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Dig Liver Dis: 活检证实非酒精性脂肪性肝病患者维生素D水平与维生素D相关基因多态性与肝纤维化有关

2019-07-07 不详 MedSci原创

维生素D具有良好的抗增殖和抗纤维化特性,但其在非酒精性脂肪性肝病(NAFLD)中的临床应用尚不清楚。本研究旨在阐明维生素D水平,维生素D相关基因的单核苷酸多态性(SNPs)与活检证实的NAFLD患者的疾病组织病理学严重程度之间的关系。

背景
维生素D具有良好的抗增殖和抗纤维化特性,但其在非酒精性脂肪性肝病(NAFLD)中的临床应用尚不清楚。本研究旨在阐明维生素D水平,维生素D相关基因的单核苷酸多态性(SNPs)与活检证实的NAFLD患者的疾病组织病理学严重程度之间的关系。

方法
研究人员测定了经活检证实的NAFLD的229名连续患者的CYP2R1,DHCR7,维生素D结合蛋白(GC),CYP27B1和维生素D受体(VDR)中的SNP的血清水平,并将其结果与NAFLD之间的关系进行比较。

结果
在这项研究中,25-羟基维生素D3水平≤20ng/mL被定义为维生素D缺乏。 151名患者(65.9%)发现维生素D缺乏。多变量分析显示,寒冷季节,晚期纤维化和CYP2R1 rs1993116基因型是与维生素D缺乏显着相关的独立因素。高龄(p<0.001),体重指数高(p<0.001),总胆固醇低(p<0.001),血清维生素D水平低(p<0.001)和VDR rs1544410基因型CC(p<0.001)是晚期肝纤维化的独立危险因素。

结论
经活检证实的NAFLD患者血清25-羟维生素D 3水平和VDR基因SNP与肝纤维化的严重程度独立相关。

原始出处:

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    2019-12-13 qjddjq
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  5. 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  6. 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  7. 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    2019-07-09 xzw120

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酒精性脂肪肝与非酒精性脂肪肝对于肝脏相关死亡率的影响目前还没有定论,因此,本项研究旨在探究非酒精性脂肪肝(NAFLD)和酒精性脂肪肝(AFLD)的纤维化严重程度与肝脏相关的死亡之间的关系。

Clin Trans Gastroenterology: 血清可溶性受体AGE(sRAGE)水平与不健康的生活方式和非酒精性脂肪性肝病相关

非酒精性脂肪性肝病(NAFLD)已被证实与血清糖基化终产物(AGEs)呈正相关关系,而在一些小型研究中与AGE可溶性受体(sRAGE)呈负相关。因此,本项研究的目的是评估生活方式和sRAGE水平之间的关联以及sRAGE水平或AGEs摄入量与NAFLD,胰岛素抵抗(IR)和升高的丙氨酸氨基转移酶(ALT)之间的关联。

AJG:年轻男性的性激素结合球蛋白水平与中年非酒精性脂肪肝相关

有研究数据显示,患有非酒精性脂肪性肝病(NAFLD)的男性睾酮和性激素结合球蛋白(SHBG)水平较低。目前尚不清楚年轻男性的性激素水平是否可预测NAFLD的预后结局,因此,本项研究旨在探究这二者之间的关系。

Dig Liver Dis: 膳食中维生素E和C能减缓非酒精性脂肪性肝病的病情

尽管抗氧化剂在非酒精性脂肪性肝病(NAFLD)和脂肪性肝炎(NASH)中具有保护作用,但关于膳食摄入抗氧化剂的作用的证据有限。本项研究的目的是探究膳食维生素E和C摄入量与NAFLD,NASH和纤维化标志物之间的关系。

Gastroenterology:非酒精性脂肪性肝病与肠道微生物群变化

本文验证了非酒精性脂肪性肝病与肠道微生物群变化的相关性,肠道微生物群的改变可作为疾病或严重程度的标志物

J Gastroenterology:非酒精性脂肪肝的发生与儿童人群中较低的乙型肝炎病毒载量和抗病毒反应相关

目前为止人们对于非酒精性脂肪性肝病(NAFLD)与慢性乙型肝炎感染(CBI)之间的相互作用尚不清楚。本项研究旨在探究NAFLD与CBI之间的关联以及NAFLD对儿童人群抗病毒治疗反应的影响。

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