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JAMA Oncol：为预防乳腺癌，女性保持体重很重要！

2015-08-16 MedSci译 MedSci原创

乳腺癌体重
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    超过三分之二的美国女性超重或肥胖，这增加了她们绝经后患乳腺癌的风险。在女性健康倡议（WHI）临床试验延长随访后，这个二次分析调查了超重和肥胖与绝经后浸润性乳腺癌的风险的关联。    WHI的临床试验方案引入测量身高，体重，基线，一年或二年的乳房X光检查，并判定乳腺癌终点，该研究共包括了美国40个临床中心的67142例50岁至79岁的绝经后女性。这些女

超过三分之二的美国女性超重或肥胖，这增加了她们绝经后患乳腺癌的风险。在女性健康倡议（WHI）临床试验延长随访后，这个二次分析调查了超重和肥胖与绝经后浸润性乳腺癌的风险关系。


WHI的临床试验方案引入测量身高，体重，基线，一年或两年的乳房X光检查，并判定乳腺癌终点，该研究共包括了美国40个临床中心的67142例50岁至79岁的绝经后女性。这些女性从1993年到1998年被纳入此研究中，随访至2010年的中位随访时间为13年；研究人员对3388离浸润性乳腺癌病例进行了观察。


研究人员对参与者的基线测量了身高和体重，并且此后每年随访体重。关于人口特征，个人和家族病史，以及个人习惯（吸烟，体力活动）的数据进行了收集。这些女性接受了1年或2年乳房X光检查。乳腺癌是由医生评判审查病历进行核实的。


与正常体重女性相比，超重和肥胖的女性的浸润性乳腺癌的风险增加。2级加3的肥胖（身体质量指数[BMI]，由千克体重除以身高的平方计算得到，>35.0）（浸润性乳腺癌危险比（HR），1.58；95％Cl，1.40-1.79）风险最大。BMI为35.0或更高与雌激素受体阳性和孕激素受体阳性的乳腺癌风险紧密相关（HR，1.86；95％Cl，1.60-2.17），但不与雌激素受体阴性肿瘤相关。2级加3肥胖疾病进展相关，包括肿瘤体积较大（HR，2.12；95% Cl，1.67-2.69；P = 0.02），淋巴结阳性（HR，1.89；95％Cl，1.46-2.45；P=0.06），区域和/或远处的阶段（HR，1.94；95％Cl，1.52-2.47；P=0.05），以及乳腺癌后死亡（HR，2.11；95％Cl，1.57-2.84；P<0.001）。基线时BMI小于25.0的女性在随访期间体重增加超过5％的人增加患乳腺癌的风险（HR，1.36；95％Cl，1.1-1.65），但已经超重或肥胖的女性，在随访期间研究人员发现体重变化（增加或减少）与乳腺癌没有任何关联。通过绝经后激治疗对于BMI-乳腺癌的关系没有任何影响，对于从不，过去和当前使用激素治疗人群，跨BMI类别联系的方向是相似的。

肥胖增加了绝经后女性浸润性乳腺癌的风险。这些研究结果的临床意义是应该激励预防肥胖的计划。


原始出处：

Marian L. Neuhouser,Aaron K. Aragaki,Ross L. Prentice, et al.Overweight, Obesity, and Postmenopausal Invasive Breast Cancer Risk,JAMA Oncology,2015.8.11

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1864686, encodeId=577b1864686f0, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Wed May 25 11:36:00 CST 2016, time=2016-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35843, encodeId=b61235843ff, content=有没有亚洲的数据？, beContent=null, objectType=article, channel=null, level=null, likeNumber=185, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=42fa1608766, createdName=silverscalpel, createdTime=Wed Aug 19 15:35:00 CST 2015, time=2015-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35745, encodeId=0c5735e45a1, content=控制体重对心脑血管，糖尿病，肿瘤的预防都有很重要的作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=187, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=11fc1635944, createdName=DocterSunshine, createdTime=Mon Aug 17 18:40:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35730, encodeId=0b0435e3025, content=肥胖很可怕, beContent=null, objectType=article, channel=null, level=null, likeNumber=162, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Mon Aug 17 12:19:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35706, encodeId=541235e0681, content=预防肥胖, beContent=null, objectType=article, channel=null, level=null, likeNumber=193, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66c61628089, createdName=caierhong, createdTime=Mon Aug 17 09:15:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35704, encodeId=d15635e0404, content=减肥, beContent=null, objectType=article, channel=null, level=null, likeNumber=186, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/11/79b7aa038ec52a741938a0243c9023e4.jpg, createdBy=7cf41618060, createdName=zhangshi908, createdTime=Mon Aug 17 06:45:00 CST 2015, time=2015-08-17, status=1, ipAttribution=)]
    2016-05-25 minlingfeng

    #Oncol#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1864686, encodeId=577b1864686f0, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Wed May 25 11:36:00 CST 2016, time=2016-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35843, encodeId=b61235843ff, content=有没有亚洲的数据？, beContent=null, objectType=article, channel=null, level=null, likeNumber=185, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=42fa1608766, createdName=silverscalpel, createdTime=Wed Aug 19 15:35:00 CST 2015, time=2015-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35745, encodeId=0c5735e45a1, content=控制体重对心脑血管，糖尿病，肿瘤的预防都有很重要的作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=187, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=11fc1635944, createdName=DocterSunshine, createdTime=Mon Aug 17 18:40:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35730, encodeId=0b0435e3025, content=肥胖很可怕, beContent=null, objectType=article, channel=null, level=null, likeNumber=162, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Mon Aug 17 12:19:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35706, encodeId=541235e0681, content=预防肥胖, beContent=null, objectType=article, channel=null, level=null, likeNumber=193, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66c61628089, createdName=caierhong, createdTime=Mon Aug 17 09:15:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35704, encodeId=d15635e0404, content=减肥, beContent=null, objectType=article, channel=null, level=null, likeNumber=186, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/11/79b7aa038ec52a741938a0243c9023e4.jpg, createdBy=7cf41618060, createdName=zhangshi908, createdTime=Mon Aug 17 06:45:00 CST 2015, time=2015-08-17, status=1, ipAttribution=)]
    2015-08-19 silverscalpel

    有没有亚洲的数据？

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1864686, encodeId=577b1864686f0, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Wed May 25 11:36:00 CST 2016, time=2016-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35843, encodeId=b61235843ff, content=有没有亚洲的数据？, beContent=null, objectType=article, channel=null, level=null, likeNumber=185, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=42fa1608766, createdName=silverscalpel, createdTime=Wed Aug 19 15:35:00 CST 2015, time=2015-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35745, encodeId=0c5735e45a1, content=控制体重对心脑血管，糖尿病，肿瘤的预防都有很重要的作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=187, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=11fc1635944, createdName=DocterSunshine, createdTime=Mon Aug 17 18:40:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35730, encodeId=0b0435e3025, content=肥胖很可怕, beContent=null, objectType=article, channel=null, level=null, likeNumber=162, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Mon Aug 17 12:19:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35706, encodeId=541235e0681, content=预防肥胖, beContent=null, objectType=article, channel=null, level=null, likeNumber=193, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66c61628089, createdName=caierhong, createdTime=Mon Aug 17 09:15:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35704, encodeId=d15635e0404, content=减肥, beContent=null, objectType=article, channel=null, level=null, likeNumber=186, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/11/79b7aa038ec52a741938a0243c9023e4.jpg, createdBy=7cf41618060, createdName=zhangshi908, createdTime=Mon Aug 17 06:45:00 CST 2015, time=2015-08-17, status=1, ipAttribution=)]
    2015-08-17 DocterSunshine

    控制体重对心脑血管，糖尿病，肿瘤的预防都有很重要的作用

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1864686, encodeId=577b1864686f0, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Wed May 25 11:36:00 CST 2016, time=2016-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35843, encodeId=b61235843ff, content=有没有亚洲的数据？, beContent=null, objectType=article, channel=null, level=null, likeNumber=185, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=42fa1608766, createdName=silverscalpel, createdTime=Wed Aug 19 15:35:00 CST 2015, time=2015-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35745, encodeId=0c5735e45a1, content=控制体重对心脑血管，糖尿病，肿瘤的预防都有很重要的作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=187, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=11fc1635944, createdName=DocterSunshine, createdTime=Mon Aug 17 18:40:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35730, encodeId=0b0435e3025, content=肥胖很可怕, beContent=null, objectType=article, channel=null, level=null, likeNumber=162, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Mon Aug 17 12:19:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35706, encodeId=541235e0681, content=预防肥胖, beContent=null, objectType=article, channel=null, level=null, likeNumber=193, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66c61628089, createdName=caierhong, createdTime=Mon Aug 17 09:15:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35704, encodeId=d15635e0404, content=减肥, beContent=null, objectType=article, channel=null, level=null, likeNumber=186, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/11/79b7aa038ec52a741938a0243c9023e4.jpg, createdBy=7cf41618060, createdName=zhangshi908, createdTime=Mon Aug 17 06:45:00 CST 2015, time=2015-08-17, status=1, ipAttribution=)]
    2015-08-17 stupidox

    肥胖很可怕

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1864686, encodeId=577b1864686f0, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Wed May 25 11:36:00 CST 2016, time=2016-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35843, encodeId=b61235843ff, content=有没有亚洲的数据？, beContent=null, objectType=article, channel=null, level=null, likeNumber=185, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=42fa1608766, createdName=silverscalpel, createdTime=Wed Aug 19 15:35:00 CST 2015, time=2015-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35745, encodeId=0c5735e45a1, content=控制体重对心脑血管，糖尿病，肿瘤的预防都有很重要的作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=187, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=11fc1635944, createdName=DocterSunshine, createdTime=Mon Aug 17 18:40:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35730, encodeId=0b0435e3025, content=肥胖很可怕, beContent=null, objectType=article, channel=null, level=null, likeNumber=162, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Mon Aug 17 12:19:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35706, encodeId=541235e0681, content=预防肥胖, beContent=null, objectType=article, channel=null, level=null, likeNumber=193, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66c61628089, createdName=caierhong, createdTime=Mon Aug 17 09:15:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35704, encodeId=d15635e0404, content=减肥, beContent=null, objectType=article, channel=null, level=null, likeNumber=186, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/11/79b7aa038ec52a741938a0243c9023e4.jpg, createdBy=7cf41618060, createdName=zhangshi908, createdTime=Mon Aug 17 06:45:00 CST 2015, time=2015-08-17, status=1, ipAttribution=)]
    2015-08-17 caierhong

    预防肥胖

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1864686, encodeId=577b1864686f0, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Wed May 25 11:36:00 CST 2016, time=2016-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35843, encodeId=b61235843ff, content=有没有亚洲的数据？, beContent=null, objectType=article, channel=null, level=null, likeNumber=185, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=42fa1608766, createdName=silverscalpel, createdTime=Wed Aug 19 15:35:00 CST 2015, time=2015-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35745, encodeId=0c5735e45a1, content=控制体重对心脑血管，糖尿病，肿瘤的预防都有很重要的作用, beContent=null, objectType=article, channel=null, level=null, likeNumber=187, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=11fc1635944, createdName=DocterSunshine, createdTime=Mon Aug 17 18:40:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35730, encodeId=0b0435e3025, content=肥胖很可怕, beContent=null, objectType=article, channel=null, level=null, likeNumber=162, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Mon Aug 17 12:19:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35706, encodeId=541235e0681, content=预防肥胖, beContent=null, objectType=article, channel=null, level=null, likeNumber=193, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66c61628089, createdName=caierhong, createdTime=Mon Aug 17 09:15:00 CST 2015, time=2015-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=35704, encodeId=d15635e0404, content=减肥, beContent=null, objectType=article, channel=null, level=null, likeNumber=186, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/11/79b7aa038ec52a741938a0243c9023e4.jpg, createdBy=7cf41618060, createdName=zhangshi908, createdTime=Mon Aug 17 06:45:00 CST 2015, time=2015-08-17, status=1, ipAttribution=)]
    2015-08-17 zhangshi908

    减肥

    0

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Cedars-Sinai的研究人员发现了一种新的可在许多乳腺癌和前列腺癌发展过程中起作用的遗传标志物。这一发现将有助于临床医生更好的识别对侵袭性癌症的化疗药物有反应的患者。该研究结果发表于《科学报告》杂志中。“理解和识别生物学标志物是癌症研究和护理过程中中至关重要的一步，”该研究第一作者，Cedars-Sinai外科病研究副主席Michael Freeman博士说道，“以这项研究为例的新的分析策略

JNCI：预测乳腺癌患者的预后的新方法

背景：以往研究表明，对HER2的胞内结构域（ICD）和胞外结构域（ECD）使用传统治疗方法的抗体疗效是一样的。本研究采取了一个新的方法来分别定量ICD和ECD的表达，以评估接受曲妥珠单抗辅助治疗的患者的HER2特定结构域的预测价值。 方法：研究人员通过在组织芯片上使用两种抗体--抗ICD抗体（CB11 和A0485）和抗ECD抗体（SP3和D8F12），再通过定量免疫荧光技术（QIF）来检测HE

Breast Cancer Res：乳腺癌新型生物标志物及治疗靶点

一篇发表于国际杂志Breast Cancer Research上的研究报告中，来自波士顿大学医学院的研究者开发出了一种新型方法，其或许可以帮助检测/治疗恶性乳腺癌。 基底细胞样型乳腺癌 (Basal-like breast cancer，BLBC)是一种恶性乳腺癌，其通常被成为三阴性乳腺癌，这就意味着这种恶性乳腺癌对于常见的医疗手段并没有任何反应；基底细胞样型乳腺癌更容易发生转移，快速且容

Oncogene：昆明动物所揭示KLF5转录因子在乳腺癌中的功能和机制

转移是导致乳腺癌患者死亡的主要原因，因此防治转移是乳腺癌研究的关键。而在乳腺癌中，基底型ER/PR/HER2三阴性乳腺癌恶性程度最高，具有较高的侵袭性，术后复发转移风险高，疾病进展快，目前还没有找到有效的药物治疗靶标，是乳腺癌治疗的瓶颈和研究的热点。中国科学院昆明动物研究所研究员陈策实领导的肿瘤生物学实验室通过多年研究证实KLF5在三阴性乳腺癌中高表达，是三阴性乳腺癌一个潜在治疗靶点。然而，KLF

JCO：不同亚型乳腺癌，使用来曲唑效果不同

浸润性小叶癌（ILC）是第二常见的乳腺癌亚型，大约有10%的乳腺癌是这一亚型。ILC在流行病学、临床病理学特征以及对全身性治疗的响应不同于最常见的亚型浸润性导管癌（IDC）。回顾性研究表明早期ILC对于化疗的响应差于IDC。比较ILC和IDC激素疗法的有效性的资料较少。目前仍不清楚不同的疗法对于不同的亚型是不是有差异。为了评估来曲唑用于IDC或ILC相对于他莫西芬的相对效力。研究人员进行了临床试验

Cell Report：阻断氧气传感分子PHD2可抑制乳腺癌的转移

比利时鲁汶大学研究人员发现，降低氧气传感分子PHD2的表达可削弱乳腺癌转移（扩散）到身体其他部位的能力。乳腺癌是女性癌症死亡的第二大死因，主要死于癌细胞的转移。这些表明，抑制PHD2可能在治疗乳腺癌方面具有潜在的价值。该研究成果发表于 Cell Reports。本研究首次检测了自发性乳腺癌模型（相比于以往的移植性肿瘤与人类癌症更相似）中阻断PHD2表达的作用。该研究还发现了基质成纤维细胞（支持并

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