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Lancet:全球32个国家的脑卒中危险因素分析(INTERSTROKE)

2016-07-16 Seven L 译 MedSci原创

背景:卒中是导致死亡和残疾的主要原因,尤其是在低收入和中等收入国家。我们试图量化不同地区、重点人群和卒中主要病理亚型的脑卒中的重要性和潜在危险因素。方法:我们在亚洲、美国、欧洲、澳大利亚、中东和非洲的32个国家,完成了一个标准化的国际病例对照研究。病例均为首发急性脑卒中患者(症状发生5天内入院,入院时内72小时纳入研究)。对照组对按1:1纳入的没有卒中病史、年龄和性别相匹配的个体。对所有参与者进行

背景:卒中是导致死亡和残疾的主要原因,尤其是在低收入和中等收入国家。我们试图量化不同地区、重点人群和卒中主要病理亚型的脑卒中的重要性和潜在危险因素。方法:我们在亚洲、美国、欧洲、澳大利亚、中东和非洲的32个国家,完成了一个标准化的国际病例对照研究。病例均为首发急性脑卒中患者(症状发生5天内入院,入院时内72小时纳入研究)。对照组对按1:1纳入的没有卒中病史、年龄和性别相匹配的个体。对所有参与者进行临床评估,以及参与者提供血液和尿液样本。结果:在2007年1月11日-2015年8月8日期间,共纳入了来自32个国家的26919名参与者,其中13447名患者(10388名为缺血性卒中患者,3059名为脑出血患者)和13472名对照个体。与所有卒中相关的因素如下:既往高血压病史或血压≥140/90 mm Hg(OR 2.98, 99% CI 2.72–3.28; PAR 47.9%, 99% CI 45.1–50.6)、规律运动(0.60, 0.52–0.70; 35.8%, 27.7–44.7)、载脂蛋白(Apo)B/ApoA1比值(最高三分位组与最低组相比 1.84, 1.65–2.06;

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    2017-02-18 仁者大医
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    2017-01-23 howi
  4. [GetPortalCommentsPageByObjectIdResponse(id=1716313, encodeId=aa8c1e16313d5, content=<a href='/topic/show?id=464a84e5307' target=_blank style='color:#2F92EE;'>#脑卒中危险因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84753, encryptionId=464a84e5307, topicName=脑卒中危险因素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd9732204770, createdName=yese, createdTime=Tue Feb 21 13:40:00 CST 2017, time=2017-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1878176, encodeId=ec7118e8176aa, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Sat Feb 18 16:40:00 CST 2017, time=2017-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1828538, encodeId=bafb1828538dd, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Mon Jan 23 16:40:00 CST 2017, time=2017-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145555, encodeId=1638145555dc, content=好文,值得推荐。, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Oct 11 20:34:50 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=135136, encodeId=7001135136bf, content=文章很好值得关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Sep 25 17:24:00 CST 2016, time=2016-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93796, encodeId=066d93e9684, content=脑卒中确实很可怕!, beContent=null, objectType=article, channel=null, level=null, likeNumber=174, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Wed Jul 20 12:06:00 CST 2016, time=2016-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93377, encodeId=80eb933e720, content=继续分享美文, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Mon Jul 18 19:34:00 CST 2016, time=2016-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93375, encodeId=dc07933e5fc, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Mon Jul 18 19:33:00 CST 2016, time=2016-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93376, encodeId=c41a933e689, content=好文章大家共享, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Mon Jul 18 19:33:00 CST 2016, time=2016-07-18, status=1, ipAttribution=)]
    2016-10-11 ylzr123

    好文,值得推荐。

    0

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    2016-09-25 1e10c84am36(暂无匿称)

    文章很好值得关注

    0

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    2016-07-20 1dd8c52fm63(暂无匿称)

    脑卒中确实很可怕!

    0

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    2016-07-18 doctorJiangchao

    继续分享美文

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1716313, encodeId=aa8c1e16313d5, content=<a href='/topic/show?id=464a84e5307' target=_blank style='color:#2F92EE;'>#脑卒中危险因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84753, encryptionId=464a84e5307, topicName=脑卒中危险因素)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd9732204770, createdName=yese, createdTime=Tue Feb 21 13:40:00 CST 2017, time=2017-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1878176, encodeId=ec7118e8176aa, content=<a href='/topic/show?id=c157696175' target=_blank style='color:#2F92EE;'>#ERS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6961, encryptionId=c157696175, topicName=ERS)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Sat Feb 18 16:40:00 CST 2017, time=2017-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1828538, encodeId=bafb1828538dd, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Mon Jan 23 16:40:00 CST 2017, time=2017-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145555, encodeId=1638145555dc, content=好文,值得推荐。, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Tue Oct 11 20:34:50 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=135136, encodeId=7001135136bf, content=文章很好值得关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Sep 25 17:24:00 CST 2016, time=2016-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93796, encodeId=066d93e9684, content=脑卒中确实很可怕!, beContent=null, objectType=article, channel=null, level=null, likeNumber=174, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Wed Jul 20 12:06:00 CST 2016, time=2016-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93377, encodeId=80eb933e720, content=继续分享美文, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Mon Jul 18 19:34:00 CST 2016, time=2016-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93375, encodeId=dc07933e5fc, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Mon Jul 18 19:33:00 CST 2016, time=2016-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93376, encodeId=c41a933e689, content=好文章大家共享, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Mon Jul 18 19:33:00 CST 2016, time=2016-07-18, status=1, ipAttribution=)]
    2016-07-18 doctorJiangchao

    继续学习

    0

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    2016-07-18 doctorJiangchao

    好文章大家共享

    0

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