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Eur Heart J:体重和体重变化与房颤风险

2019-06-18 xing.T 网络

由此可见,长期肥胖和BMI变化与AF风险有关。即使在考虑到近期的BMI之后,生命早期的肥胖和体重增加随着时间的推移对AF发生发展产生累积效应。

尽管肥胖与心房颤动(AF)的风险有关,但长期肥胖、近期肥胖和体重变化与整个成年期AF风险的相关性尚不确定。

近日,心血管领域权威杂志Eur Heart J上发表了一篇研究文章,研究人员进行了一项队列研究,其中纳入了15214名参与者。该队列创建于2006年至2008年(基线),随访AF事件直至2015年。在基线时直接测量体重和身高。从基线前10年、20年和40年进行的测量中回顾性地检索先前体重和身高的数据。研究人员计算了随时间变化的平均体重指数(BMI)和体重变化。

在随访期间,1149名参与者发展为AF患者。与正常体重相比,对于平均BMI为25.0-29.9 kg/m2的参与者多变量校正风险比为1.2(95%置信区间为1.0-1.4),,平均BMI≥30kg/m2的参与者为1.6(1.2-2.0)。在调整最近的BMI后,平均B​​MI与AF风险的关联仅略微减弱。相比之下,在调整生命早期的平均BMI后,目前的BMI与AF风险相关性并不密切。与稳定的BMI相比,BMI减少和增加都与AF风险增加有关。在调整最近的BMI后,BMI增加与AF风险的关联基本没有变化,而BMI减少与AF风险的关联减弱。

由此可见,长期肥胖和BMI变化与AF风险有关。即使在考虑到近期的BMI之后,生命早期的肥胖和体重增加随着时间的推移对AF发生发展产生累积效应。 

原始出处:

Tingting Feng.et al.Weight and weight change and risk of atrial fibrillation: the HUNT study.Eur Heart J. https://doi.org/10.1093/eurheartj/ehz390

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    2019-06-20 zhaojie88
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    2019-06-20 slcumt

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