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Diabetologia:系统性产热代谢物琥珀酸和12,13二聚体与肥胖和相关的代谢特征呈负相关:来自大型人类横断面研究的证据

2019-12-24 MedSci MedSci原创

最近研究表明,循环琥珀酸和12,13-二羟基- 9z -十八烯酸(12,13-二羟基- 9z -十八烯酸)能促进棕色脂肪细胞产热,并能预防啮齿动物的代谢紊乱。本研究旨在评估这些代谢物的血浆水平与人类肥胖和代谢状况之间的关系。

最近研究表明,循环琥珀酸和12,13-二羟基- 9z -十八烯酸(12,13-二羟基- 9z -十八烯酸)能促进棕色脂肪细胞产热,并能预防啮齿动物的代谢紊乱。本研究旨在评估这些代谢物的血浆水平与人类肥胖和代谢状况之间的关系。

研究人员使用超高效液相色谱串联质谱(ultra HPLC-tandem MS)2248名个体(50%女性,平均年龄41.3±5.9岁,平均BMI 26.1±4.6 kg/m2)空腹血浆生化指标外及空腹血浆琥珀酸盐和12,13- dihome水平进行了量化。用双能x线骨密度仪测定全身和局部脂肪含量。用年龄和性别校正的线性回归模型来确定琥珀酸和12,13-二聚体水平与身体组成和代谢水平之间的关系。采用双样本孟德尔随机化法评估循环血浆琥珀酸盐和12,13- dihome与遗传决定的BMI和代谢特征之间的关系。

血浆琥珀酸酯浓度高一SD12,13-diHOME浓度分别与总脂肪量降低0.15 SD95CI 0.280.03)和0.08 SD0.150.01)有关。 此外,血浆12,13-diHOME水平升高一个SD与空腹血浆胰岛素降低0.09 SD0.160.02)和血浆三酰甘油降低0.10 SD0.170.04)相关。 在孟德尔随机分析中,遗传确定的较高的BMI,空腹高胰岛素血症和血脂水平升高与血浆琥珀酸或血浆12,13-diHOME浓度的变化无关。在孟德尔随机化分析中没有发现由于方向多效性而导致的偏倚迹象。

本研究的发现初步表明,血浆琥珀酸盐和12,13- dihome可能在调节人体能量代谢和棕色脂肪组织激活方面发挥作用。进一步的研究包括直接评估棕色脂肪组织活动和饮食补充,以调查这些代谢物对全身代谢的潜在有益影响。

原始出处:

Senthil K. VasanRaymond NoordamThe proposed systemic thermogenic metabolites succinate and 12,13-diHOME are inversely associated with adiposity and related metabolic traits: evidence from a large human cross-sectional study

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    2020-04-27 heli0118
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    2020-06-07 hxj0117
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    2019-12-26 hmwwww

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