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JCI Insight:研究揭示,2型糖尿病治疗失败的“根本”原因之一!

2017-11-21 Heather_z727 来宝网

近期,发表于《糖尿病护理》杂志上的一篇文章指出,2型糖尿病患者和体重超重的成年人大脑血糖水平的上升反应钝化。

糖尿病和肥胖患者大脑葡萄糖反应降低】近期,发表于《糖尿病护理》杂志上的一篇文章指出,2型糖尿病患者和体重超重的成年人大脑血糖水平的上升反应钝化。

众所周知,2型糖尿病的患病人数居高不下,一旦血糖控制不佳,2型糖尿病会带来一系列的可怕并发症,而近些年来,肥胖人群的数字更是与日俱增,尤其是在西方一些国家,自青少年起,肥胖就成为了威胁公共健康的一大难题。

来自耶鲁大学医学院的研究人员们进行1 h核磁共振光谱扫描,测量颅内血糖水平的变化,参与者共计25人,其中9人为健康的参与者,10人是肥胖参与者,但是没有糖尿病,其余6名为2型糖尿病患者,且血糖水平控制不佳,这六名参与者正在使用二甲双胍和胰岛素来控制血糖。

首先,研究人员将年龄,性别等风险因素进行对比,结果发现,尽管基线血糖水平和高血糖具有类似的等离子体,但是各组之间的颅内葡萄糖明显不同。与健康的参与者相比,2型糖尿病患者和肥胖参与者的大脑葡萄糖增加较低。此外,在高血糖的过程中,大脑葡萄糖的变化与血浆游离脂肪酸水平呈负相关。

来自耶鲁大学的研究人员表示:“这些数据表明,肥胖和控制不佳的2型糖尿病逐步减少了大脑葡萄糖高血糖反应,这一发现有着重要的意义,因为可以让人们了解改变摄食行为的重要性,从而降低2型糖尿病和肥胖人群的相关不良神经认知后果。”

原始出处:

Janice J. Hwang,1 Lihong Jiang, Muhammad Hamza,et al. Blunted rise in brain glucose levels during hyperglycemia in adults with obesity and T2DM. JCI Insight, 2017.

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    2017-11-30 hb2008ye
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    2017-11-21 执着追梦

    学习.谢谢分享

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