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Hum Pathol:胃泌素释放肽或表达示乳腺癌预后不良

2012-08-03 朱金 医学论坛网

  我国学者近期发表于《人体病理学》(Hum Pathol)杂志的一项研究表明,胃泌素释放肽的表达可能与乳腺癌淋巴结转移相关,并可能可用作乳腺癌患者预后不良的一个预测指标。   胃泌素释放肽是一种未折叠的蛋白反应调节肽,在内质网中作为Ca2+结合分子伴侣发挥功能,它是一种人源性调节性肽,具有诱发胃泌素释放及调节胃酸分泌和肠道运动的功能。研究已证明它在小细胞肺癌中有促有丝分裂的活性,并在

  我国学者近期发表于《人体病理学》(Hum Pathol)杂志的一项研究表明,胃泌素释放肽的表达可能与乳腺癌淋巴结转移相关,并可能可用作乳腺癌患者预后不良的一个预测指标。

  胃泌素释放肽是一种未折叠的蛋白反应调节肽,在内质网中作为Ca2+结合分子伴侣发挥功能,它是一种人源性调节性肽,具有诱发胃泌素释放及调节胃酸分泌和肠道运动的功能。研究已证明它在小细胞肺癌中有促有丝分裂的活性,并在很多其他包括结肠、胃、胰腺、乳腺和前列腺肿瘤的人类癌症发病中发挥作用。这项研究调查了胃泌素释放肽在乳腺癌中的表达,以证明它在乳腺癌转移中有生物标志物的作用。

  该研究用免疫组化法在乳腺肿瘤组织芯片标本中分析胃泌素释放肽,样本包括200例原发性乳腺癌肿瘤标本和与之相应的相同患者的淋巴结。研究用transwell分析方法评估胃泌素释放肽对MCF-7细胞的侵袭能力的影响。

  结果显示,胃泌素释放肽在淋巴结转移的乳腺癌患者中高度表达。此外,在淋巴结转移的患者中,那些胃泌素释放肽表达水平较高的患者生存时间较短。胃泌素释放肽过度表达显著增强细胞的侵袭性。相反,用短发夹RNA敲除胃泌素释放肽显著减弱MCF-7细胞的侵袭性。

  相关链接:Ni C,Zhao X,Sun T, Liu Y,Gu Q, Sun B.Role of gastrin-releasing peptids in breast cancer metastasis.Hum Pathol.2012 Jul 10



    

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