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Heart:高龄感染性心内膜炎患者有何不同?

2017-04-22 xing.T MedSci原创

由此可见,高龄患者的IE是一个与年轻人有所不同的疾病,肠球菌是最常见的感染微生物,并且死亡率较年轻的患者要高。ESC建议高龄患者进行手术治疗要比年轻患者少,导致了有手术适应症的患者没有手术而死亡率急剧增加,而手术患者预后良好。这些结果表明手术在高龄IE患者中没有被充分利用。

近日,在心脏病领域权威杂志Heart上发表了一篇研究文章,研究人员旨在描述高龄感染性心内膜炎(IE)患者的临床特征,并且进一步评估这些患者的预后。

研究人员将于2008年7月至2013年7月期间在转诊中心被明确诊断为IE的患者前瞻性地纳入研究,并将454例患者随机分为三组:230例患者65岁以下,173例患者65-80岁,51例患者大于80岁。该研究的主要终点为1年死亡率。

研究人员发现1年死亡率在大于80岁组的患者中较高的(37.3%),相比于小于65 岁组患者(13%;P<0.001)和65-80岁组(19.7%;P=0.009)。肠球菌和解没食子酸链球菌是更频繁的感染微生物。在抗生素治疗情况下发生栓塞(n=11(21.6%),P=0.03)和肾功能衰竭(n=23(51%),P=0.004)在大于80 岁组的患者中更为频繁。在大于80岁组患者中,38例患者有手术理论指症。在16个手术的患者中死亡率较低(6.3%),但在22例没有手术的患者中,则非常高(72.7%)。即使高龄患者不经常考虑进行手术治疗,但术后的生存率是与年轻患者一样优良(分别为93.7%、89.9%和90.4%),而不进行手术与预后很差相关。

由此可见,高龄患者的IE是一个与年轻人有所不同的疾病,肠球菌是最常见的感染微生物,并且死亡率较年轻的患者要高。ESC建议高龄患者进行手术治疗要比年轻患者少,导致了有手术适应症的患者没有手术而死亡率急剧增加,而手术患者预后良好。这些结果表明手术在高龄IE患者中没有被充分利用。

原始出处:

Léopold Oliver,et al. Infective endocarditis in octogenarians. Heart. 2017. http://dx.doi.org/10.1136/heartjnl-2016-310853

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    2017-04-25 ylzr123

    感谢小编为我们精心准备了如此精辟的精神大餐,小编辛苦了,点个赞吧!

    0

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1708368, encodeId=68b11e0836898, content=<a href='/topic/show?id=4c2d3051535' target=_blank style='color:#2F92EE;'>#内膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30515, encryptionId=4c2d3051535, topicName=内膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=730431558473, createdName=12498974m61暂无昵称, createdTime=Sun Sep 17 12:00:00 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655373, encodeId=0d0f16553e3e6, content=<a href='/topic/show?id=7c2853311ac' target=_blank style='color:#2F92EE;'>#感染性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53311, encryptionId=7c2853311ac, topicName=感染性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=583d24724321, createdName=charl1234575, createdTime=Thu Jan 11 03:00:00 CST 2018, time=2018-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190332, encodeId=6a27190332d3, content=感谢小编为我们精心准备了如此精辟的精神大餐,小编辛苦了,点个赞吧!, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Apr 25 05:33:38 CST 2017, time=2017-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350683, encodeId=b1631350683ac, content=<a href='/topic/show?id=a32d508e8c3' target=_blank style='color:#2F92EE;'>#心内膜炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50878, encryptionId=a32d508e8c3, topicName=心内膜炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Apr 24 02:00:00 CST 2017, time=2017-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356228, encodeId=6f4313562281f, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Mon Apr 24 02:00:00 CST 2017, time=2017-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416051, encodeId=6e401416051aa, content=<a href='/topic/show?id=99fb1028231b' target=_blank style='color:#2F92EE;'>#高龄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102823, encryptionId=99fb1028231b, topicName=高龄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=307c3130149, createdName=xlysu, createdTime=Mon Apr 24 02:00:00 CST 2017, time=2017-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562486, encodeId=0d18156248629, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Mon Apr 24 02:00:00 CST 2017, time=2017-04-24, status=1, ipAttribution=)]
    2017-04-24 爆笑小医
  6. [GetPortalCommentsPageByObjectIdResponse(id=1708368, encodeId=68b11e0836898, content=<a href='/topic/show?id=4c2d3051535' target=_blank style='color:#2F92EE;'>#内膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30515, encryptionId=4c2d3051535, topicName=内膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=730431558473, createdName=12498974m61暂无昵称, createdTime=Sun Sep 17 12:00:00 CST 2017, time=2017-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655373, encodeId=0d0f16553e3e6, content=<a href='/topic/show?id=7c2853311ac' target=_blank style='color:#2F92EE;'>#感染性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53311, encryptionId=7c2853311ac, topicName=感染性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=583d24724321, createdName=charl1234575, createdTime=Thu Jan 11 03:00:00 CST 2018, time=2018-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=190332, encodeId=6a27190332d3, content=感谢小编为我们精心准备了如此精辟的精神大餐,小编辛苦了,点个赞吧!, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Apr 25 05:33:38 CST 2017, time=2017-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1350683, encodeId=b1631350683ac, content=<a href='/topic/show?id=a32d508e8c3' target=_blank style='color:#2F92EE;'>#心内膜炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50878, encryptionId=a32d508e8c3, topicName=心内膜炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Apr 24 02:00:00 CST 2017, time=2017-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1356228, encodeId=6f4313562281f, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Mon Apr 24 02:00:00 CST 2017, time=2017-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1416051, encodeId=6e401416051aa, content=<a href='/topic/show?id=99fb1028231b' target=_blank style='color:#2F92EE;'>#高龄#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102823, encryptionId=99fb1028231b, topicName=高龄)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=307c3130149, createdName=xlysu, createdTime=Mon Apr 24 02:00:00 CST 2017, time=2017-04-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562486, encodeId=0d18156248629, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Mon Apr 24 02:00:00 CST 2017, time=2017-04-24, status=1, ipAttribution=)]
    2017-04-24 xlysu
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    2017-04-24 slcumt

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