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PNAS:过长时间暴露于光线下可导致体重增加!!

2015-05-14 佚名 生物谷

来自荷兰Leiden大学医学中心和学术医学中心的两个研究团队联合研究发现了,长时间暴露在光线下的小鼠体重增加的原因。他们发表于PNAS杂志上的文章描述了,他们是如何检测了当小鼠在长时间地暴露于不同量的光线后,这些小鼠的食物燃烧效率以及其与体重增加的关系。科学家们已知过度暴露于光线下,或者是在奇怪的时间段暴露于光线下,会引起人们的体重增加,随之而来导致一些疾病发生。但是,为什么会是这样的,现在仍不清

来自荷兰Leiden大学医学中心和学术医学中心的两个研究团队联合研究发现了,长时间暴露在光线下的小鼠体重增加的原因。他们发表于PNAS杂志上的文章描述了,他们是如何检测了当小鼠在长时间地暴露于不同量的光线后,这些小鼠的食物燃烧效率以及其与体重增加的关系。

科学家们已知过度暴露于光线下,或者是在奇怪的时间段暴露于光线下,会引起人们的体重增加,随之而来导致一些疾病发生。但是,为什么会是这样的,现在仍不清 楚。许多人们,尤其是那些上夜班的人们,他们认为他们的体重增加是因为,长时间的工作及不规律的日程安排引起的增长的压力导致的。在这项新的研究工作中, 看起来这些人可能是对的,但并不是他们所认为的那样。

为了研究清楚人们(或是在此研究中的小鼠)为什么在每天长时间地暴露于光线下,会引起体重增加,研究团队将小鼠饲养在日/夜交替可改变的环境里-不同的小组生活在人造光源下12,16和24小时,为期1个月。研究人员们猜测棕色脂肪组织在此过程中起了一定的作用,所以他们监测了所有小鼠的棕色脂肪的效率。棕色脂肪在将食物转换为热量的过程中起到了重要的作用。如果食物中的能量没有被转化为热量,那么就会被储存为脂肪。

在监测棕色脂肪效率水平的时候,研究团队发现,那些暴露在长时间光线下的小鼠不仅仅是体重有所增加(尽管它们和对照组的小鼠吃相同量的食物和进行同样的运动),而且它们的棕色脂肪的效率也有所下降。因此,长时间的暴露于光线下,可以使机体储存更多的食物能量,而不是把这些能量转化为热量。研究团队提示这同样适用于人类,回到远古时代,夏天(更多的光照时间)对人们就意味着储存起脂肪,以在寒冷的冬季御寒。


原始出处:


Sander Kooijmana, Rosa van den Berga, Ashna Ramkisoensingc, Mariëtte R. Boona,b, Eline N. Kuipersa, Marieke Loefa, Tom C. M. Zonnevelda, Eliane A. Lucassenc, Hetty C. M. Sipsa, Iliana A. Chatzispyroud, Riekelt H. Houtkooperd, Johanna H. Meijerc, Claudia P. Coomansc, Nienke R. Biermasza, and Patrick C. N. Rensena.Prolonged daily light exposure increases body fat mass through attenuation of brown adipose tissue activity.PNAS, May 11, 2015.doi: 10.1073/pnas.1504239112 

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    2015-09-06 drwjr
  2. [GetPortalCommentsPageByObjectIdResponse(id=1855730, encodeId=455e1855e3060, content=<a href='/topic/show?id=f32014428fc' target=_blank style='color:#2F92EE;'>#PNAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14428, encryptionId=f32014428fc, topicName=PNAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e964, createdName=drwjr, createdTime=Sun Sep 06 14:51:00 CST 2015, time=2015-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23916, encodeId=4446239166f, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Sun May 17 20:07:00 CST 2015, time=2015-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23808, encodeId=0d0323808de, content=减肥思路啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJUNfdk68bHutYruGyxbKDzPWH3agcmId19Yf94FiapyicN0LTg0jykhqIhjPQVdR08FGR399rBpZIg/132, createdBy=feae1624323, createdName=Dr.LV, createdTime=Sun May 17 07:43:00 CST 2015, time=2015-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1298193, encodeId=6b55129819353, content=<a href='/topic/show?id=3379266918f' target=_blank style='color:#2F92EE;'>#体重增加#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26691, encryptionId=3379266918f, topicName=体重增加)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45b2276, createdName=839640778, createdTime=Sat May 16 05:51:00 CST 2015, time=2015-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23572, encodeId=4f86235e295, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3yz0JbjHQ7nicJU7lHMOu0Itf3Zv3VBzEvK3k4AFPBXhiaxIRNGVI33GicoRXQEjkaasjdlWKwZuwcyhDP9Jibqt5ct/0, createdBy=f1281613275, createdName=zhouanxiu, createdTime=Fri May 15 07:42:00 CST 2015, time=2015-05-15, status=1, ipAttribution=)]
    2015-05-17 huaxipanxing

    看看

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1855730, encodeId=455e1855e3060, content=<a href='/topic/show?id=f32014428fc' target=_blank style='color:#2F92EE;'>#PNAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14428, encryptionId=f32014428fc, topicName=PNAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e964, createdName=drwjr, createdTime=Sun Sep 06 14:51:00 CST 2015, time=2015-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23916, encodeId=4446239166f, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Sun May 17 20:07:00 CST 2015, time=2015-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23808, encodeId=0d0323808de, content=减肥思路啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJUNfdk68bHutYruGyxbKDzPWH3agcmId19Yf94FiapyicN0LTg0jykhqIhjPQVdR08FGR399rBpZIg/132, createdBy=feae1624323, createdName=Dr.LV, createdTime=Sun May 17 07:43:00 CST 2015, time=2015-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1298193, encodeId=6b55129819353, content=<a href='/topic/show?id=3379266918f' target=_blank style='color:#2F92EE;'>#体重增加#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26691, encryptionId=3379266918f, topicName=体重增加)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45b2276, createdName=839640778, createdTime=Sat May 16 05:51:00 CST 2015, time=2015-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23572, encodeId=4f86235e295, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3yz0JbjHQ7nicJU7lHMOu0Itf3Zv3VBzEvK3k4AFPBXhiaxIRNGVI33GicoRXQEjkaasjdlWKwZuwcyhDP9Jibqt5ct/0, createdBy=f1281613275, createdName=zhouanxiu, createdTime=Fri May 15 07:42:00 CST 2015, time=2015-05-15, status=1, ipAttribution=)]
    2015-05-17 Dr.LV

    减肥思路啊

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1855730, encodeId=455e1855e3060, content=<a href='/topic/show?id=f32014428fc' target=_blank style='color:#2F92EE;'>#PNAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14428, encryptionId=f32014428fc, topicName=PNAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e964, createdName=drwjr, createdTime=Sun Sep 06 14:51:00 CST 2015, time=2015-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23916, encodeId=4446239166f, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Sun May 17 20:07:00 CST 2015, time=2015-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23808, encodeId=0d0323808de, content=减肥思路啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJUNfdk68bHutYruGyxbKDzPWH3agcmId19Yf94FiapyicN0LTg0jykhqIhjPQVdR08FGR399rBpZIg/132, createdBy=feae1624323, createdName=Dr.LV, createdTime=Sun May 17 07:43:00 CST 2015, time=2015-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1298193, encodeId=6b55129819353, content=<a href='/topic/show?id=3379266918f' target=_blank style='color:#2F92EE;'>#体重增加#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26691, encryptionId=3379266918f, topicName=体重增加)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45b2276, createdName=839640778, createdTime=Sat May 16 05:51:00 CST 2015, time=2015-05-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23572, encodeId=4f86235e295, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3yz0JbjHQ7nicJU7lHMOu0Itf3Zv3VBzEvK3k4AFPBXhiaxIRNGVI33GicoRXQEjkaasjdlWKwZuwcyhDP9Jibqt5ct/0, createdBy=f1281613275, createdName=zhouanxiu, createdTime=Fri May 15 07:42:00 CST 2015, time=2015-05-15, status=1, ipAttribution=)]
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    2015-05-15 zhouanxiu

    有意思

    0

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中年时体重过低可增加晚年发生痴呆的风险,而超重或肥胖可防止痴呆的发生。近期,The Lancet Diabetes & Endocrinology上报道了一项关于BMI与痴呆风险的大型研究。 本文作者Nawab Qizilbashsh,来自英国London School of Hygiene and Tropical Medicine ,说道:“我们的研究结果与以往许多的研究结果

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