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JAHA:与静脉血栓栓塞风险相关的代谢物

2018-11-17 xing.T MedSci原创

由此可见,尽管该研究的结果表明循环代谢物可能会影响VTE发生的风险,但可以观察到的相关性却被体重指数所混淆。需要进行更多个体参与和覆盖更广泛代谢组学的研究来进一步证实这些研究结果。

静脉血栓栓塞(VTE)是一种复杂的血栓性疾病,是死亡率和发病率的主要来源。近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,为了进一步了解VTE的病因,研究人员在病例对照研究中进行了代谢组学分析,该研究纳入了240例VTE病例和6963例对照者,这些参与者嵌套在3个基于人群的大型队列中,即护士健康研究、护士健康研究II 以及卫生专业人员的后续研究。

对于每个个体,研究人员测量了211种代谢物并收集了有关生活方式因素的详细信息,并进行了Logistic回归和富集分析,以确定与事件性VTE风险相关的代谢物和生物类别,考虑的关键混杂因素包含年龄、性别、吸烟、饮酒、体重指数和合并疾病(如癌症)。

研究人员对所有VTE患者进行了分析,并对肺栓塞患者进行了单独分析。使用控制年龄、性别和原发疾病的基本模型,研究人员确定了60个显著的与VTE或肺栓塞相关代谢物(P<0.05)。这些代谢物富集于二酰基甘油(P<0.05)。然而,在控制多次检测后,仅有1种代谢物(C5肉毒碱;比值比为1.25; 95%置信区间为1.10-1.41; P=0.03)与VTE显著相关。在进一步调整体重指数后,在进行多次检测后,没有代谢物与疾病显著相关,并且没有哪种代谢物为名义上显著的关联而富集。

由此可见,尽管该研究的结果表明循环代谢物可能会影响VTE发生的风险,但可以观察到的相关性却被体重指数所混淆。需要进行更多个体参与和覆盖更广泛代谢组学的研究来进一步证实这些研究结果。

原始出处:

Xia Jiang.et al.Metabolites Associated With the Risk of Incident Venous Thromboembolism: A Metabolomic Analysis.JAHA.2018. https://www.ahajournals.org/doi/10.1161/JAHA.118.010317

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    2018-11-24 xue8602
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    2019-10-31 fusion
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    2018-11-19 zhaohui6731
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