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Lancet:依维莫司治疗晚期无功能性肺或胃肠道神经内分泌肿瘤,安全有效

2015-12-16 崔倩 译 MedSci原创

肺或胃肠道的神经内分泌肿瘤患者的有效全身治疗方法稀少。该研究的目的是评估在这一患者群体中依维莫与安慰剂相比的疗效和安全性。

肺或胃肠道的神经内分泌肿瘤患者的有效全身治疗方法稀少。该研究的目的是评估在这一患者群体依维莫司与安慰剂相比的疗效和安全性。

在该项随机、双盲、安慰剂对照、3期RADIANT-4试验中,晚期的、有进展的、分化良好的、无功能的肺或神经内分泌消化道肿瘤的成年患者(年龄≥18岁)来自于全球25个国家97个中心。符合条件的患者通过互动式语音应答系统被随机以2:1的比例分配接受依维莫司10毫克,每天口服或相同的安慰剂,都有支持治疗。患者通过肿瘤的起源,性能状态和以前的生长抑素类似物治疗进行分层。患者,研究者和研究申办者都不知道治疗分配。主要终点是无进展生存期由中心放射学审查评估,通过意向性治疗分析。总生存期是一个关键的次要终点。

在2012年4月3日和2013年8月23日之间,共有302名患者参加此次研究,其中205例被分配每天接受依维莫司10毫克,97例接受安慰剂。依维莫司组的中位无进展生存期为11.0个月(95%Cl为9.2-13.3),安慰剂组为3.9个月(3.6-7.4)。依维莫司降低了进展或死亡的估计风险的52%(危险比(HR)0.48 [95%Cl 0.35-0.67,P<0.00001)。尽管没有统计学意义,第一预计划的中期总体生存分析的结果表明,依维莫司可能会减少死亡的风险(HR 0.64[95%Cl 0.40-1.05],单边P=0.037,而对于统计显着性的边界是0.0002)。3或4级药物相关的不良事件比较少见,包括口炎(依维莫司组中202例患者中的18例[9%] vs 安慰剂组98例患者中的0例)、腹泻(15[7%] vs 2[2% ])、感染(14 [7%] vs 0)、贫血(8[4%] vs 1[1%])、疲劳(7[3%] vs 1[1%)]和高血糖(7[3 %] vs 0)。

用依维莫司治疗,可显著改善晚期无功能性肺或胃肠道神经内分泌肿瘤患者的无进展生存期。安全性结果与依维莫司的已知副作用情况是一致的。依维莫司是第一个靶向剂,有可接受的耐受性,对广泛范围内的神经内分泌肿瘤有抗肿瘤活性,包括那些来自胰腺、肺和胃肠道所产生的肿瘤。

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    2016-01-11 gwc392
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    2016-09-20 howi
  5. [GetPortalCommentsPageByObjectIdResponse(id=1915399, encodeId=a874191539998, content=<a href='/topic/show?id=22a1328e7e5' target=_blank style='color:#2F92EE;'>#功能性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32877, encryptionId=22a1328e7e5, topicName=功能性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=570f404, createdName=xlxchina, createdTime=Wed Jan 20 14:44:00 CST 2016, time=2016-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682226, encodeId=b2711682226d7, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Mon Jan 11 19:44:00 CST 2016, time=2016-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1953690, encodeId=3b9f1953690cd, content=<a href='/topic/show?id=9bdbe41946e' target=_blank style='color:#2F92EE;'>#神经内分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74194, encryptionId=9bdbe41946e, topicName=神经内分泌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8143398, createdName=lily1616, createdTime=Fri Oct 07 02:44:00 CST 2016, time=2016-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1828353, encodeId=9fde182835330, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Tue Sep 20 02:44:00 CST 2016, time=2016-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2027297, encodeId=cec3202e297bc, content=<a href='/topic/show?id=d80a589182c' target=_blank style='color:#2F92EE;'>#无功能性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58918, encryptionId=d80a589182c, topicName=无功能性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Tue Aug 16 07:44:00 CST 2016, time=2016-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1763460, encodeId=14401e634601f, content=<a href='/topic/show?id=3fc83035361' target=_blank style='color:#2F92EE;'>#内分泌肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30353, encryptionId=3fc83035361, topicName=内分泌肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=763a37536718, createdName=1249898am27暂无昵称, createdTime=Sat Jan 23 10:44:00 CST 2016, time=2016-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48315, encodeId=60a34831511, content=好文章,值得看。, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 16:25:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1346199, encodeId=96f5134619919, content=<a href='/topic/show?id=339e8332035' target=_blank style='color:#2F92EE;'>#胃肠道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83320, encryptionId=339e8332035, topicName=胃肠道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Fri Dec 18 06:44:00 CST 2015, time=2015-12-18, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1915399, encodeId=a874191539998, content=<a href='/topic/show?id=22a1328e7e5' target=_blank style='color:#2F92EE;'>#功能性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32877, encryptionId=22a1328e7e5, topicName=功能性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=570f404, createdName=xlxchina, createdTime=Wed Jan 20 14:44:00 CST 2016, time=2016-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682226, encodeId=b2711682226d7, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Mon Jan 11 19:44:00 CST 2016, time=2016-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1953690, encodeId=3b9f1953690cd, content=<a href='/topic/show?id=9bdbe41946e' target=_blank style='color:#2F92EE;'>#神经内分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74194, encryptionId=9bdbe41946e, topicName=神经内分泌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8143398, createdName=lily1616, createdTime=Fri Oct 07 02:44:00 CST 2016, time=2016-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1828353, encodeId=9fde182835330, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Tue Sep 20 02:44:00 CST 2016, time=2016-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2027297, encodeId=cec3202e297bc, content=<a href='/topic/show?id=d80a589182c' target=_blank style='color:#2F92EE;'>#无功能性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58918, encryptionId=d80a589182c, topicName=无功能性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Tue Aug 16 07:44:00 CST 2016, time=2016-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1763460, encodeId=14401e634601f, content=<a href='/topic/show?id=3fc83035361' target=_blank style='color:#2F92EE;'>#内分泌肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30353, encryptionId=3fc83035361, topicName=内分泌肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=763a37536718, createdName=1249898am27暂无昵称, createdTime=Sat Jan 23 10:44:00 CST 2016, time=2016-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48315, encodeId=60a34831511, content=好文章,值得看。, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 16:25:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1346199, encodeId=96f5134619919, content=<a href='/topic/show?id=339e8332035' target=_blank style='color:#2F92EE;'>#胃肠道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83320, encryptionId=339e8332035, topicName=胃肠道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Fri Dec 18 06:44:00 CST 2015, time=2015-12-18, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1915399, encodeId=a874191539998, content=<a href='/topic/show?id=22a1328e7e5' target=_blank style='color:#2F92EE;'>#功能性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32877, encryptionId=22a1328e7e5, topicName=功能性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=570f404, createdName=xlxchina, createdTime=Wed Jan 20 14:44:00 CST 2016, time=2016-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682226, encodeId=b2711682226d7, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Mon Jan 11 19:44:00 CST 2016, time=2016-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1953690, encodeId=3b9f1953690cd, content=<a href='/topic/show?id=9bdbe41946e' target=_blank style='color:#2F92EE;'>#神经内分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74194, encryptionId=9bdbe41946e, topicName=神经内分泌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8143398, createdName=lily1616, createdTime=Fri Oct 07 02:44:00 CST 2016, time=2016-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1828353, encodeId=9fde182835330, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Tue Sep 20 02:44:00 CST 2016, time=2016-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2027297, encodeId=cec3202e297bc, content=<a href='/topic/show?id=d80a589182c' target=_blank style='color:#2F92EE;'>#无功能性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58918, encryptionId=d80a589182c, topicName=无功能性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Tue Aug 16 07:44:00 CST 2016, time=2016-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1763460, encodeId=14401e634601f, content=<a href='/topic/show?id=3fc83035361' target=_blank style='color:#2F92EE;'>#内分泌肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30353, encryptionId=3fc83035361, topicName=内分泌肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=763a37536718, createdName=1249898am27暂无昵称, createdTime=Sat Jan 23 10:44:00 CST 2016, time=2016-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48315, encodeId=60a34831511, content=好文章,值得看。, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 16:25:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1346199, encodeId=96f5134619919, content=<a href='/topic/show?id=339e8332035' target=_blank style='color:#2F92EE;'>#胃肠道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83320, encryptionId=339e8332035, topicName=胃肠道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Fri Dec 18 06:44:00 CST 2015, time=2015-12-18, status=1, ipAttribution=)]
    2015-12-26 hixiaoluo

    好文章,值得看。

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1915399, encodeId=a874191539998, content=<a href='/topic/show?id=22a1328e7e5' target=_blank style='color:#2F92EE;'>#功能性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32877, encryptionId=22a1328e7e5, topicName=功能性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=570f404, createdName=xlxchina, createdTime=Wed Jan 20 14:44:00 CST 2016, time=2016-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682226, encodeId=b2711682226d7, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Mon Jan 11 19:44:00 CST 2016, time=2016-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1953690, encodeId=3b9f1953690cd, content=<a href='/topic/show?id=9bdbe41946e' target=_blank style='color:#2F92EE;'>#神经内分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74194, encryptionId=9bdbe41946e, topicName=神经内分泌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8143398, createdName=lily1616, createdTime=Fri Oct 07 02:44:00 CST 2016, time=2016-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1828353, encodeId=9fde182835330, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Tue Sep 20 02:44:00 CST 2016, time=2016-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2027297, encodeId=cec3202e297bc, content=<a href='/topic/show?id=d80a589182c' target=_blank style='color:#2F92EE;'>#无功能性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58918, encryptionId=d80a589182c, topicName=无功能性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, createdName=snf701207, createdTime=Tue Aug 16 07:44:00 CST 2016, time=2016-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1763460, encodeId=14401e634601f, content=<a href='/topic/show?id=3fc83035361' target=_blank style='color:#2F92EE;'>#内分泌肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30353, encryptionId=3fc83035361, topicName=内分泌肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=763a37536718, createdName=1249898am27暂无昵称, createdTime=Sat Jan 23 10:44:00 CST 2016, time=2016-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=48315, encodeId=60a34831511, content=好文章,值得看。, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 16:25:00 CST 2015, time=2015-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1346199, encodeId=96f5134619919, content=<a href='/topic/show?id=339e8332035' target=_blank style='color:#2F92EE;'>#胃肠道#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83320, encryptionId=339e8332035, topicName=胃肠道)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Fri Dec 18 06:44:00 CST 2015, time=2015-12-18, status=1, ipAttribution=)]

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目的: 并不是所有自身免疫性肝炎(AIH) 患者对皮质类固醇和硫唑嘌呤的标准药物治疗都有反应。这类患者可能由于其较差的预后会发展为末期肝病,除非采取移植。另外,新的治疗策略的引入可能潜在的改善肝功能的恶化。在我们高等教育中心的病人,当对标准的和有经验的药物组合的使用呈现无反应或不耐受 (如霉酚酸酯,钙调磷酸酶抑制剂(CNIs))时,给予依维莫司的治疗。我们在这里报告依维莫司治疗自身免疫性肝炎的疗效

NEJM:对糖尿病患者行冠脉洗脱支架,依维莫司优于紫杉醇

药物洗脱支架的选择目前仍存在争议。先前有研究比较了紫杉醇洗脱支架和雷帕霉素(或与其类似药物如依维莫司、唑他莫司)洗脱支架,但得出了矛盾的结果。

IKCS 14th:转移性肾细胞癌三线治疗的有效性

有研究表明对转移性肾细胞癌 (mRCC)使用三线治疗,疗效尚可。不过该有效性并没有得到很透彻的研究。Stukalin和他的同事进行了一项研究,评估上限治疗方案对mRCC患者的有效性。该研究纳入了 4824名使用过一线治疗方案的患者,其中2534 (52.5%) 的患者接受二线治疗,1060 (22%)的患者接受三线治疗。研究者发现三线治疗里最常用的药物是依维莫司,而该药物也是二线治疗最常用的药物。

NEJM:卡博替尼治疗晚期肾癌效果更佳

卡博替尼是一种口服的小分子酪氨酸激酶抑制剂,能够靶向癌细胞的逃逸机制相关的蛋白如酪氨酸激酶MET和AXL。研究者进行了一项3期试验,比较卡博替尼和依维莫司对经VEGFR靶向治疗后的晚期肾癌患者的疗效。该研究共纳入658名患者,随机分为卡博替尼组(60mg/d)和依维莫司组(10mg/d)。初始结局指标为无进展生存期;继发结局指标为整体生存率和反应率。研究数据显示,卡博替尼组的无进展生存期中位数7.

NEJM:冠状动脉疾病的依维莫司洗脱支架或搭桥手术试验

背景 大多数比较经皮冠状动脉介入治疗(PCI)和冠状动脉旁路移植术(CABG)的试验没有使用第二代药物洗脱支架。 方法 我们在东亚27个中心进行了一项随机性试验。我们计划随机分配1776例冠状动脉多支病变患者进行依维莫司洗脱支架的经皮冠动脉介入治疗或冠状动脉搭桥术。在随机治疗的2年后主要终点是死亡,心肌梗死,或靶血管血运重建。在长期随访也比较了组间的事件发生率。 结果 880例报名后(438例

Lancet Oncol:Lenvatinib加依维莫司和lenvatinib单药治疗转移性肾细胞癌效果好

目前,转移性肾细胞癌通常使用靶向VEGF或mTOR的单一药物治疗。该研究的目的是评估lenvatinib,依维莫司,或它们的组合作为二线治疗转移性肾细胞癌患者的效果。研究人员在五个国家37个中心做了一项随机,2期,开放性,多中心的试验,参与的患者患有晚期或转移性,透明细胞,肾细胞癌。该研究包括那些接受VEGF靶向治疗,并有病情进展或在停药9个月内的患者。患者经由交互式语音应答系统按照1:1的比例接

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