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JAHA:既往与新发房颤与急性肺栓塞患者结局之间的关系

2021-08-29 MedSci原创 MedSci原创

在急性症状性PE患者中,既往AF和新发AF均可预测不良的临床结局。不良结局的类型可能因AF发生的时机而异。

心房颤动(AF)可能在肺栓塞(PE)之前或早期发生。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员旨在根据AF的存在和发生时机确定PE患者结局。


研究人员使用了来自多中心PE登记中心的数据,确定了3个组别:(1)先前伴有AF的患者,(2)急性PE后2天内新发AF(突发性AF)患者,以及(3)无AF的患者。研究人员评估了AF患者与没有AF的患者(参考组)相比,90天和1年的死亡和卒中风险。

在16497名PE患者中,792名预先伴有AF。与没有AF的患者相比,这些患者的90天全因(比值比[OR]为2.81;95%CI为2.33-3.38)和PE相关死亡率(OR为2.38;95%CI为1.37-4.14)增加,1年的缺血性卒中风险增加(风险比为5.48;95%CI为3.10-9.69)。多变量调整后,既往AF与全因死亡率(OR为1.91;95%CI为1.57–2.32)显着增加相关,但与PE相关死亡率(OR为1.50;95%CI为0.85–2.66)无关。在16497名PE患者中,445名在急性PE后2天内发生了新的AF。AF与90天全因死亡率(OR为2.28;95%CI为1.75-2.97)和PE相关死亡率(OR为3.64;95%CI为2.01-6.59)增加相关,但与卒中无关。多变量分析的结果相似。
 
在急性症状性PE患者中,既往AF和新发AF均可预测不良的临床结局。不良结局的类型可能因AF发生的时机而异。

原始出处:

Behnood Bikdeli.et al.Association Between Preexisting Versus Newly Identified Atrial Fibrillation and Outcomes of Patients With Acute Pulmonary Embolism.JAHA.2021.https://www.ahajournals.org/doi/10.1161/JAHA.121.021467

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    2021-08-31 docwu2019
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    2021-08-30 心介

    房颤,临床上碰到很多哦

    0

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