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Hepatology: 血清可利用维生素D的浓度与肝细胞癌的生存率有关

2020-05-11 MedSci原创 MedSci原创

游离和可生物利用的25-羟基维生素D是衡量维生素D的两种不同测量方法。目前尚不清楚游离的25OHD或可生物利用的25OHD与肝细胞癌(HCC)的预后是否相关。

背景和目标: 游离和可生物利用的25-羟基维生素D是衡量维生素D的两种不同测量方法。目前尚不清楚游离的25OHD或可生物利用的25OHD与肝细胞癌(HCC)的预后是否相关。本项研究的目的是检验以下假设:在与HCC生存有关的情况下,生物可利用的25OHD可能比总25OHD更好地是维生素D状态的血清生物标志物。

方法: 本项研究纳入了2013年9月至2017年4月在广东省肝癌队列中新诊断,先前未治疗过的1031例HCC患者。采用电化学发光免疫测定法测量血清总25OHD水平。使用两步酶联免疫吸附测定法测量无血清25OHD水平。使用先前验证的方程式,由测得的游离25OHD和白蛋白计算出生物可利用的25OHD水平。主要结果是肝癌特异性(LCSS)和总生存期(OS)。进行Cox比例风险模型以计算多变量风险比(HRs)和95%置信区间(CIs)。

结果: 在平均726天的随访中,有430例患者死亡,包括393例因HCC死亡。在多变量分析中,较高的25OHD生物利用度水平与更好的生存率显着相关,而与非临床和临床预后因素(包括血清C反应蛋白,巴塞罗那临床肝癌分期和癌症治疗)无关。在生物利用度25OHD水平的最高四分位数与最低四分位数之间经过多变量调整的HR为0.69(95%CI:0.51,0.93;P = 0.014 ),OS的HR为0.71(95%CI:0.53,0.94; P = 0.013)。

结论: 可利用25OHD含量较高与人群的HCC队列中的生存改善独立相关,表明25OHD的生物利用度在HCC预后中具有潜在用途。

原始出处:

Ai‐Ping Fang. Et al. Serum Bioavailable, Rather Than Total, 25‐hydroxyvitamin D Levels Are Associated With Hepatocellular Carcinoma Survival. Hepatology. 2020.

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    2021-01-16 xjy02
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    2020-07-03 mswert122

    #维生素D#与肝癌生存相关

    0

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    2020-05-13 gwc384
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