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Diabetes:1型糖尿病儿童大脑发育中的代偿性连接增加!

2017-03-12 xing.T MedSci原创

总之,该研究试图填补了1型糖尿病血糖代谢异常如何影响儿童时期大脑内在连接的关键知识空白。

1型糖尿病相关的持续的血糖失调(高血糖或低血糖)与认知功能障碍和大脑解剖结构的改变以及连接相关。然而,至于1型糖尿病如何影响青年发育中的大脑自发的静息连接仍不清楚。近日,糖尿病领域权威杂志Diabetes上针对这一问题发表了一篇研究文章。

在这个大型的多中心研究中,研究人员采用1型糖尿病儿童(n=57;平均年龄为7.88岁;女性有27例)与年龄匹配的无糖尿病对照受试者(n=26;平均年龄为7.43岁;女性有14例)的静息态fMRI数据进行分析。使用模型驱动的种子基础分析和模型无关的独立组分分析,并且调整年龄、数据采集网站和性别,得到合并的结果提示1型糖尿病儿童脑内的连接相比于无糖尿病的对照组有所增加。


此外,研究人员观察到1型糖尿病儿童脑内连接的增加与认知功能呈正相关。所观察到的1型糖尿病儿童脑内连接与认知功能之间的正相关,在认知功能上无整体的组间差异,表明1型糖尿病儿童脑内固有连接存在假定的代偿作用。

总之,该研究试图填补了1型糖尿病血糖代谢异常如何影响儿童时期大脑内在连接的关键知识空白。

原始出处:

Manish Saggar, et al. Compensatory Hyperconnectivity in Developing Brains of Young Children With Type 1 Diabetes. Diabetes 2017 Mar; 66(3): 754-762. https://doi.org/10.2337/db16-0414

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    2017-07-12 爆笑小医
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    2017-03-14 neurowu
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