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Sci Rep:MRPS18-2蛋白水平与前列腺肿瘤恶化相关且可诱导CXCR4依赖的癌症细胞迁移

2018-02-08 AlexYang MedSci原创

之前,有研究人员发现了在子宫内膜癌中,与良性增生和正常子宫内膜相比较,线粒体核糖蛋白S18-2(MRPS18-2, S18-2)的异常表达。最近,有研究人员报道了在前列腺癌(PCa)临床活检中,S18-2的表达水平会随着疾病的恶化表达水平增加。上皮细胞向间充质细胞转化(EMT)的诱导水平与S18-2在PCa细胞系中的表达水平相关。更多的是,细胞依赖S18-2的过表达,细胞获得了更强的迁移能力,且与

之前,有研究人员发现了在子宫内膜癌中,与良性增生和正常子宫内膜相比较,线粒体核糖蛋白S18-2(MRPS18-2, S18-2)的异常表达。

最近,有研究人员报道了在前列腺癌(PCa)临床活检中,S18-2的表达水平会随着疾病的恶化表达水平增加。上皮细胞向间充质细胞转化(EMT)的诱导水平与S18-2在PCa细胞系中的表达水平相关。更多的是,细胞依赖S18-2的过表达,细胞获得了更强的迁移能力,且与在斑马鱼胚胎模型和trans-well试验中的评估结果相似。另外,研究人员还发现,上述现象的出现归因于CXCR4细胞表面表达的增加。中和CXCR4蛋白或者抑制S18-2的表达能够显著的减少它们的迁移能力。TWIST2能够编码一个依赖CXCR4增加而诱导EMT的一个转录因子,它的mRNA的表达与S18-2蛋白水平呈正相关关系。

最后,研究人员指出,这些数据表明了S18-2蛋白可以通过WTIST2/E-钙粘蛋白信号来诱导EMT,最终影响CXCR4调控的前列腺癌细胞的迁移。

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    2018-12-21 hb2008ye
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    2018-04-18 zhwj
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本研究旨在验证计算机辅助诊断(CAD)系统通过多参数MR成像对前列腺外周带(PZ)肿瘤的影像学特征来进行诊断的价值,并将结果发表在Radiology上。

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