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盘点:2018年1月13日Lancet研究精选

2018-01-12 zhangfan MedSci原创

2018年1月13日Lancet研究精选



【1】儿童与社交媒体


社交媒体是人们生活中日益普遍和不可或缺的一部分,目前大部分社交平台规定的儿童访问年龄为13岁。近日来自英国的Anne Longfield对8-12岁的儿童媒体体验过程进行了研究。

16名男孩和16名女孩参与研究。研究人员考察了儿童如何获取和使用社交媒体,它带来的快乐和悲伤,与同龄人的在线互动,以及儿童从小学到中学的使用媒体方式的演变。儿童反映社交媒体很有趣,激发了创造力,强化了人际关系,特别是与远房亲戚和朋友的关系,尽管面对面的接触仍然十分重要。

统计发现,18岁以下人群约占互联网用户的1/3。线下交流是一种更邻人感到自然的接触方式。在社交媒体家庭小组的推动下,年龄较大的儿童的学习机会增加。对于那些感到被移民、残疾或性行为边缘化的人,社交媒体提供了获取信息的途径,并引入了更多的同龄人。同时社交媒体塑造态度、价值观和行为能力--特别是在弱势群体中--既有积极的影响,也有消极的影响。

为确保儿童不受不良社交媒体的侵害,研究人员认为应当禁止孩子进入父母的社交媒体账户,通过成人账户,儿童可能接触到不恰当的语言和主题;同时父母应减少分享孩子的照片--许多孩子觉得这种行为使他们痛苦,但却无力反抗。减少不良内容对儿童的侵害需要政府、学校和家庭的共同参与。

需要更多的措施保护儿童免受不良信息的侵蚀。首先,应为儿童用户提供一个安全、礼教、文明的网络或严格的遵守年龄限制条款;其次,对于任何年龄的用户来说,现有条款似乎是难以理解的,应该清楚而简洁地提出相应条款,以便年龄较小的用户能够真正的知情同意;第三,相关公司应该大力维用户护隐私权,特别是年轻人;第四,应强化个人对社交媒体的管理,删除不适合内容;最后,必须鼓励相关公司提供更安全、友好和健康的社交媒体平台。

【2】延迟氨甲环酸抗纤溶药物治疗显著降低急性重症出血患者生存率


抗纤溶药物可减少创伤出血和产后出血导致的死亡。近日研究人员考察了延迟抗纤溶治疗对创伤出血和产后出血患者生存率的影响。

本研究为荟萃分析研究,研究人员统计了1946-2017年间的相关资料,急性严重出血患者人数超过1000例的抗纤溶药物随机试验有资格纳入本次研究。研究的主要终点是出血死亡

2项氨甲环酸用于急性出血(创伤和产后出血)的临床研究纳入本次荟萃分析,总计40138名患者,共发生了3558例患者死亡事件,其中40%的患者死于失血。大部分(884 /1408 [63%])出血患者在症状发生后12小时死亡,产后出血死亡率在胎儿娩出后2-3小时达到峰值。研究发现,氨甲环酸可显著降低总的出血死亡率(OR 1.20, 95% CI 1.08-1.33; p=0.001),其效果不受出血位置的影响。延迟治疗导致治疗收益降低。即刻治疗可提高70%的生存率(OR 1.72,95% CI 1.42-2.10)。出血症状发生3小时内,治疗每延迟15分钟,患者的生存率下降10%,3小时后治疗无临床意义。氨甲环酸不会增加血栓风险且不受出血位置的影响,延迟治疗不会影响氨甲环酸对血栓事件的效果。

【3】早期进食方式对重症患者预后的影响


近日研究人员考察了早期进食方式对危重患者预后的影响。

NUTRIREA-2研究在法国44个重症监护中心开展,接受有创机械通气和升压治疗的休克患者参与。患者随机在插管后24小时进行肠外或肠内营养补充,目标剂量为20-25 kcal/kg/d。研究的主要终点是28天内死亡率。

研究在第二次中期分析后终止,总计2410名患者参与,其中肠内营养组1202人,肠外营养组1208人。28天后,443名 (37%)肠内营养组和422名(35%)肠外营养组患者死亡,差异为2%。组间ICU获得性感染的累积发病率无显著差异(14% vs 16%)。相比于肠外营养组,肠内营养组患者呕吐(406 例[34%] vs 246例 [20%]; HR 1.89 [1.62-2.20])、腹泻(432例[36%] vs 393例[33%]; 1.20 [1.05-1.37])、肠道缺血 (19例 [2%] vs5例[<1%]; 3.84 [1.43-10.3])以及急性假性结肠梗阻(11例 [1%] vs3例[<1%]; 3.7 [1.03-13.2)的累积发病率更高。

研究认为,对于危重休克患者,与早期肠外营养相比,肠内营养补充不能降低死亡率或继发感染的风险,反而会增加更大的消化并发症风险。

【4】口服非昔硝唑对晚期非洲锥虫病有效


布氏锥虫(G-HAT)引起的非洲锥虫病,其晚期治疗手段十分有限。一线治疗方法--口服尼弗替莫和静脉注射依氟尼汀的联合治疗必须在医院中开展,对于医疗资源匮乏的非洲地区难以实现。近日研究人员考察了非昔硝唑对晚期非洲锥虫病的治疗效果。

15岁以上的晚期非洲锥虫病患者随机接受非昔硝唑或弗替莫+依氟尼汀联合治疗。非昔硝唑每天1次(1-4d,每天1800mg;5-10d每天1200mg)。弗替莫每天3次(15mg/Kg)+依氟尼汀每天2次(400mg/Kg)。主要终点是治疗成功率。

394人接受研究,其中非昔硝唑组264人,标准治疗组130人。治疗成功率如下:非昔硝唑组,91%,标准治疗组98%,达到非劣性终点。组间不良事件差异不显著(81% vs 79%)。

研究认为口服非昔硝唑是有效的晚期非洲锥虫病治疗方法。

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    2018-04-08 howi
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    2018-01-28 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

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    2018-01-21 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

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    2018-01-19 zwjnj2

    好好好好学习天天向上

    0

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    2018-01-17 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

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    2018-01-16 海之蓝

    学习

    0

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    2018-01-14 虈亣靌

    谢谢分享.学习了

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1829423, encodeId=9250182942382, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sun Apr 08 10:42:00 CST 2018, time=2018-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282772, encodeId=3893282e72ee, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Jan 28 07:05:21 CST 2018, time=2018-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280581, encodeId=34c628058152, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Jan 21 08:28:35 CST 2018, time=2018-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280103, encodeId=584c280103ed, content=好好好好学习天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQpl0ENSJScphsFtdgfibXX1g1IuEYGCjP23UqCd52TxTpSZibtPiclyusaHicnNXd78alaia19Qy1nAFo18/0, createdBy=50381491660, createdName=zwjnj2, createdTime=Fri Jan 19 18:31:07 CST 2018, time=2018-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279266, encodeId=d67d2e9266a1, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Wed Jan 17 06:38:23 CST 2018, time=2018-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279202, encodeId=225b2e9202fd, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJpBl6xwMmnsKibwxcAIltOH3nnCEQbNE6TDbYtCKe8hYI0oJrbduNqnJraM1PyyjPKU1suAzicYPaA/132, createdBy=eeaf2031798, createdName=海之蓝, createdTime=Tue Jan 16 21:39:43 CST 2018, time=2018-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278458, encodeId=0db72e84580b, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Jan 14 13:56:07 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278342, encodeId=59082e83426f, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sun Jan 14 08:17:54 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278289, encodeId=88e72e828969, content=学习了.谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sun Jan 14 06:11:16 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278195, encodeId=b3cf2e8195bc, content=了解了解.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sat Jan 13 20:43:52 CST 2018, time=2018-01-13, status=1, ipAttribution=)]
    2018-01-14 大爰

    学习了谢谢分享!!

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1829423, encodeId=9250182942382, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sun Apr 08 10:42:00 CST 2018, time=2018-04-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=282772, encodeId=3893282e72ee, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Jan 28 07:05:21 CST 2018, time=2018-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280581, encodeId=34c628058152, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sun Jan 21 08:28:35 CST 2018, time=2018-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280103, encodeId=584c280103ed, content=好好好好学习天天向上, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQpl0ENSJScphsFtdgfibXX1g1IuEYGCjP23UqCd52TxTpSZibtPiclyusaHicnNXd78alaia19Qy1nAFo18/0, createdBy=50381491660, createdName=zwjnj2, createdTime=Fri Jan 19 18:31:07 CST 2018, time=2018-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279266, encodeId=d67d2e9266a1, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Wed Jan 17 06:38:23 CST 2018, time=2018-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=279202, encodeId=225b2e9202fd, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJpBl6xwMmnsKibwxcAIltOH3nnCEQbNE6TDbYtCKe8hYI0oJrbduNqnJraM1PyyjPKU1suAzicYPaA/132, createdBy=eeaf2031798, createdName=海之蓝, createdTime=Tue Jan 16 21:39:43 CST 2018, time=2018-01-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278458, encodeId=0db72e84580b, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Jan 14 13:56:07 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278342, encodeId=59082e83426f, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sun Jan 14 08:17:54 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278289, encodeId=88e72e828969, content=学习了.谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sun Jan 14 06:11:16 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=278195, encodeId=b3cf2e8195bc, content=了解了解.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sat Jan 13 20:43:52 CST 2018, time=2018-01-13, status=1, ipAttribution=)]
    2018-01-14 1e145228m78(暂无匿称)

    学习了.谢谢作者分享!

    0

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    2018-01-13 1dd8c52fm63(暂无匿称)

    了解了解.继续关注

    0

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2017年12月9日Lancet研究精选——高血压在中国

盘点:2017年12月16日Lancet研究精选

2017年12月16日Lancet研究精选

年终盘点:2017年Lancet杂志十大重磅级突破性研究成果

时光总是匆匆易逝,2017年也已经接近尾声,迎接我们的将是崭新的2018年。本文中小编就盘点了2017年Lancet杂志发表的一些非常有意义的重磅级亮点研究,与各位一起学习! 1、曲妥珠单抗对HER2阳性早期乳腺癌的保护作用可维持11年 DOI: http://dx.doi.org/10.1016/S0140-6736(16)32616-2 曲妥珠单抗是HE

Lancet:颈动脉支架治疗顽固性高血压

在经过治疗的高血压患者汇总,大约10%为顽固性高血压,定义为尽管经过三种或更多种药物治疗(包括利尿剂)患者的血压仍然未被控制。继续增加药物是有效的,但是并不是所有患者都能够长期耐受这些药物。

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