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BMJ Open:温度每升高1 ℃,预计有10万人新发糖尿病

2017-10-24 许菁 中国循环杂志

全球气温升高可能会对当前全球糖尿病流行产生影响。近期有研究者分析了美国14年的数据, 发现总体糖尿病发病率在较暖年份较高。

全球气温升高可能会对当前全球糖尿病流行产生影响。近期有研究者分析了美国14年的数据, 发现总体糖尿病发病率在较暖年份较高。

据研究者统计,在美国,环境温度每升高1 ℃,预计有10万例新发糖尿病

同样,在全球范围内,在温暖的国家葡萄糖不耐受的患病率较高。

环境温度每升高1 ℃,校正的葡萄糖不耐受患病率增加了 0.17%。

而且研究者发现,温度升高对糖尿病和葡萄糖耐受的影响与体重无关。其机制可能与褐色脂肪活性与葡萄糖代谢的相互作用有关

研究者指出,在生理上,温度降低会激活褐色脂肪的活性,进而燃烧大量的脂质以产生热量,这是一种很重要的保护机体、抵御寒冷的机制,而在温暖的环境下,褐色脂肪将不会被激活,不利于糖代谢,这是胰岛素抵抗乃至糖尿病发生的原因。

有研究发现,2 型糖尿病患者在冷的环境中待10天后,其胰岛素敏感性明显增加,而体重不受影响。

同样另一项研究表明, 在冷暴露后,褐色脂肪的活性升高导致血糖和HbA1c水平降低,且与体重变化无关。

温度对褐色脂肪活性的影响导致影响糖尿病发病,可能也存在遗传因素。

除了褐色脂肪活性,体力活动或许也参与其中。体力活动也会随环境温度的变化而变化,还有待进一步研究。

原始出处: Blauw LL, N Ahmad Aziz, Martijn R Tannemaat, et al. Diabetes incidence and glucose intolerance prevalence increase with higher outdoor temperature. BMJ Open Diabetes Res Care, 2017

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    2018-06-13 gaoxiaoe
  2. [GetPortalCommentsPageByObjectIdResponse(id=1848394, encodeId=77f118483946f, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Wed Jun 13 18:28:00 CST 2018, time=2018-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726823, encodeId=967a1e268238e, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sat Mar 24 18:28:00 CST 2018, time=2018-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255883, encodeId=97a0255883b3, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Wed Oct 25 16:19:13 CST 2017, time=2017-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255716, encodeId=3b7e255e16b6, content=谢谢分享谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Wed Oct 25 00:31:20 CST 2017, time=2017-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255653, encodeId=c5fa255653b6, content=不是吧.要好好研究下, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Tue Oct 24 19:19:05 CST 2017, time=2017-10-24, status=1, ipAttribution=)]
    2018-03-24 feather89
  3. [GetPortalCommentsPageByObjectIdResponse(id=1848394, encodeId=77f118483946f, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Wed Jun 13 18:28:00 CST 2018, time=2018-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726823, encodeId=967a1e268238e, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sat Mar 24 18:28:00 CST 2018, time=2018-03-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255883, encodeId=97a0255883b3, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfBfgWn9nXBgH1sNSiaOAKhsKpN40jDHQKqcRzovau5VibLvREN8uxnu9sKoScBicHSiaDMmbveibFdrBiaD4k4IOPwlG/0, createdBy=b5d11730951, createdName=Jackie Li, createdTime=Wed Oct 25 16:19:13 CST 2017, time=2017-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255716, encodeId=3b7e255e16b6, content=谢谢分享谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好!, createdTime=Wed Oct 25 00:31:20 CST 2017, time=2017-10-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255653, encodeId=c5fa255653b6, content=不是吧.要好好研究下, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Tue Oct 24 19:19:05 CST 2017, time=2017-10-24, status=1, ipAttribution=)]
    2017-10-25 Jackie Li

    学习

    0

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    2017-10-25 明天会更好!

    谢谢分享谢谢分享

    0

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    2017-10-24 惠映实验室

    不是吧.要好好研究下

    0

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