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ACS Nano:纳米颗粒能直接载药入癌细胞核

2012-04-10 Beyond 生物谷

美国西北大学的科学家已经开发出一个简单的星形黄金纳米粒子可以将药物直接递送进入癌细胞的细胞核中。相关研究论文发表在ACS Nano杂志上。论文主要作者是Teri W. Odom博士。 科学家们正在越来越多地关注细胞水平上用纳米技术来对抗疾病。虽然纳米技术具有相当大的设计挑战性,但纳米技术是一种非常有前景的靶向治疗手段。 现在,西北大学研究团队首次发表报告称他们制造了一个简单的纳米粒子可以针

美国西北大学的科学家已经开发出一个简单的星形黄金纳米粒子可以将药物直接递送进入癌细胞的细胞核中。相关研究论文发表在ACS Nano杂志上。论文主要作者是Teri W. Odom博士。

科学家们正在越来越多地关注细胞水平上用纳米技术来对抗疾病。虽然纳米技术具有相当大的设计挑战性,但纳米技术是一种非常有前景的靶向治疗手段。

现在,西北大学研究团队首次发表报告称他们制造了一个简单的纳米粒子可以针对癌症细胞的细胞核,并能直接观察了纳米尺寸的微小物体与细胞核之间是如何交互作用的。

Odom是西北大学温伯格在艺术和科学学院的教授。她也是麦考密克工程和应用科学学院材料科学与工程教授。

对于他们的研究中,她和她的同事们共同研究了人类的子宫颈癌和卵巢癌的细胞。

他们利用电子显微镜观察药物纳米颗粒能极大地改变癌细胞的细胞核的形状。

他们注意到光滑、椭圆形的细胞核会变得凹凸不平,有深的褶皱。他们发现细胞核的形状变化与癌细胞的死亡和数量下降有关。

纳米粒子约25纳米宽、黄金材料制造。纳米颗粒的形状具有较大的表面积,使其能够携带高负荷浓缩的药物分子。

在这项研究中,研究人员利用一种称为AS1411的单链DNA适体。每个nanostar可以携带约1000股的适体药物,附着在其表面。

DNA适配子完成两项工作。首先是要结合“穿梭”的蛋白质核仁。第二就是nanostar释放药物。

黄金nanostars的另一个优点是生物相容性很好,这是普通纳米颗粒不具备的特点。

该新技术也可以在外科手术中使用的,一旦肿瘤切除,外科医生可以再使用黄金nanostars以消除癌细胞周围组织中杂散剩余的肿瘤细胞。(生物谷:Bioon)

doi:10.1021/nn300296p
PMC:
PMID:

Direct Observation of Nanoparticle-Cancer Cell Nucleus Interactions

Duncan Hieu M. Dam, Jung Heon Lee, Patrick N. Sisco, Dick T. Co, Ming Zhang, Michael R. Wasielewski, and Teri W. Odom

We report the direct visualization of interactions between drug-loaded nanoparticles and the cancer cell nucleus. Nanoconstructs composed of nucleolin-specific aptamers and gold nanostars were actively transported to the nucleus and induced major changes to the nuclear phenotype via nuclear envelope invaginations near the site of the construct. The number of local deformations could be increased by ultrafast, light-triggered release of the aptamers from the surface of the gold nanostars. Cancer cells with more nuclear envelope folding showed increased caspase 3 and 7 activity (apoptosis) as well as decreased cell viability. This newly revealed correlation between drug-induced changes in nuclear phenotype and increased therapeutic efficacy could provide new insight for nuclear-targeted cancer therapy.

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    2012-04-12 yxch36
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    2012-04-12 yaanren
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    2012-04-12 ying_wu

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