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Hypertension:暴露于空气污染会导致高血压风险的增加,无论是长期还是短期

2016-06-03 Seven L 译 MedSci原创

近期发表在hypertension的系统回顾和荟萃分析结果表明,短期和长期暴露于颗粒物和其他环境空气污染物与高血压风险增加显著相关。“空气污染的短期和长期影响可能有非互斥的生物学机制,即对交感神经系统的氧化应激、内皮、血流动力学功能和血管张力等产生直接和间接影响。”中国广东省公共卫生研究所副所长和环境卫生部门流行病学家Tao Liu说,“了解空气污染的短期和长期效果之间的差异可以为政策制定者和高血

近期发表在Hypertension上的系统回顾和荟萃分析结果表明,短期和长期暴露于颗粒物和其他环境空气污染物与高血压风险增加显著相关。


“空气污染的短期和长期影响可能有非互斥的生物学机制,即对交感神经系统的氧化应激、内皮、血流动力学功能和血管张力等产生直接和间接影响。”中国广东省公共卫生研究所副所长和环境卫生部门流行病学家Tao Liu说,“了解空气污染的短期和长期效果之间的差异可以为政策制定者和高血压的临床防治提供进一步的信息。”

从20世纪90年代以来,在空气污染和高血压之间的联系已经进行了一些研究,但是,结果是有争议的。研究人员对17个相关的研究进行评估,,共涉及超过108000名高血压患者和220000名对照者,其中6项提到短期影响、11项提到长期影响。暴露在空气中的污染物包括一氧化碳(CO)、氮氧化物(NO2和NOx)、臭氧(O3)、可吸入颗粒物((PM2.5和PM10)和二氧化硫(SO2)。

研究结果表明,短期暴露于SO2、PM2.5和PM10与高血压的发展显著相关(OR分别为:OR = 1.046; 95% CI, 1.012-1.081; OR = 1.069; 95% CI, 1.003-1.141; OR = 1.024; 95% CI, 1.016-1.032)。短期风险研究分别有2项、2项、1项和1项在中国、加拿大、巴西和伊朗进行。

长期暴露于NO2和PM10,与高血压发生风险显著相关(OR分别为:OR = 1.034; 95% CI, 1.005-1.063; OR = 1.054; 95% CI, 1.036-1.072)。长期研究中有3项在中国进行,2项在美国,2项瑞典,还有4项分别在加拿大、丹麦、德国和西班牙。

虽然这项荟萃分析说明了空气污染暴露和高血压之间的关联,但仍需要进一步的数据。

“我们的研究结果对公共卫生是十分重要的,因为空气污染和高血压是重要的全球公共健康问题,” Liu说,“尽管空气污染暴露与较小的高血压风险有关,但由于空气污染的普遍存在,它可能会带来一个巨大人口比例的高血压疾病负担。因此,如果这些风险是可以避免的,将从理论上降低高血压的发病率。”

原始出处:

Cai Y, et al.Associations  of  Short-Term  and  Long-Term  Exposure to Ambient Air Pollutants With Hypertension.Hypertension. 2016;doi:10.1161/HYPERTENSIONAHA.116.07218.

Both short, long-term exposure to air pollutants linked to hypertension risk.Healio.June 2, 2016

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  2. [GetPortalCommentsPageByObjectIdResponse(id=2038540, encodeId=5d49203854085, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Fri Jan 20 00:12:00 CST 2017, time=2017-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=122342, encodeId=8bce1223429a, content=己拜读,受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Sep 11 10:02:00 CST 2016, time=2016-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726118, encodeId=0cd21e26118a0, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Feb 05 23:12:00 CST 2017, time=2017-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93005, encodeId=461793005eb, content=在这空气污染的城市里,也是受够了, beContent=null, objectType=article, channel=null, level=null, likeNumber=154, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Wed Jul 13 20:25:00 CST 2016, time=2016-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91785, encodeId=ccc691e85e9, content=我相信这是真的,这可以解释高血压人群越来越多, beContent=null, objectType=article, channel=null, level=null, likeNumber=198, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9ebb1716792, createdName=黑心天使, createdTime=Sat Jul 02 17:34:00 CST 2016, time=2016-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472504, encodeId=a30314e25042b, content=<a href='/topic/show?id=ba4a6436107' target=_blank style='color:#2F92EE;'>#污染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64361, encryptionId=ba4a6436107, topicName=污染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dfe67217539, createdName=小刀医生, createdTime=Sun Jun 05 10:12:00 CST 2016, time=2016-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501076, encodeId=745115010e618, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Sun Jun 05 10:12:00 CST 2016, time=2016-06-05, status=1, ipAttribution=)]
    2016-09-11 1e10c84am36(暂无匿称)

    己拜读,受益匪浅

    0

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    2017-02-05 feather89
  4. [GetPortalCommentsPageByObjectIdResponse(id=2038540, encodeId=5d49203854085, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Fri Jan 20 00:12:00 CST 2017, time=2017-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=122342, encodeId=8bce1223429a, content=己拜读,受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Sep 11 10:02:00 CST 2016, time=2016-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726118, encodeId=0cd21e26118a0, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Feb 05 23:12:00 CST 2017, time=2017-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93005, encodeId=461793005eb, content=在这空气污染的城市里,也是受够了, beContent=null, objectType=article, channel=null, level=null, likeNumber=154, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Wed Jul 13 20:25:00 CST 2016, time=2016-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91785, encodeId=ccc691e85e9, content=我相信这是真的,这可以解释高血压人群越来越多, beContent=null, objectType=article, channel=null, level=null, likeNumber=198, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9ebb1716792, createdName=黑心天使, createdTime=Sat Jul 02 17:34:00 CST 2016, time=2016-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472504, encodeId=a30314e25042b, content=<a href='/topic/show?id=ba4a6436107' target=_blank style='color:#2F92EE;'>#污染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64361, encryptionId=ba4a6436107, topicName=污染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dfe67217539, createdName=小刀医生, createdTime=Sun Jun 05 10:12:00 CST 2016, time=2016-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501076, encodeId=745115010e618, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Sun Jun 05 10:12:00 CST 2016, time=2016-06-05, status=1, ipAttribution=)]
    2016-07-13 oo902

    在这空气污染的城市里,也是受够了

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2038540, encodeId=5d49203854085, content=<a href='/topic/show?id=b45d1e274e8' target=_blank style='color:#2F92EE;'>#TENS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17274, encryptionId=b45d1e274e8, topicName=TENS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3b172500206, createdName=12498ebem19暂无昵称, createdTime=Fri Jan 20 00:12:00 CST 2017, time=2017-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=122342, encodeId=8bce1223429a, content=己拜读,受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Sep 11 10:02:00 CST 2016, time=2016-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1726118, encodeId=0cd21e26118a0, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Feb 05 23:12:00 CST 2017, time=2017-02-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93005, encodeId=461793005eb, content=在这空气污染的城市里,也是受够了, beContent=null, objectType=article, channel=null, level=null, likeNumber=154, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Wed Jul 13 20:25:00 CST 2016, time=2016-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=91785, encodeId=ccc691e85e9, content=我相信这是真的,这可以解释高血压人群越来越多, beContent=null, objectType=article, channel=null, level=null, likeNumber=198, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9ebb1716792, createdName=黑心天使, createdTime=Sat Jul 02 17:34:00 CST 2016, time=2016-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472504, encodeId=a30314e25042b, content=<a href='/topic/show?id=ba4a6436107' target=_blank style='color:#2F92EE;'>#污染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64361, encryptionId=ba4a6436107, topicName=污染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dfe67217539, createdName=小刀医生, createdTime=Sun Jun 05 10:12:00 CST 2016, time=2016-06-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1501076, encodeId=745115010e618, content=<a href='/topic/show?id=f2db9238f9' target=_blank style='color:#2F92EE;'>#Hypertension#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9238, encryptionId=f2db9238f9, topicName=Hypertension)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11ff9497046, createdName=jambiya, createdTime=Sun Jun 05 10:12:00 CST 2016, time=2016-06-05, status=1, ipAttribution=)]
    2016-07-02 黑心天使

    我相信这是真的,这可以解释高血压人群越来越多

    0

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