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Br J Cancer:即使体重正常,体脂指标也与癌症发病风险相关

2021-03-23 xiaozeng MedSci原创

肥胖被认为是至少13种不同类型癌症的危险因素之一。

肥胖被认为是至少13种不同类型癌症的危险因素之一。为了确定人体脂肪水平,大多数流行病学研究均采用身体质量指数(BMI,以体重(kg)/身高(m2)计算)。然而,目前并不清楚体重正常的人(BMI:18.5–24.9 kg/m2)的体脂成分与癌症发病风险之间的关联性。

在该研究中,研究人员通过分析在2006年至2010年期间纳入英国生物样本库(UK Biobank)队列的149,928名体重正常(40-70岁)的个体,研究肥胖与乳腺癌(绝经后)、子宫内膜癌、卵巢癌结直肠癌发生风险的相关性。

结果显示,所有体脂指标均与绝经后浸润性乳腺癌发病风险呈正相关。而躯干脂肪质量指数和腰围(WC)与子宫内膜癌的发病风险呈正相关。在男性中,躯干:大腿的去脂质量比、躯干:大腿的脂肪质量比与结肠癌的发病风险呈正相关。而女性的体脂指标与卵巢癌或结直肠癌的发病风险无关。

英国生物样本库参与者相关特征

综上,该研究结果表明,基于BMI的正常体重人群中的相关脂肪成分数据表现出与肥胖相关癌症的发病风险增加的相关性。


原始出处:

Arthur, R.S., Dannenberg, A.J., Kim, M. et al. The association of body fat composition with risk of breast, endometrial, ovarian and colorectal cancers among normal weight participants in the UK Biobank. Br J Cancer (15 March 2021).

 



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  1. [GetPortalCommentsPageByObjectIdResponse(id=961874, encodeId=6a889618e42b, content=<a href='/topic/show?id=d12d1042620a' target=_blank style='color:#2F92EE;'>#Br J Cancer#</a>点击查看更多相关话题,或评论点击插入您喜欢的话题, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104262, encryptionId=d12d1042620a, topicName=Br J Cancer)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20221103/2796e00c9b4549e3b313ed9e7accc68f/b52d6d98bbe04782b5a4e2dd1ee80be2.jpeg, createdBy=078e1614372, createdName=MedSciZeng, createdTime=Fri Apr 30 17:22:56 CST 2021, time=2021-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544093, encodeId=ee0e1544093f5, content=<a href='/topic/show?id=610d266582b' target=_blank style='color:#2F92EE;'>#体脂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26658, encryptionId=610d266582b, topicName=体脂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Wed Mar 24 15:55:08 CST 2021, time=2021-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=950621, encodeId=89cd950621ff, content=很棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3be85451515, createdName=ms3000001264084725, createdTime=Wed Mar 24 08:41:57 CST 2021, time=2021-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=950251, encodeId=b7ef950251c1, content=很有收获, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/1ReyQDb42vOics2FHYXlVv4onqAVCCoGgJFtRPfHHGMebZrZGHh77B1VVEahia8nPiaTaTq4icGxibJ7wLetml5FCBg/132, createdBy=9d3c2202243, createdName=Jo不是个男名, createdTime=Tue Mar 23 08:12:18 CST 2021, time=2021-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=950249, encodeId=6496950249f0, content=肥胖缺点多多, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b7a31928393, createdName=学医无涯, createdTime=Tue Mar 23 08:05:14 CST 2021, time=2021-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=950238, encodeId=44119502386e, content=所以每天跑步相当重要,锻炼身体才有革命的本钱啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9c6d5397190, createdName=ms8000001722700191, createdTime=Tue Mar 23 04:55:02 CST 2021, time=2021-03-23, status=1, ipAttribution=)]
    2021-04-30 MedSciZeng

    #Br J Cancer#点击查看更多相关话题,或评论点击插入您喜欢的话题

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=961874, encodeId=6a889618e42b, content=<a href='/topic/show?id=d12d1042620a' target=_blank style='color:#2F92EE;'>#Br J Cancer#</a>点击查看更多相关话题,或评论点击插入您喜欢的话题, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104262, encryptionId=d12d1042620a, topicName=Br J Cancer)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20221103/2796e00c9b4549e3b313ed9e7accc68f/b52d6d98bbe04782b5a4e2dd1ee80be2.jpeg, createdBy=078e1614372, createdName=MedSciZeng, createdTime=Fri Apr 30 17:22:56 CST 2021, time=2021-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544093, encodeId=ee0e1544093f5, content=<a href='/topic/show?id=610d266582b' target=_blank style='color:#2F92EE;'>#体脂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26658, encryptionId=610d266582b, topicName=体脂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Wed Mar 24 15:55:08 CST 2021, time=2021-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=950621, encodeId=89cd950621ff, content=很棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3be85451515, createdName=ms3000001264084725, createdTime=Wed Mar 24 08:41:57 CST 2021, time=2021-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=950251, encodeId=b7ef950251c1, content=很有收获, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/1ReyQDb42vOics2FHYXlVv4onqAVCCoGgJFtRPfHHGMebZrZGHh77B1VVEahia8nPiaTaTq4icGxibJ7wLetml5FCBg/132, createdBy=9d3c2202243, createdName=Jo不是个男名, createdTime=Tue Mar 23 08:12:18 CST 2021, time=2021-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=950249, encodeId=6496950249f0, content=肥胖缺点多多, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b7a31928393, createdName=学医无涯, createdTime=Tue Mar 23 08:05:14 CST 2021, time=2021-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=950238, encodeId=44119502386e, content=所以每天跑步相当重要,锻炼身体才有革命的本钱啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9c6d5397190, createdName=ms8000001722700191, createdTime=Tue Mar 23 04:55:02 CST 2021, time=2021-03-23, status=1, ipAttribution=)]
    2021-03-24 hb2008ye
  3. [GetPortalCommentsPageByObjectIdResponse(id=961874, encodeId=6a889618e42b, content=<a href='/topic/show?id=d12d1042620a' target=_blank style='color:#2F92EE;'>#Br J Cancer#</a>点击查看更多相关话题,或评论点击插入您喜欢的话题, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104262, encryptionId=d12d1042620a, topicName=Br J Cancer)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20221103/2796e00c9b4549e3b313ed9e7accc68f/b52d6d98bbe04782b5a4e2dd1ee80be2.jpeg, createdBy=078e1614372, createdName=MedSciZeng, createdTime=Fri Apr 30 17:22:56 CST 2021, time=2021-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544093, encodeId=ee0e1544093f5, content=<a href='/topic/show?id=610d266582b' target=_blank style='color:#2F92EE;'>#体脂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26658, encryptionId=610d266582b, topicName=体脂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Wed Mar 24 15:55:08 CST 2021, time=2021-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=950621, encodeId=89cd950621ff, content=很棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3be85451515, createdName=ms3000001264084725, createdTime=Wed Mar 24 08:41:57 CST 2021, time=2021-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=950251, encodeId=b7ef950251c1, content=很有收获, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/1ReyQDb42vOics2FHYXlVv4onqAVCCoGgJFtRPfHHGMebZrZGHh77B1VVEahia8nPiaTaTq4icGxibJ7wLetml5FCBg/132, createdBy=9d3c2202243, createdName=Jo不是个男名, createdTime=Tue Mar 23 08:12:18 CST 2021, time=2021-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=950249, encodeId=6496950249f0, content=肥胖缺点多多, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b7a31928393, createdName=学医无涯, createdTime=Tue Mar 23 08:05:14 CST 2021, time=2021-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=950238, encodeId=44119502386e, content=所以每天跑步相当重要,锻炼身体才有革命的本钱啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9c6d5397190, createdName=ms8000001722700191, createdTime=Tue Mar 23 04:55:02 CST 2021, time=2021-03-23, status=1, ipAttribution=)]
    2021-03-24 ms3000001264084725

    很棒

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=961874, encodeId=6a889618e42b, content=<a href='/topic/show?id=d12d1042620a' target=_blank style='color:#2F92EE;'>#Br J Cancer#</a>点击查看更多相关话题,或评论点击插入您喜欢的话题, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104262, encryptionId=d12d1042620a, topicName=Br J Cancer)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20221103/2796e00c9b4549e3b313ed9e7accc68f/b52d6d98bbe04782b5a4e2dd1ee80be2.jpeg, createdBy=078e1614372, createdName=MedSciZeng, createdTime=Fri Apr 30 17:22:56 CST 2021, time=2021-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544093, encodeId=ee0e1544093f5, content=<a href='/topic/show?id=610d266582b' target=_blank style='color:#2F92EE;'>#体脂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26658, encryptionId=610d266582b, topicName=体脂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Wed Mar 24 15:55:08 CST 2021, time=2021-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=950621, encodeId=89cd950621ff, content=很棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3be85451515, createdName=ms3000001264084725, createdTime=Wed Mar 24 08:41:57 CST 2021, time=2021-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=950251, encodeId=b7ef950251c1, content=很有收获, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/1ReyQDb42vOics2FHYXlVv4onqAVCCoGgJFtRPfHHGMebZrZGHh77B1VVEahia8nPiaTaTq4icGxibJ7wLetml5FCBg/132, createdBy=9d3c2202243, createdName=Jo不是个男名, createdTime=Tue Mar 23 08:12:18 CST 2021, time=2021-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=950249, encodeId=6496950249f0, content=肥胖缺点多多, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b7a31928393, createdName=学医无涯, createdTime=Tue Mar 23 08:05:14 CST 2021, time=2021-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=950238, encodeId=44119502386e, content=所以每天跑步相当重要,锻炼身体才有革命的本钱啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9c6d5397190, createdName=ms8000001722700191, createdTime=Tue Mar 23 04:55:02 CST 2021, time=2021-03-23, status=1, ipAttribution=)]
    2021-03-23 Jo不是个男名

    很有收获

    0

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    2021-03-23 学医无涯

    肥胖缺点多多

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=961874, encodeId=6a889618e42b, content=<a href='/topic/show?id=d12d1042620a' target=_blank style='color:#2F92EE;'>#Br J Cancer#</a>点击查看更多相关话题,或评论点击插入您喜欢的话题, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=104262, encryptionId=d12d1042620a, topicName=Br J Cancer)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20221103/2796e00c9b4549e3b313ed9e7accc68f/b52d6d98bbe04782b5a4e2dd1ee80be2.jpeg, createdBy=078e1614372, createdName=MedSciZeng, createdTime=Fri Apr 30 17:22:56 CST 2021, time=2021-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1544093, encodeId=ee0e1544093f5, content=<a href='/topic/show?id=610d266582b' target=_blank style='color:#2F92EE;'>#体脂#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26658, encryptionId=610d266582b, topicName=体脂)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=hb2008ye, createdTime=Wed Mar 24 15:55:08 CST 2021, time=2021-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=950621, encodeId=89cd950621ff, content=很棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3be85451515, createdName=ms3000001264084725, createdTime=Wed Mar 24 08:41:57 CST 2021, time=2021-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=950251, encodeId=b7ef950251c1, content=很有收获, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/1ReyQDb42vOics2FHYXlVv4onqAVCCoGgJFtRPfHHGMebZrZGHh77B1VVEahia8nPiaTaTq4icGxibJ7wLetml5FCBg/132, createdBy=9d3c2202243, createdName=Jo不是个男名, createdTime=Tue Mar 23 08:12:18 CST 2021, time=2021-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=950249, encodeId=6496950249f0, content=肥胖缺点多多, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b7a31928393, createdName=学医无涯, createdTime=Tue Mar 23 08:05:14 CST 2021, time=2021-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=950238, encodeId=44119502386e, content=所以每天跑步相当重要,锻炼身体才有革命的本钱啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9c6d5397190, createdName=ms8000001722700191, createdTime=Tue Mar 23 04:55:02 CST 2021, time=2021-03-23, status=1, ipAttribution=)]
    2021-03-23 ms8000001722700191

    所以每天跑步相当重要,锻炼身体才有革命的本钱啊

    0

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