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盘点:一文了解益生菌如何“益生”

2016-08-06 MedSci MedSci原创

益生菌是一类对宿主有益的活性微生物,是定植于人体肠道、生殖系统内,既往较多研究表明益生菌有益于机体的多种健康,现在小编就这些研究做一总结与大家分享。 【1】 有助于控制血糖 发表于Diabetes Res Clin Pract的一项系统回顾和荟萃分析评价了益生菌对2型糖尿病(T2DM)干预的研究,并分析益生菌对T2DM患者血糖控制的影响。 研究最终纳入五项研究进行分析,发现当

益生菌是一类对宿主有益的活性微生物,是定植于人体肠道、生殖系统内,既往较多研究表明益生菌有益于机体的多种健康,现在小编就这些研究做一总结与大家分享。

【1】 有助于控制血糖

发表于Diabetes Res Clin Pract的一项系统回顾和荟萃分析评价了益生菌对2型糖尿病(T2DM)干预的研究,并分析益生菌对T2DM患者血糖控制的影响。

研究最终纳入五项研究进行分析,发现当与安慰剂组相比时,益生菌治疗组的FBG明显降低,异质性中等程度但并不明显。HbA1c和其他次要结果的组间差异较小。

总而言之,益生菌具有中等程度的降血糖作用,可明显降低FBG。但是,益生菌对于HbA1c、抗炎和抗氧化作用却并不一致。(文章详见——Diabetes Res Clin Pract:益生菌可显著降低2型糖尿病患者的空腹血糖)

此外,美国Cornell University发表于Diabetes上的一项研究表明,大鼠服用改造过的表达GLP-1的乳酸杆菌,可显著控制机体的血糖。

研究人员将含有GLP-1(1-37)的载体转入人乳酸杆菌,然后每天为糖尿病大鼠口服这种益生菌片。结果发现,大鼠服用后,胰岛素分泌量和对血糖耐受能力明显增加;小肠上段出现许多胰岛素分泌细胞,数量相当于正常大鼠胰岛B细胞的25~33%;并且这些新胰岛素分泌细胞内检测到胰岛B细胞所特有的转录因子MafA,PDX-1,FoxA2的表达。这表示这些细胞与B细胞极其相似。

这个研究结果为将来糖尿病的治疗提供了一个既安全又有效的口服药物的选择。实际上这项技术已经获得生产许可。或许在不久将来糖尿病患者只需每天早上服用一片益生菌片,就能帮助控制血糖。(文章详见——Diabetes:糖尿病治疗这么简单?服用益生菌药片就可以降血糖)



【2】降低女性患乳腺癌的风险

加拿大安大略西部大学的研究人员通过对80名乳腺癌或健康女性的乳房组织进行研究发现,通过乳房组织中的细菌种类可评估女性患乳腺癌的风险。

他们发现,乳腺癌患者乳房组织内大肠杆菌和表皮葡萄球菌水平较高,但乳房组织若存在高浓度的乳酸杆菌和链球菌则对机体有利。这一发现证实人们之前认为摄入益生菌酸奶和牛奶等食物可降低女性罹患乳腺癌的风险。

研究纳入58名乳房组织癌变的女性,其中13名女性接受乳房肿瘤切除术或乳房肿瘤为良性肿瘤,45名女性处于恶性肿瘤进展期。结果共有23名女性恢复健康状况。研究人员认为可将益生菌作为未来癌症治疗药物,但是他们表示仍需更进一步的研究和调查以探究益生菌和乳腺癌之间的因果关系。(文章详见——Appl Environ Microbiol:补充益生菌可降低女性患乳腺癌的风险



【3】降低抗生素使用者艰难梭菌感染

根据2016消化疾病周给出的数据,益生菌可显著降低已使用抗生素的住院患者艰难梭菌感染的风险。现有证据表明,益生菌的使用大大降低了使用抗生素的住院患者艰难梭菌感染的风险,不需要进一步的研究确来立有效性。

研究人员回顾了关于使用抗生素和益生菌的住院成人患者的随机对照试验,结果发现益生菌组较安慰剂组艰难梭菌感染率小。总的来说,益生菌表现了治疗艰难梭菌感染的疗效。在指定亚组分析中,首次抗生素剂量有关的益生菌时间安排是很重要的,在2天和7天内给予益生菌的RR分别为0.32和0.70。(文章详见——【DDW 2016】益生菌降低抗生素使用者艰难梭菌感染



【4】或可用于牙周疾病的预防和治疗

据发表于Journal of dentistry的一项新的荟萃分析发现,益生菌疗法可用于牙周疾病的治疗,但是对于龋齿,则需进一步的研究以确定其疗效和安全性。

研究共纳入了50项研究(3247名参与者)符合条件的研究,分析发现益生菌可显著增加SM或LB的数目降低到104 CFU/mL以下的几率。对于牙周致病菌,其数目的变化并不显著。益生菌可显著降低探针出血指数和牙龈指数,但是并不会明显降低菌斑指数。还可明显降低牙周袋探诊深度。

从本研究的结果来看,目前的证据尚不足以推荐益生菌用于龋齿的管理,但支持使用益生菌用于牙龈炎或牙周炎的管理。(文章详见——J Dent:益生菌或可用于牙周疾病的预防和治疗

【5】有助于减少不良情绪

一项发表在Brain, Behavior, and Immunity上的随机对照研究表明,益生菌有助于减少人对悲伤情绪的认知反应,特别是能够减少人的沉思和攻击性。

一项来自新西兰的研究表明,含有双歧杆菌W23,乳双歧杆菌W52,嗜酸乳杆菌W37,短乳杆菌W63,干酪乳杆菌W56,唾液乳杆菌W24和乳酸乳球菌(W19和W58)等多种益生菌的复合物能够减少非抑郁患者的认知反应。

该研究共招募了40个年轻志愿者,干预前和4周后评估其情绪状态。结果发现,接受益生菌干预的组,对悲伤情绪的整体反应明显下降,特别是沉思和攻击性明显降低。

总而言之,该研究首次表明,摄入益生菌可能有助于减少与悲伤情绪有关的消极情绪。益生菌补充剂可以作为一种预防精神疾病的有效方法。(文章详见——Brain Behav Immun:益生菌有助于减少不良情绪

【6】有助于控制血压

早前就有临床试验证明益生菌有利于高血压的控制,该荟萃分析研究再次显示,摄入益生菌可在一定程度上降低血压。

研究共纳入9项临床试验的543例受试者,结果显示,益生菌组平均收缩压降低3.56 mm Hg,平均舒张压降低2.38 mm Hg。对于血压高于130/85 mm Hg的受试者,益生菌的作用最为明显,此外,补充多种益生菌的降压效果更为明显。但数据也显示,服用含益生菌的奶制品的时间低于8周,将无法起到这种效果。

这些研究结果显示出益生菌的降压作用,益生菌在未来可作为预防高血压或改善血压控制的补充治疗手段。但还需更多大型临床研究数据来确定益生菌的降压效果。(文章详见——Hypertension:益生菌酸奶有助于血压的控制




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    2016-08-08 1dee1b88m43(暂无匿称)

    讲的非常好!

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    2016-08-06 明崖

    学习了,太有用了

    0

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    2016-08-06 青荷

    学习了,继续关注

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=96867, encodeId=46d69686e65, content=讲的非常好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLF3V7KY7WyRVHCticgpdCWVsqAsLGF1UrrVc5TFS9ZI2DrEs5plCGBUaLqHXvCU4fhImjFdZ9PjiaS/0, createdBy=8f971728670, createdName=1dee1b88m43(暂无匿称), createdTime=Mon Aug 08 10:34:00 CST 2016, time=2016-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96419, encodeId=29aa9641995, content=学习了,太有用了, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Sat Aug 06 11:40:00 CST 2016, time=2016-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96352, encodeId=2692963524d, content=学习了,继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160528/IMG5749A60FD120A3124.jpg, createdBy=65fe1709307, createdName=青荷, createdTime=Sat Aug 06 09:26:00 CST 2016, time=2016-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96336, encodeId=5eca963363f, content=益生菌益生, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sat Aug 06 09:03:00 CST 2016, time=2016-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96296, encodeId=544396296b5, content=学习了,赞一个!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Sat Aug 06 08:47:00 CST 2016, time=2016-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96297, encodeId=ba099629e27, content=学习了,赞一个!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Sat Aug 06 08:47:00 CST 2016, time=2016-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96298, encodeId=bc1f96298e6, content=学习了,赞一个!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Sat Aug 06 08:47:00 CST 2016, time=2016-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96299, encodeId=65309629914, content=学习了,赞一个!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Sat Aug 06 08:47:00 CST 2016, time=2016-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96289, encodeId=57ac9628920, content=分人群吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Sat Aug 06 08:32:00 CST 2016, time=2016-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96275, encodeId=0112962e553, content=stop, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1b2c1297487, createdName=ghy_happy, createdTime=Sat Aug 06 06:41:00 CST 2016, time=2016-08-06, status=1, ipAttribution=)]
    2016-08-06 oo902

    益生菌益生

    0

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    2016-08-06 1dd8a7c5m95(暂无匿称)

    学习了,赞一个!!

    0

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    2016-08-06 1dd8a7c5m95(暂无匿称)

    学习了,赞一个!!

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=96867, encodeId=46d69686e65, content=讲的非常好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLF3V7KY7WyRVHCticgpdCWVsqAsLGF1UrrVc5TFS9ZI2DrEs5plCGBUaLqHXvCU4fhImjFdZ9PjiaS/0, createdBy=8f971728670, createdName=1dee1b88m43(暂无匿称), createdTime=Mon Aug 08 10:34:00 CST 2016, time=2016-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96419, encodeId=29aa9641995, content=学习了,太有用了, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Sat Aug 06 11:40:00 CST 2016, time=2016-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96352, encodeId=2692963524d, content=学习了,继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160528/IMG5749A60FD120A3124.jpg, createdBy=65fe1709307, createdName=青荷, createdTime=Sat Aug 06 09:26:00 CST 2016, time=2016-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96336, encodeId=5eca963363f, content=益生菌益生, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sat Aug 06 09:03:00 CST 2016, time=2016-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96296, encodeId=544396296b5, content=学习了,赞一个!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Sat Aug 06 08:47:00 CST 2016, time=2016-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96297, encodeId=ba099629e27, content=学习了,赞一个!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Sat Aug 06 08:47:00 CST 2016, time=2016-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96298, encodeId=bc1f96298e6, content=学习了,赞一个!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Sat Aug 06 08:47:00 CST 2016, time=2016-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96299, encodeId=65309629914, content=学习了,赞一个!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Sat Aug 06 08:47:00 CST 2016, time=2016-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96289, encodeId=57ac9628920, content=分人群吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Sat Aug 06 08:32:00 CST 2016, time=2016-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96275, encodeId=0112962e553, content=stop, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1b2c1297487, createdName=ghy_happy, createdTime=Sat Aug 06 06:41:00 CST 2016, time=2016-08-06, status=1, ipAttribution=)]
    2016-08-06 1dd8a7c5m95(暂无匿称)

    学习了,赞一个!!

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=96867, encodeId=46d69686e65, content=讲的非常好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLF3V7KY7WyRVHCticgpdCWVsqAsLGF1UrrVc5TFS9ZI2DrEs5plCGBUaLqHXvCU4fhImjFdZ9PjiaS/0, createdBy=8f971728670, createdName=1dee1b88m43(暂无匿称), createdTime=Mon Aug 08 10:34:00 CST 2016, time=2016-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96419, encodeId=29aa9641995, content=学习了,太有用了, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Sat Aug 06 11:40:00 CST 2016, time=2016-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96352, encodeId=2692963524d, content=学习了,继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160528/IMG5749A60FD120A3124.jpg, createdBy=65fe1709307, createdName=青荷, createdTime=Sat Aug 06 09:26:00 CST 2016, time=2016-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96336, encodeId=5eca963363f, content=益生菌益生, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sat Aug 06 09:03:00 CST 2016, time=2016-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96296, encodeId=544396296b5, content=学习了,赞一个!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Sat Aug 06 08:47:00 CST 2016, time=2016-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96297, encodeId=ba099629e27, content=学习了,赞一个!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Sat Aug 06 08:47:00 CST 2016, time=2016-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96298, encodeId=bc1f96298e6, content=学习了,赞一个!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Sat Aug 06 08:47:00 CST 2016, time=2016-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96299, encodeId=65309629914, content=学习了,赞一个!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Sat Aug 06 08:47:00 CST 2016, time=2016-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96289, encodeId=57ac9628920, content=分人群吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Sat Aug 06 08:32:00 CST 2016, time=2016-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96275, encodeId=0112962e553, content=stop, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1b2c1297487, createdName=ghy_happy, createdTime=Sat Aug 06 06:41:00 CST 2016, time=2016-08-06, status=1, ipAttribution=)]
    2016-08-06 1dd8a7c5m95(暂无匿称)

    学习了,赞一个!!

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=96867, encodeId=46d69686e65, content=讲的非常好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLF3V7KY7WyRVHCticgpdCWVsqAsLGF1UrrVc5TFS9ZI2DrEs5plCGBUaLqHXvCU4fhImjFdZ9PjiaS/0, createdBy=8f971728670, createdName=1dee1b88m43(暂无匿称), createdTime=Mon Aug 08 10:34:00 CST 2016, time=2016-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96419, encodeId=29aa9641995, content=学习了,太有用了, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Sat Aug 06 11:40:00 CST 2016, time=2016-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96352, encodeId=2692963524d, content=学习了,继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160528/IMG5749A60FD120A3124.jpg, createdBy=65fe1709307, createdName=青荷, createdTime=Sat Aug 06 09:26:00 CST 2016, time=2016-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96336, encodeId=5eca963363f, content=益生菌益生, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sat Aug 06 09:03:00 CST 2016, time=2016-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96296, encodeId=544396296b5, content=学习了,赞一个!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Sat Aug 06 08:47:00 CST 2016, time=2016-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96297, encodeId=ba099629e27, content=学习了,赞一个!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Sat Aug 06 08:47:00 CST 2016, time=2016-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96298, encodeId=bc1f96298e6, content=学习了,赞一个!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Sat Aug 06 08:47:00 CST 2016, time=2016-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96299, encodeId=65309629914, content=学习了,赞一个!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Sat Aug 06 08:47:00 CST 2016, time=2016-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96289, encodeId=57ac9628920, content=分人群吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Sat Aug 06 08:32:00 CST 2016, time=2016-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96275, encodeId=0112962e553, content=stop, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1b2c1297487, createdName=ghy_happy, createdTime=Sat Aug 06 06:41:00 CST 2016, time=2016-08-06, status=1, ipAttribution=)]
    2016-08-06 xiaotaiyang1

    分人群吗

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=96867, encodeId=46d69686e65, content=讲的非常好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLF3V7KY7WyRVHCticgpdCWVsqAsLGF1UrrVc5TFS9ZI2DrEs5plCGBUaLqHXvCU4fhImjFdZ9PjiaS/0, createdBy=8f971728670, createdName=1dee1b88m43(暂无匿称), createdTime=Mon Aug 08 10:34:00 CST 2016, time=2016-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96419, encodeId=29aa9641995, content=学习了,太有用了, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Sat Aug 06 11:40:00 CST 2016, time=2016-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96352, encodeId=2692963524d, content=学习了,继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160528/IMG5749A60FD120A3124.jpg, createdBy=65fe1709307, createdName=青荷, createdTime=Sat Aug 06 09:26:00 CST 2016, time=2016-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96336, encodeId=5eca963363f, content=益生菌益生, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=a37a1710612, createdName=oo902, createdTime=Sat Aug 06 09:03:00 CST 2016, time=2016-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96296, encodeId=544396296b5, content=学习了,赞一个!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Sat Aug 06 08:47:00 CST 2016, time=2016-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96297, encodeId=ba099629e27, content=学习了,赞一个!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Sat Aug 06 08:47:00 CST 2016, time=2016-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96298, encodeId=bc1f96298e6, content=学习了,赞一个!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Sat Aug 06 08:47:00 CST 2016, time=2016-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96299, encodeId=65309629914, content=学习了,赞一个!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRuUXgacXpPeW0x8Z3Qr9c3I2kTic4ZIpR29iaftYgkjRcbv982icYMtqANBPYBgPnOia6mVtX76qMXuc/0, createdBy=ebe61630855, createdName=1dd8a7c5m95(暂无匿称), createdTime=Sat Aug 06 08:47:00 CST 2016, time=2016-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96289, encodeId=57ac9628920, content=分人群吗, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90f31612316, createdName=xiaotaiyang1, createdTime=Sat Aug 06 08:32:00 CST 2016, time=2016-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=96275, encodeId=0112962e553, content=stop, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1b2c1297487, createdName=ghy_happy, createdTime=Sat Aug 06 06:41:00 CST 2016, time=2016-08-06, status=1, ipAttribution=)]
    2016-08-06 ghy_happy

    stop

    0

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近日,来自奥克兰大学的研究人员通过研究发现,极低热量饮食及益生菌的摄入或可帮助有效抑制2型糖尿病的发生。领导这项研究的研究者Rinki Murphy获得了新西兰健康研究委员会资助的14.9万美金用于进行益生菌对前期糖尿病的研究;他表示,有效抑制前驱糖尿病进展成为2型糖尿病非常关键,而在现实生活中我们很难通过生活方式的干预措施来进行抑制。特定的益生菌菌种抑制2型糖尿病的效应可以帮助有效降低妊娠糖尿病

研发混合益生菌或可低成本治疗肝癌

由香港大学生物系副教授Hani El-Nezami博士及Gianni Panagiotou博士领导的科研团队,与该校李嘉诚医学院及东芬兰大学医学系合作,研发出一种对肝癌具有潜在治疗效果的混合益生菌“Prohep”,有望成为治疗肝癌的一种低成本方案。

Appl Environ Microbiol:补充益生菌可降低女性患乳腺癌的风险

加拿大安大略西部大学的研究人员通过对80名乳腺癌或健康女性的乳房组织进行研究发现,通过乳房组织中的细菌种类可评估女性患乳腺癌的风险。他们发现,乳腺癌患者乳房组织内大肠杆菌和表皮葡萄球菌水平较高(对机体有害,破坏双链DNA的完整性),但乳房组织若存在高浓度的乳酸杆菌和链球菌则对机体有利。这一发现证实人们之前认为摄入益生菌酸奶和牛奶等食物可降低女性罹患乳腺癌的风险。研究结果发表在Applied and

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Diabetes Res Clin Pract:益生菌可显著降低2型糖尿病患者的空腹血糖

本研究旨在系统地评价益生菌对2型糖尿病(T2DM)干预的研究,并分析益生菌对T2DM患者血糖控制的影响。使用五个电子数据库进行电子搜索,检索日期设置为截止至2015年10月。对相关的研究进行鉴定、提取数据并评估偏倚的风险。主要研究结果是糖化血红蛋白(HbA1c)、空腹血糖(FBG)。次要研究结果为空腹胰岛素、稳态模型评估的胰岛素抵抗指数、C反应蛋白、白细胞介素-6和丙二醛。使用固定或随机效应模型汇

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