, content=有趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f401615413, createdName=慧读, createdTime=Tue Mar 03 19:48:00 CST 2015, time=2015-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17514, encodeId=75501e514d8, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f401615413, createdName=慧读, createdTime=Tue Mar 03 19:48:00 CST 2015, time=2015-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17511, encodeId=cce61e51198, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=MedSci客户端网友, createdTime=Tue Mar 03 19:45:00 CST 2015, time=2015-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17512, encodeId=46a91e512e3, content=有价值, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=MedSci客户端网友, createdTime=Tue Mar 03 19:45:00 CST 2015, time=2015-03-03, status=1, ipAttribution=)]
    2015-03-03 MedSci客户端网友

    有意思

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1999508, encodeId=199e199950825, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Mon Apr 13 01:26:00 CST 2015, time=2015-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17520, encodeId=7f121e520d2, content=真不错,好像又有一点新的课题思路了, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=zhouanxiu, createdTime=Tue Mar 03 21:39:00 CST 2015, time=2015-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17516, encodeId=1a461e516d3, content=过高过低都不好, beContent=null, objectType=article, channel=null, level=null, likeNumber=170, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Tue Mar 03 19:55:00 CST 2015, time=2015-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17513, encodeId=319f1e513c0, content=有趣, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f401615413, createdName=慧读, createdTime=Tue Mar 03 19:48:00 CST 2015, time=2015-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17514, encodeId=75501e514d8, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7f401615413, createdName=慧读, createdTime=Tue Mar 03 19:48:00 CST 2015, time=2015-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17511, encodeId=cce61e51198, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=MedSci客户端网友, createdTime=Tue Mar 03 19:45:00 CST 2015, time=2015-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=17512, encodeId=46a91e512e3, content=有价值, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=MedSci客户端网友, createdTime=Tue Mar 03 19:45:00 CST 2015, time=2015-03-03, status=1, ipAttribution=)]
    2015-03-03 MedSci客户端网友

    有价值

    0

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