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世界帕金森病日：帕友该关心的三个问题

2016-04-11 @健康中国 新浪微博@健康中国

帕金森老年痴呆
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  1. [GetPortalCommentsPageByObjectIdResponse(id=130406, encodeId=03be13040699, content=文章有深度，赞一个。深入学习探讨。, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Sep 18 16:56:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78024, encodeId=62ace8024e2, content=高大上的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Thu Apr 14 18:19:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78025, encodeId=1ca5e802510, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Thu Apr 14 18:19:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=77628, encodeId=ca99e7628fe, content=不好处理的病、搞得多久没有什么进展！, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xSHQO6hUsLfmSqiaQiceT0D77ib0rXiblAIwyTo0iciakSAGHE0nfEpNHl9icHMY6tKTW3kFdWSwKcWGvneZHicqoJsI5V/0, createdBy=2a221626427, createdName=王新春, createdTime=Wed Apr 13 10:48:00 CST 2016, time=2016-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=77560, encodeId=81aae7560a0, content=关心发病机制, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/22A0087C508319009C3494AF668D84F6/100, createdBy=3b061711895, createdName=南塘隐9d53fba6, createdTime=Tue Apr 12 22:28:00 CST 2016, time=2016-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=77515, encodeId=e98ee751504, content=多关注患者的生活质量。, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160313/IMG56E50DEC424F44672.jpg, createdBy=ce5b1699635, createdName=Lisa971, createdTime=Tue Apr 12 14:26:00 CST 2016, time=2016-04-12, status=1, ipAttribution=)]
    2016-09-18 ylzr123

    文章有深度，赞一个。深入学习探讨。

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=130406, encodeId=03be13040699, content=文章有深度，赞一个。深入学习探讨。, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Sep 18 16:56:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78024, encodeId=62ace8024e2, content=高大上的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Thu Apr 14 18:19:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78025, encodeId=1ca5e802510, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Thu Apr 14 18:19:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=77628, encodeId=ca99e7628fe, content=不好处理的病、搞得多久没有什么进展！, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xSHQO6hUsLfmSqiaQiceT0D77ib0rXiblAIwyTo0iciakSAGHE0nfEpNHl9icHMY6tKTW3kFdWSwKcWGvneZHicqoJsI5V/0, createdBy=2a221626427, createdName=王新春, createdTime=Wed Apr 13 10:48:00 CST 2016, time=2016-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=77560, encodeId=81aae7560a0, content=关心发病机制, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/22A0087C508319009C3494AF668D84F6/100, createdBy=3b061711895, createdName=南塘隐9d53fba6, createdTime=Tue Apr 12 22:28:00 CST 2016, time=2016-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=77515, encodeId=e98ee751504, content=多关注患者的生活质量。, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160313/IMG56E50DEC424F44672.jpg, createdBy=ce5b1699635, createdName=Lisa971, createdTime=Tue Apr 12 14:26:00 CST 2016, time=2016-04-12, status=1, ipAttribution=)]
    2016-04-14 李继凯

    高大上的文章

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=130406, encodeId=03be13040699, content=文章有深度，赞一个。深入学习探讨。, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Sep 18 16:56:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78024, encodeId=62ace8024e2, content=高大上的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Thu Apr 14 18:19:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78025, encodeId=1ca5e802510, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Thu Apr 14 18:19:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=77628, encodeId=ca99e7628fe, content=不好处理的病、搞得多久没有什么进展！, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xSHQO6hUsLfmSqiaQiceT0D77ib0rXiblAIwyTo0iciakSAGHE0nfEpNHl9icHMY6tKTW3kFdWSwKcWGvneZHicqoJsI5V/0, createdBy=2a221626427, createdName=王新春, createdTime=Wed Apr 13 10:48:00 CST 2016, time=2016-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=77560, encodeId=81aae7560a0, content=关心发病机制, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/22A0087C508319009C3494AF668D84F6/100, createdBy=3b061711895, createdName=南塘隐9d53fba6, createdTime=Tue Apr 12 22:28:00 CST 2016, time=2016-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=77515, encodeId=e98ee751504, content=多关注患者的生活质量。, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160313/IMG56E50DEC424F44672.jpg, createdBy=ce5b1699635, createdName=Lisa971, createdTime=Tue Apr 12 14:26:00 CST 2016, time=2016-04-12, status=1, ipAttribution=)]
    2016-04-14 李继凯

    值得学习

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=130406, encodeId=03be13040699, content=文章有深度，赞一个。深入学习探讨。, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Sep 18 16:56:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78024, encodeId=62ace8024e2, content=高大上的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Thu Apr 14 18:19:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78025, encodeId=1ca5e802510, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Thu Apr 14 18:19:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=77628, encodeId=ca99e7628fe, content=不好处理的病、搞得多久没有什么进展！, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xSHQO6hUsLfmSqiaQiceT0D77ib0rXiblAIwyTo0iciakSAGHE0nfEpNHl9icHMY6tKTW3kFdWSwKcWGvneZHicqoJsI5V/0, createdBy=2a221626427, createdName=王新春, createdTime=Wed Apr 13 10:48:00 CST 2016, time=2016-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=77560, encodeId=81aae7560a0, content=关心发病机制, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/22A0087C508319009C3494AF668D84F6/100, createdBy=3b061711895, createdName=南塘隐9d53fba6, createdTime=Tue Apr 12 22:28:00 CST 2016, time=2016-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=77515, encodeId=e98ee751504, content=多关注患者的生活质量。, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160313/IMG56E50DEC424F44672.jpg, createdBy=ce5b1699635, createdName=Lisa971, createdTime=Tue Apr 12 14:26:00 CST 2016, time=2016-04-12, status=1, ipAttribution=)]
    2016-04-13 王新春

    不好处理的病、搞得多久没有什么进展！

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=130406, encodeId=03be13040699, content=文章有深度，赞一个。深入学习探讨。, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Sep 18 16:56:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78024, encodeId=62ace8024e2, content=高大上的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Thu Apr 14 18:19:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78025, encodeId=1ca5e802510, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Thu Apr 14 18:19:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=77628, encodeId=ca99e7628fe, content=不好处理的病、搞得多久没有什么进展！, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xSHQO6hUsLfmSqiaQiceT0D77ib0rXiblAIwyTo0iciakSAGHE0nfEpNHl9icHMY6tKTW3kFdWSwKcWGvneZHicqoJsI5V/0, createdBy=2a221626427, createdName=王新春, createdTime=Wed Apr 13 10:48:00 CST 2016, time=2016-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=77560, encodeId=81aae7560a0, content=关心发病机制, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/22A0087C508319009C3494AF668D84F6/100, createdBy=3b061711895, createdName=南塘隐9d53fba6, createdTime=Tue Apr 12 22:28:00 CST 2016, time=2016-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=77515, encodeId=e98ee751504, content=多关注患者的生活质量。, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160313/IMG56E50DEC424F44672.jpg, createdBy=ce5b1699635, createdName=Lisa971, createdTime=Tue Apr 12 14:26:00 CST 2016, time=2016-04-12, status=1, ipAttribution=)]
    2016-04-12 南塘隐9d53fba6

    关心发病机制

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=130406, encodeId=03be13040699, content=文章有深度，赞一个。深入学习探讨。, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Sep 18 16:56:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78024, encodeId=62ace8024e2, content=高大上的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Thu Apr 14 18:19:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78025, encodeId=1ca5e802510, content=值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=141, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=240a1683959, createdName=李继凯, createdTime=Thu Apr 14 18:19:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=77628, encodeId=ca99e7628fe, content=不好处理的病、搞得多久没有什么进展！, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xSHQO6hUsLfmSqiaQiceT0D77ib0rXiblAIwyTo0iciakSAGHE0nfEpNHl9icHMY6tKTW3kFdWSwKcWGvneZHicqoJsI5V/0, createdBy=2a221626427, createdName=王新春, createdTime=Wed Apr 13 10:48:00 CST 2016, time=2016-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=77560, encodeId=81aae7560a0, content=关心发病机制, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://q.qlogo.cn/qqapp/101296147/22A0087C508319009C3494AF668D84F6/100, createdBy=3b061711895, createdName=南塘隐9d53fba6, createdTime=Tue Apr 12 22:28:00 CST 2016, time=2016-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=77515, encodeId=e98ee751504, content=多关注患者的生活质量。, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160313/IMG56E50DEC424F44672.jpg, createdBy=ce5b1699635, createdName=Lisa971, createdTime=Tue Apr 12 14:26:00 CST 2016, time=2016-04-12, status=1, ipAttribution=)]
    2016-04-12 Lisa971

    多关注患者的生活质量。

    0

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（图片摘自www.sciencealert.com） 我们理所当然地认为全世界的科学成果都是由优秀，诚实，努力的研究者们做出的，他们把根据标准的试验手段、科学的试验方法得出的，而且会谨慎地把自己认为正确的结果发表在科学期刊上与大众交流。然而，学术界与任何一个领域一样，总有坏的地方存在。 这里就有一个鲜活的例子：澳大利亚神经学家Bruce Murdoch由于伪造数据，制造了帕金森症领域的所

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近期发表在JAMA Neurology的研究称，对帕金森患者常用的抗精神病药可能会造成额外伤害。抗精神病药物潜在的不良影响包括：降低警觉性、更高的糖尿病和心脏病的风险、低血压，长期而言还会导致类似帕金森的运动障碍。研究表明，高达60%的帕金森患者有精神病，80%的患者有痴呆。而先前有研究表明，抗精神病药物会增加痴呆患者的死亡风险。FDA也指出了抗精神病药物对痴呆患者的风险。早在2011年，Dani

JAMA Neurol：酒渣鼻会增加帕金森风险

近期发表在JAMA Neurology的研究称，酒渣鼻可以通过共同的致病机制导致帕金森病！酒渣鼻又称玫瑰痤疮，是一种慢性皮肤病，以脸上发红、丘疹为特征，有时候会涉及到研究；此外，该疾病还会引起皮肤的增厚。中老年人，尤其是围绝经期女性，更容易患上该疾病。皮肤白皙的人也更容易得该病。不过该疾病的病因尚不明确，有研究称基质金属蛋白酶的活性与该疾病的发生发展有关。丹麦哥本哈根大学的Alexander Eg

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背景：帕金森病（PD）神经保护作用尚解释不清。生物标志物的研究有助于治疗的进展。因此，神经系统疾病和卒中的国家研究所，建立了帕金森病的生物标志物计划，以促进发现的帕金森病生物标志物在二期和三期临床试验中使用的。方法：应用新型的涉及，帕金森病的生物标志物计划的重点是：PD诊断，进展和预后的临床和实验室生物标记物的发展。标准化操作流程和汇集样本，以便进行跨项目比较和处理相关的评估。基于网络的数据处理资

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