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PLos One:组织学亚型与肺癌中的肌肉减少症无关

2018-03-29 xiangting MedSci原创

这项研究发现肌肉减少症与LCA中的老年、男性、晚期、合并症和低BMI显著相关。然而,组织学亚型并不是肌肉减少症存在的独立因素。

肌肉减少症很常见,并且是已知的肺癌(LCA)不良预后效应物。然而,LCA中肌肉减少症与组织学之间的关系仍不明确。

研究人员回顾性分析了2012年6月至2015年2月新诊断的LCA患者(n = 778),以确定与肌肉减少症相关的因素。肌肉减少症定义为CT确定的L3肌指数(L3的肌肉面积/身高2):男性<55cm 2/m2,女性<39cm2/m2。

患者平均年龄为67.7±10.8岁,大部分(73.1%)为男性。最常见的组织学类型是腺癌(44.0%),71.6%患者为III期或IV期。肌肉减少症的总患病率为48.2%(男性为60.3%,女性为15.3%)。单变量分析显示,肌肉减少症与男性,年龄(≥65岁),吸烟状况,较低的BMI(<23kg/m2),晚期(III和IV期)和高合并症评分(Charlson指数≥3)显著相关。此外,鳞状细胞癌(54.9%)和小细胞LCA(56.4%)的肌肉减少症的患病率高于腺癌(39.8%)。多变量分析显示,肌肉减少症与男性(OR,11.13),老年人(OR,2.02)和低BMI(OR,6.28),IV期(OR,1.98)和高合并症(OR, 1.93)独立相关。然而,没有发现组织学亚型和肌肉减少症之间存在显著关联。

这项研究发现肌肉减少症与LCA中的老年、男性、晚期、合并症和低BMI显著相关。然而,组织学亚型并不是肌肉减少症存在的独立因素。

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