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Experimental Psychology:垃圾食品和高脂肪饮食对肾脏的损伤不亚于2型糖尿病

2016-05-13 MedSci MedSci原创

Experimental Psychology:垃圾食品高脂肪饮食对肾脏的损伤不亚于2型糖尿病如果对2型糖尿病管理不当则可引起严重的肾损伤。近日,据发表于Experimental Psychology的一项新的研究表明,摄入过量的垃圾食品或高脂肪饮食也导致同样地肾损伤。该研究结果表明高脂肪饮食或垃圾食品或可升高血糖的水平,其程度与2型糖尿病所致的类似。2型糖尿病是最常见的糖尿病类型,约占糖尿病的9

<如果对2型糖尿病管理不当则可引起严重的肾损伤。近日,据发表于Experimental Psychology的一项新的研究表明,摄入过量的垃圾食品或高脂肪饮食也导致同样会造成肾损伤。该研究结果表明高脂肪饮食或垃圾食品或可升高血糖的水平,其程度与2型糖尿病所致的类似。

2型糖尿病是最常见的糖尿病类型,约占糖尿病的90-95%。它是在机体不能有效利用胰岛素时发生的,机体无法有效利用胰岛素会导致血糖水平的升高。

若未经有效的治疗则随着时间的流逝血糖的浓度持续升高,到达一定程度时便可导致糖尿病肾病的发生,此时肾脏便无法清除体内代谢产物的。这主要是由于肾脏过度运转来清除体内过多的糖的原因。

该研究的领导者,英国安格利亚鲁斯金大学生物医学科学的高级讲师Havovi Chichger博士及其同事发现,摄入过量的垃圾食品或高脂肪饮食也可导致相似的后果。

高脂肪饮食、垃圾食品可增加大鼠葡萄糖受体的水平

研究人员将大鼠随机分组,分别接受高脂肪饮食——60%的脂肪含量,喂养5周;和垃圾食品——奶酪、巧克力、棉花糖,喂养8周。

评估这些饮食对大鼠血糖水平的影响,以及它们如何影响肾脏中各葡糖糖转运体。

然后,将得出的结果与1型或2型糖尿病大鼠比较。

结果发现,2型糖尿病大鼠的葡萄糖转运体GLUT和SGLT(葡萄糖的重吸收)及调节蛋白的水平较高。

葡萄糖的重吸收是指肾脏滤出葡萄糖并将其重吸收进入血液中的过程;如果血液中葡萄糖的水平过量超过肾脏重吸收的能力,那么这个过程则是无效的。

有趣的是,研究人员发现,高脂肪饮食或摄入垃圾食物的大鼠的GLUT和SGLT受体的数量也增多了,与2型糖尿病大鼠一样。

研究人员认为,该结果表明,与2型糖尿病患者一样,不健康饮食也是造成肾损伤的高危险因素,且程度相似。

Chichger博士认为,该研究结果或为降低血糖带来了一种新的治疗策略,即阻断肾脏中葡萄糖转运蛋白来降低血糖的水平。

了解饮食如何影响肾脏对糖的处理以及抑制剂是否可逆转这个改变,从而保护肾脏避免进一步的损伤。

原始出处:

Honor Whiteman. Junk food, high-fat diet may harm kidneys as much as type 2 diabetes. Wednesday 11 May 2016.

Havovi Chichger et al., Type II diabetes and related models of impaired glucose metabolism differentially regulate glucose transporters at the proximal tubule brush border membrane, Experimental Psychology, doi: 10.1113/EP085670, published online 11 May 2016.

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createdName=维他命, createdTime=Sun Oct 09 16:31:00 CST 2016, time=2016-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1389083, encodeId=94b21389083f5, content=<a href='/topic/show?id=d45c10262260' target=_blank style='color:#2F92EE;'>#高脂肪饮食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102622, encryptionId=d45c10262260, topicName=高脂肪饮食)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Sat May 14 15:31:00 CST 2016, time=2016-05-14, status=1, ipAttribution=)]
    2016-12-01 lixiaol
  4. 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createdBy=831a29654518, createdName=jinweidong, createdTime=Mon Jul 04 00:31:00 CST 2016, time=2016-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951987, encodeId=689a195198e16, content=<a href='/topic/show?id=04fa11552da' target=_blank style='color:#2F92EE;'>#Mental#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11552, encryptionId=04fa11552da, topicName=Mental)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=920c231, createdName=lixiaol, createdTime=Thu Dec 01 22:31:00 CST 2016, time=2016-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726094, encodeId=b4711e260947f, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu Dec 29 04:31:00 CST 2016, time=2016-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1792882, encodeId=548d1e92882e1, content=<a href='/topic/show?id=fcab14821c3' target=_blank style='color:#2F92EE;'>#Psychology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14821, encryptionId=fcab14821c3, topicName=Psychology)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd18451, createdName=xre2008, createdTime=Fri Dec 23 03:31:00 CST 2016, time=2016-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1785921, encodeId=70971e859218d, content=<a href='/topic/show?id=6a8ce16695' target=_blank style='color:#2F92EE;'>#Experiment#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7166, encryptionId=6a8ce16695, topicName=Experiment)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c49e75, createdName=qjddjq, createdTime=Mon Dec 19 18:31:00 CST 2016, time=2016-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140967, encodeId=b2ad14096ea0, content=文章真心很好,感谢作者, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Thu Oct 06 13:52:55 CST 2016, time=2016-10-06, status=1, ipAttribution=), 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createdName=维他命, createdTime=Sun Oct 09 16:31:00 CST 2016, time=2016-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1389083, encodeId=94b21389083f5, content=<a href='/topic/show?id=d45c10262260' target=_blank style='color:#2F92EE;'>#高脂肪饮食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102622, encryptionId=d45c10262260, topicName=高脂肪饮食)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Sat May 14 15:31:00 CST 2016, time=2016-05-14, status=1, ipAttribution=)]
    2016-12-29 feather89
  5. 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style='color:#2F92EE;'>#Experiment#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7166, encryptionId=6a8ce16695, topicName=Experiment)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c49e75, createdName=qjddjq, createdTime=Mon Dec 19 18:31:00 CST 2016, time=2016-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140967, encodeId=b2ad14096ea0, content=文章真心很好,感谢作者, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Thu Oct 06 13:52:55 CST 2016, time=2016-10-06, status=1, ipAttribution=), 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createdName=维他命, createdTime=Sun Oct 09 16:31:00 CST 2016, time=2016-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1389083, encodeId=94b21389083f5, content=<a href='/topic/show?id=d45c10262260' target=_blank style='color:#2F92EE;'>#高脂肪饮食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102622, encryptionId=d45c10262260, topicName=高脂肪饮食)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Sat May 14 15:31:00 CST 2016, time=2016-05-14, status=1, ipAttribution=)]
  6. 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style='color:#2F92EE;'>#Experiment#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7166, encryptionId=6a8ce16695, topicName=Experiment)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c49e75, createdName=qjddjq, createdTime=Mon Dec 19 18:31:00 CST 2016, time=2016-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=140967, encodeId=b2ad14096ea0, content=文章真心很好,感谢作者, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Thu Oct 06 13:52:55 CST 2016, time=2016-10-06, status=1, ipAttribution=), 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createdName=维他命, createdTime=Sun Oct 09 16:31:00 CST 2016, time=2016-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1389083, encodeId=94b21389083f5, content=<a href='/topic/show?id=d45c10262260' target=_blank style='color:#2F92EE;'>#高脂肪饮食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102622, encryptionId=d45c10262260, topicName=高脂肪饮食)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Sat May 14 15:31:00 CST 2016, time=2016-05-14, status=1, ipAttribution=)]
    2016-12-19 qjddjq
  7. 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createdBy=831a29654518, createdName=jinweidong, createdTime=Mon Jul 04 00:31:00 CST 2016, time=2016-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1951987, encodeId=689a195198e16, content=<a href='/topic/show?id=04fa11552da' target=_blank style='color:#2F92EE;'>#Mental#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11552, encryptionId=04fa11552da, topicName=Mental)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=920c231, createdName=lixiaol, createdTime=Thu Dec 01 22:31:00 CST 2016, time=2016-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726094, encodeId=b4711e260947f, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, 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createdName=维他命, createdTime=Sun Oct 09 16:31:00 CST 2016, time=2016-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1389083, encodeId=94b21389083f5, content=<a href='/topic/show?id=d45c10262260' target=_blank style='color:#2F92EE;'>#高脂肪饮食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102622, encryptionId=d45c10262260, topicName=高脂肪饮食)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Sat May 14 15:31:00 CST 2016, time=2016-05-14, status=1, ipAttribution=)]
    2016-10-06 1e10c84am36(暂无匿称)

    文章真心很好,感谢作者

    0

  8. 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createdName=维他命, createdTime=Sun Oct 09 16:31:00 CST 2016, time=2016-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1389083, encodeId=94b21389083f5, content=<a href='/topic/show?id=d45c10262260' target=_blank style='color:#2F92EE;'>#高脂肪饮食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102622, encryptionId=d45c10262260, topicName=高脂肪饮食)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Sat May 14 15:31:00 CST 2016, time=2016-05-14, status=1, ipAttribution=)]
    2016-08-29 ylzr123

    深入学习,好文值得点赞!

    0

  9. 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