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BMJ:住宅交通噪音暴露与痴呆发病率的关系

2021-09-16 MedSci原创 MedSci原创

交通噪音与全因痴呆和痴呆亚型的风险升高有关,尤其是阿尔茨海默病。

近日,顶级杂志BMJ上发表了一篇研究文章,该研究旨在调查住宅长期暴露于道路交通和铁路噪音与痴呆事件风险之间的关联。


该研究为基于丹麦全国前瞻性登记处开展的队列研究,参与者为1938994名60岁以上的成年人,他们在2004年1月1日至2017年12月31日期间居住在丹麦。

该研究的主要结局指标为从国立医院和处方登记处确定的全因痴呆和痴呆亚型(阿尔茨海默病、血管性痴呆和帕金森病相关痴呆)病例。


研究人群包括103500名痴呆症患者,其中31219人被诊断为阿尔茨海默病,8664人被诊断为血管性痴呆,2192人被诊断为帕金森病相关痴呆。研究人员使用Cox回归模型分析了建筑物外墙10年平均暴露于最多(Ldenmax)和最少(Ldenmin)道路交通和铁路噪音与更高的全因痴呆风险相关。这些关联显示出噪声暴露较高时痴呆风险比较高的一般模式,但在较高噪声水平下风险趋于平稳甚至小幅下降。在亚型分析中,道路交通噪声和铁路噪声都与更高的阿尔茨海默病风险相关,公路Ldenmax≥65dB与<45dB相比,痴呆风险比为1.16(95%置信区间为1.11至1.22),公路Ldenmin≥55dB与<40dB相比,痴呆风险比为1.27(1.22至1.34);铁路Ldenmax≥60dB与<40dB相比,痴呆风险比为1.16(1.10至1.23),铁路Ldenmin≥50dB与<40Db相比,痴呆风险比为1.24(1.17至1.30)。公路交通,而不是铁路,噪音与血管性痴呆风险增加相关。这些结果表明道路交通Ldenmin与帕金森病相关痴呆之间存在关联。
 
这项全国性队列研究结果表明,交通噪音与全因痴呆和痴呆亚型的风险升高有关,尤其是阿尔茨海默病。

原始出处:

Manuella Lech Cantuaria,et al.Residential exposure to transportation noise in Denmark and incidence of dementia: national cohort study.BMJ.2021;https://www.bmj.com/content/374/bmj.n1954

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    2022-04-02 gaoxiaoe
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    2021-09-18 yuandd
  5. [GetPortalCommentsPageByObjectIdResponse(id=1849306, encodeId=e32918493066b, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Sat Apr 02 15:50:09 CST 2022, time=2022-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1936905, encodeId=031919369059e, content=<a href='/topic/show?id=b7c62438600' target=_blank style='color:#2F92EE;'>#交通噪音#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24386, encryptionId=b7c62438600, topicName=交通噪音)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d47b2500175, createdName=12498cf9m35(暂无昵称), createdTime=Sun Jan 02 09:50:09 CST 2022, time=2022-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1823750, encodeId=0d791823e505a, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Sun Mar 20 14:50:09 CST 2022, time=2022-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588868, encodeId=043415888686c, content=<a href='/topic/show?id=00742438078' target=_blank style='color:#2F92EE;'>#交通#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24380, encryptionId=00742438078, topicName=交通)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=84fb17623791, createdName=yuandd, createdTime=Sat Sep 18 11:50:09 CST 2021, time=2021-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1052228, encodeId=dda1105222851, content=改善住宅环境, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=821f2227826, createdName=DR.Fu SIR, createdTime=Fri Sep 17 08:54:01 CST 2021, time=2021-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1052754, encodeId=b44e1052e5422, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Thu Sep 16 23:50:09 CST 2021, time=2021-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1246284, encodeId=653c124628412, content=老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Thu Sep 16 23:50:09 CST 2021, time=2021-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1052103, encodeId=71f1105210373, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=58c55294961, createdName=1487042cm12暂无昵称, createdTime=Thu Sep 16 21:57:30 CST 2021, time=2021-09-16, status=1, ipAttribution=)]
    2021-09-17 DR.Fu SIR

    改善住宅环境

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1849306, encodeId=e32918493066b, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Sat Apr 02 15:50:09 CST 2022, time=2022-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1936905, encodeId=031919369059e, content=<a href='/topic/show?id=b7c62438600' target=_blank style='color:#2F92EE;'>#交通噪音#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24386, encryptionId=b7c62438600, topicName=交通噪音)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d47b2500175, createdName=12498cf9m35(暂无昵称), createdTime=Sun Jan 02 09:50:09 CST 2022, time=2022-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1823750, encodeId=0d791823e505a, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Sun Mar 20 14:50:09 CST 2022, time=2022-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588868, encodeId=043415888686c, content=<a href='/topic/show?id=00742438078' target=_blank style='color:#2F92EE;'>#交通#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24380, encryptionId=00742438078, topicName=交通)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=84fb17623791, createdName=yuandd, createdTime=Sat Sep 18 11:50:09 CST 2021, time=2021-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1052228, encodeId=dda1105222851, content=改善住宅环境, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=821f2227826, createdName=DR.Fu SIR, createdTime=Fri Sep 17 08:54:01 CST 2021, time=2021-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1052754, encodeId=b44e1052e5422, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Thu Sep 16 23:50:09 CST 2021, time=2021-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1246284, encodeId=653c124628412, content=老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Thu Sep 16 23:50:09 CST 2021, time=2021-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1052103, encodeId=71f1105210373, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=58c55294961, createdName=1487042cm12暂无昵称, createdTime=Thu Sep 16 21:57:30 CST 2021, time=2021-09-16, status=1, ipAttribution=)]
    2021-09-16 junJUN

    老年人痴呆何药可用??

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1849306, encodeId=e32918493066b, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Sat Apr 02 15:50:09 CST 2022, time=2022-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1936905, encodeId=031919369059e, content=<a href='/topic/show?id=b7c62438600' target=_blank style='color:#2F92EE;'>#交通噪音#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24386, encryptionId=b7c62438600, topicName=交通噪音)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d47b2500175, createdName=12498cf9m35(暂无昵称), createdTime=Sun Jan 02 09:50:09 CST 2022, time=2022-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1823750, encodeId=0d791823e505a, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Sun Mar 20 14:50:09 CST 2022, time=2022-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588868, encodeId=043415888686c, content=<a href='/topic/show?id=00742438078' target=_blank style='color:#2F92EE;'>#交通#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24380, encryptionId=00742438078, topicName=交通)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=84fb17623791, createdName=yuandd, createdTime=Sat Sep 18 11:50:09 CST 2021, time=2021-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1052228, encodeId=dda1105222851, content=改善住宅环境, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=821f2227826, createdName=DR.Fu SIR, createdTime=Fri Sep 17 08:54:01 CST 2021, time=2021-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1052754, encodeId=b44e1052e5422, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Thu Sep 16 23:50:09 CST 2021, time=2021-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1246284, encodeId=653c124628412, content=老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Thu Sep 16 23:50:09 CST 2021, time=2021-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1052103, encodeId=71f1105210373, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=58c55294961, createdName=1487042cm12暂无昵称, createdTime=Thu Sep 16 21:57:30 CST 2021, time=2021-09-16, status=1, ipAttribution=)]
    2021-09-16 neuro.Dr

    老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1849306, encodeId=e32918493066b, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Sat Apr 02 15:50:09 CST 2022, time=2022-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1936905, encodeId=031919369059e, content=<a href='/topic/show?id=b7c62438600' target=_blank style='color:#2F92EE;'>#交通噪音#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24386, encryptionId=b7c62438600, topicName=交通噪音)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d47b2500175, createdName=12498cf9m35(暂无昵称), createdTime=Sun Jan 02 09:50:09 CST 2022, time=2022-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1823750, encodeId=0d791823e505a, content=<a href='/topic/show?id=b2873e9220e' target=_blank style='color:#2F92EE;'>#发病率#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37922, encryptionId=b2873e9220e, topicName=发病率)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa0e14, createdName=lifestar, createdTime=Sun Mar 20 14:50:09 CST 2022, time=2022-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588868, encodeId=043415888686c, content=<a href='/topic/show?id=00742438078' target=_blank style='color:#2F92EE;'>#交通#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24380, encryptionId=00742438078, topicName=交通)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=84fb17623791, createdName=yuandd, createdTime=Sat Sep 18 11:50:09 CST 2021, time=2021-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1052228, encodeId=dda1105222851, content=改善住宅环境, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=821f2227826, createdName=DR.Fu SIR, createdTime=Fri Sep 17 08:54:01 CST 2021, time=2021-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1052754, encodeId=b44e1052e5422, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Thu Sep 16 23:50:09 CST 2021, time=2021-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1246284, encodeId=653c124628412, content=老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Thu Sep 16 23:50:09 CST 2021, time=2021-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1052103, encodeId=71f1105210373, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=58c55294961, createdName=1487042cm12暂无昵称, createdTime=Thu Sep 16 21:57:30 CST 2021, time=2021-09-16, status=1, ipAttribution=)]
    2021-09-16 1487042cm12暂无昵称

    学习

    0

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