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Gastric Cancer: 糖尿病与胃癌的风险增加有关

2020-07-18 MedSci原创 MedSci原创

糖尿病(DM)被认为是胃癌的潜在危险因素,本项研究旨在通过内窥镜评估评估人群中DM与胃癌的相关性。

背景

糖尿病(DM)被认为是胃癌的潜在危险因素,本项研究旨在通过内窥镜评估评估人群中DM与胃癌的相关性。

 

方法

研究人员对2003年至2014年在基线和随访期间接受内镜检查的195312名成年男性和女性进行了一项回顾性队列研究。DM被定义为空腹血糖≥126 mg / dL,自我报告的DM病史或当前使用情况抗糖尿病药物。胃癌的证实则通过组织学进行。

 

结果

基线时DM的患病率为3.0%(n  = 5774),随访结束时有198名参与者患了胃癌。与基线时有和没有DM的参与者相比,发生胃癌的完全调整的危险比(HR)为1.76 [95%置信区间(CI)1.04–2.97;P  = 0.033)。当我们将DM评估为随时间变化的协变量时,完全调整的HR为1.66(95%CI 1.04–2.68;P  = 0.036)。DM与胃癌的相关性因肠上皮化生而无差异(P = 0.61)。

 

结论

DM与胃癌的发生率增加独立相关。风险增加与粘膜萎缩和肠上皮化生无关,并且在随访期间与新近发展的DM参与者保持一致。DM患者可能需要更深入的内镜随访以筛查胃癌的发生。

 

原始出处:

Hyo-Joon Yang. Et al. Diabetes mellitus is associated with an increased risk of gastric cancer: a cohort study. Gastric Cancer. 2020.

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    2020-08-16 许安
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    2020-07-29 skhzy
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    2020-07-17 misszhang

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