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World J Gastroenterol:牙周炎合并吸烟会增加溃疡性结肠炎的发病风险

2021-07-08 MedSci原创 MedSci原创

牙周炎是一种牙周组织的慢性炎症。牙周炎对炎症性肠病(IBD)发展的影响仍不清楚。近日,研究人员评估了牙周炎患者发生IBD的风险,以及与牙周炎有关的IBD风险因素,研究结果已发表于World J Gas

牙周炎是一种牙周组织的慢性炎症。牙周炎对炎症性肠病(IBD)发展的影响仍不清楚。近日,研究人员评估了牙周炎患者发生IBD的风险,以及与牙周炎有关的IBD风险因素,研究结果已发表于World J Gastroenterol。

利用韩国国家健康保险服务的索赔数据,进行了一项全国性的基于人口的队列研究。总共纳入了9950548名年龄≥20岁的人,他们在2009年接受了全国健康检查。使用国际疾病分类第10次修订版和罕见难治性疾病便秘对比牙周炎组和非牙周炎组新诊断的IBD[克罗恩病(CD)、溃疡性结肠炎(UC)]。

 

结果,共有1092825人(11.0%)患有牙周炎。牙周炎与年龄较大、男性、较高的身体质量指数、戒烟、不饮酒和经常锻炼有密切关系。牙周炎组的平均年龄为51.4±12.9岁,非牙周炎组为46.6±14.2岁(P<0.01)。牙周炎组和非牙周炎组的平均体重指数分别为23.9±3.1和23.7±3.2(P < 0.01)。牙周炎组和非牙周炎组中男性分别为604307(55.3%)和4844383(54.7%)。平均随访时间为7.26年。牙周炎患者UC的风险明显高于无牙周炎组[校正后的HR:1.091;95% CI:1.008-1.182],但CD并没有(校正后的HR:0.879;95% CI:0.731-1.057)。在年龄≥65岁、男性、饮酒者、当前吸烟者和体力活动减少的亚组中,UC的风险显著。年龄≥65岁的参与者中,牙周炎的当前吸烟者患UC的风险比非牙周炎的非吸烟者增加1.9倍。

综上,牙周炎与患UC的风险显著相关,但与CD无关,特别是在年龄≥65岁的当前吸烟者中。

 

原始出处:

 

Eun Ae Kang, et al., Periodontitis combined with smoking increases risk of the ulcerative colitis: A national cohort study. World J Gastroenterol. 2020 Oct 7;26(37):5661-5672. doi: 10.3748/wjg.v26.i37.5661.

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    2021-12-14 许安
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    2021-11-28 nymo
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    2021-11-08 1482963am12暂无昵称

    学习了

    0

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    2021-07-30 DR.Fu SIR

    戒烟,注意口腔卫生

    0

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