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Ann Surg:食管或胃食管交界处腺癌患者的不同淋巴结转移位置的不同影响

2016-12-19 小丑鱼儿 Ann Surg:食管或胃食管交界处腺癌

研究对象为食管或胃食管交界处(GEJ)腺癌患者,新辅助治疗后食管切除术治疗腺癌,研究目的是确定淋巴结转移位置的预后意义。

研究对象为食管或胃食管交界处(GEJ)腺癌患者,新辅助治疗后食管切除术治疗腺癌,研究目的是确定淋巴结转移位置的预后意义。新辅助治疗后检测上纵隔及腹腔动脉的淋巴结转移,切除不改变食管肿瘤的TNM分类。这些远处的淋巴结转移对生存的影响仍不清楚。 2003年3月到2013年9月,纳入479例远端食管或GEJ腺癌患者,新辅助治疗后,进行整块2场淋巴结清扫术,根据切除标本的淋巴结阳性定位,分析生存率。253例患者的切除标本有淋巴结转移。这些患者中,92例患者其局部节点已经转移,114例腹腔干转移,21例胸部近端转移,26例腹腔干和局部均有转移。没有淋巴结转移的患者其中位无病生存期为170个月,局部转移者为35个月,腹腔干转移者为16个月,胸部近端转移者为15个月,腹腔干和局部均有转移者为8个月。多因素分析中,淋巴结转移的位置与生存独立相关。淋巴结转移灶的定位是生存的独立预测因子。沿腹腔轴和/或近端区域的相对遥远的淋巴结转移对生存有负面影响。因此,未来食管和GEJ腺癌分期系统应该考虑淋巴结转移位置。原始出处:Anderegg MC1, Lagarde SM, Jagadesham VP,

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    2016-12-21 sodoo
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    2016-12-21 zhouqu_8

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