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J Periodontal Res：可溶性环氧水解酶抑制剂促进免疫调节抑制骨吸收

2018-10-01 MedSci MedSci原创

可溶性环氧水解酶抑制剂A.a牙槽骨吸收
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可溶性环氧水解酶抑制剂

可溶性环氧化物水解酶（sEH）是花生四烯酸级联中的一种酶，其将环氧脂肪酸（EpFAs）（例如由细胞色素P450酶产生的环氧二十碳三烯酸（EET））转化为二羟基 - 二十碳三烯酸。在过去的20年中，随着sEH抑制剂的发展，在体内模型中提高EET和其他EpFAs的水平已经成为可能。最近有研究表明，EET在骨吸收过程中抑制炎症方面起着关键作用，但其机制尚不清楚。在目前的研究中，我们使用sEH抑制剂（1-三氟甲氧基苯基-3-（1-丙酰基哌啶-4-基）脲[TPPU]）来研究小鼠牙周炎模型中的免疫调节作用。

方法：在第0天，第2天和第4天时，用伴放线放线杆菌感染小鼠，并将其分组（n = 6），每天口服1mg / kg TPPU治疗，共15天。然后，处死小鼠并使用形态测定法分析它们的颌骨的骨吸收。通过微阵列PCR或蛋白质印迹分析牙龈组织中的免疫炎性标记物。

结果：用TPPU处理的感染小鼠比未经处理的感染小鼠骨吸收更低。并且，感染小鼠sEH的表达增加；然而，TPPU治疗的小鼠sEH表达降低。此外，在用1mg / kg TPPU处理的组中，几种促炎细胞因子和分子标记物在牙龈组织中下调。

sEH抑制剂TPPU在骨吸收小鼠模型中具有免疫调节作用，可以抑制骨吸收和炎症反应。

原始出处：

M. H. Napimoga， et al.Soluble epoxide hydrolase inhibitor promotes immunomodulation to inhibit bone resorption. Journal of  Periodontal Research. 2018 October. Doi：10.1111/jre.12559

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    2019-04-01 jklm09

    #抑制剂#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1851806, encodeId=a87c185180677, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Mon Apr 01 13:18:00 CST 2019, time=2019-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727637, encodeId=7b951e27637fa, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Sep 01 16:18:00 CST 2019, time=2019-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=348349, encodeId=588f348349c2, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sun Oct 07 11:01:45 CST 2018, time=2018-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532600, encodeId=83c2153260037, content=<a href='/topic/show?id=75991016300c' target=_blank style='color:#2F92EE;'>#骨吸收#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101630, encryptionId=75991016300c, topicName=骨吸收)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74d112366079, createdName=徐岩, createdTime=Wed Oct 03 07:18:00 CST 2018, time=2018-10-03, status=1, ipAttribution=)]
    2019-09-01 feather89

    #PE#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1851806, encodeId=a87c185180677, content=<a href='/topic/show?id=f0a254918f0' target=_blank style='color:#2F92EE;'>#抑制剂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54918, encryptionId=f0a254918f0, topicName=抑制剂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=44a360, createdName=jklm09, createdTime=Mon Apr 01 13:18:00 CST 2019, time=2019-04-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727637, encodeId=7b951e27637fa, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Sep 01 16:18:00 CST 2019, time=2019-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=348349, encodeId=588f348349c2, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sun Oct 07 11:01:45 CST 2018, time=2018-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532600, encodeId=83c2153260037, content=<a href='/topic/show?id=75991016300c' target=_blank style='color:#2F92EE;'>#骨吸收#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101630, encryptionId=75991016300c, topicName=骨吸收)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74d112366079, createdName=徐岩, createdTime=Wed Oct 03 07:18:00 CST 2018, time=2018-10-03, status=1, ipAttribution=)]
    2018-10-07 wxl882001

    学习一下

    0

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    2018-10-03 徐岩

    #骨吸收#

    0

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