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Int Forum Allergy Rhinol:在美国,慢性鼻窦炎症是鼻咽癌和鼻窦恶性肿瘤的预兆因子

2017-06-21 AlexYang MedSci原创

有研究表明,慢性炎症状态与恶性肿瘤的发展相关。在亚洲一个基于群体的研究中,慢性鼻窦炎(CRS)和过敏性鼻炎(AR)与鼻咽癌(NPC)相关。但是,一个相似的NPC和副鼻窦恶性肿瘤(PSM)与炎症的关系在北美人口中并没有被研究。最近,有研究人员调查了CRS和AR对NPC和PSM风险的影响。研究人员将监督、流行病学和最终结果(SEER)医疗保险相关数据库作为年龄不小于65岁成人的案例-对照研究查询对象。

有研究表明,慢性炎症状态与恶性肿瘤的发展相关。在亚洲一个基于群体的研究中,慢性鼻窦炎(CRS)和过敏性鼻炎(AR)与鼻咽癌(NPC)相关。但是,一个相似的NPC和副鼻窦恶性肿瘤(PSM)与炎症的关系在北美人口中并没有被研究。最近,有研究人员调查了CRS和AR对NPC和PSM风险的影响。研究人员将监督、流行病学和最终结果(SEER)医疗保险相关数据库作为年龄不小于65岁成人的案例-对照研究查询对象。研究总共包括了在2003年和2011年的2009名诊断为NPC和/或者PSM的病人,并且还包括了从医疗保险受益人5%的随机样本中选择的2009名无癌症倾向分值匹配法对照群体。CRS和AR通过曝光进行检查,研究还利用了多变量非条件逻辑回归进行分析。

研究发现,NPC和PSM病人比对照先前更有可能具有CRS诊断结果(分别为:9.2% vs 3.0% and 11.1% vs 2.7%)。CRS同样与发展为NPC(odds ratio [OR], 3.51; 95% confidence interval [CI], 2.12-5.79)和PSM(OR, 5.30; 95% CI, 3.55-7.92)更大的几率相关。AR与发展为NPC(OR, 4.23; 95% CI, 2.96 to 6.06)和PSM(OR, 3.35; 95% CI, 2.49-4.49)更大的几率相关。总之,研究人员指出,CRS和AR在美国老龄人口中的NPC和PSM有关。另外,该流行病学联系需要进行病因病理机制检查和临床诊断效用检验。

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    2017-06-23 膀胱癌
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    2017-06-22 Y—xianghai

    学习了新知识

    0

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    2017-06-22 半夏微凉

    学习了谢谢分享

    0

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    2017-06-21 林3301

    在中国,好多慢性鼻窦炎

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