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NAT COMMUN:天然大麻素在焦虑症中起关键作用

2017-04-02 来宝网 来宝网

美国数百万人存在压力相关性情绪和焦虑症。一项最新研究对这些疾病背后的神经生物学机制进行研究后发现,控制一种激活大麻素受体的分子可以减少焦虑症状。

美国数百万人存在压力相关性情绪和焦虑症。一项最新研究对这些疾病背后的神经生物学机制进行研究后发现,控制一种激活大麻素受体的分子可以减少焦虑症状。

在美国,有超过4,000万人(即占总人口数的18%)患有焦虑症,包括临床抑郁症、恐慌症、恐惧症和创伤后应激障碍(PTSD)。

将近有700万成年人患有广泛性焦虑症,此外,估计有770万人存在创伤后应激障碍(PTSD)。

焦虑症通常由多种因素引起,其中包括基因、家族史、个人情况和生活事件以及大脑中的化学物质失衡。

发表在《自然通讯》杂志上一项最新研究,从神经生物学的角度对这些精神疾病进行了研究。具体来说,就是来自美国田纳西州纳什维尔范德堡大学医学中心的研究人员通过使用小鼠模型,对大脑的应激适应能力进行研究后发现,一种自然产生的化学物质可能在创伤后应激障碍(PTSD)和抑郁症的发生和发展过程中起了关键性作用。

这项研究的通讯作者是范德堡大学成瘾精神病学系主任Sachin Patel博士和凡德比特大学精神病学系的James G. Blakemore教授。

“这项研究表明,在自然生成大麻不足的情况下,可能导致容易罹患创伤后应激障碍(PTSD)和抑郁症的倾向性。加强这个信号系统代表着一种可以用于此类应激相关性疾病的全新治疗方法。”Sachin Patel博士如是说。

然而,使用大麻治疗焦虑症可能会出现一些不良影响,如成瘾和认知功能障碍。

原始出处:

Rebecca J. Bluett, et al.  Endocannabinoid signalling modulates susceptibility to traumatic stress exposure.  Nature Communications.Published online:
28 March 2017

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    2017-07-11 liuli5079
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    2018-02-26 liye789132251
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    2017-04-04 kcb069
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  5. [GetPortalCommentsPageByObjectIdResponse(id=2086977, encodeId=3bf520869e74f, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Tue Jul 11 02:24:00 CST 2017, time=2017-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1881843, encodeId=d93118818431c, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Feb 26 06:24:00 CST 2018, time=2018-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1272687, encodeId=3a3712e268758, content=<a href='/topic/show?id=d04f440581e' target=_blank style='color:#2F92EE;'>#大麻#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44058, encryptionId=d04f440581e, topicName=大麻)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Tue Apr 04 12:24:00 CST 2017, time=2017-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361174, encodeId=423813611e479, content=<a href='/topic/show?id=5c644406910' target=_blank style='color:#2F92EE;'>#大麻素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44069, encryptionId=5c644406910, topicName=大麻素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7387164, createdName=zhangj7108, createdTime=Tue Apr 04 12:24:00 CST 2017, time=2017-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=184813, encodeId=c4c0184813c9, content=关键危害如何, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Mon Apr 03 09:41:47 CST 2017, time=2017-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=184777, encodeId=43d7184e7734, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=74221626377, createdName=tofsw, createdTime=Mon Apr 03 08:00:06 CST 2017, time=2017-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=184678, encodeId=b14e1846e894, content=stop, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kym1A9qicflExZYSdibSZBHDyicKZZj37w4jR44fPa9DI3mVLObHAxzntpTAbwxeHvviclcw8coNrDge/0, createdBy=6dc22001775, createdName=春暖花开8785, createdTime=Sun Apr 02 22:31:32 CST 2017, time=2017-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=184666, encodeId=2d3918466651, content=学习了,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzTetibytbqFDmFITWHyBWbxU7S9MYibgPSqvu0sYteH0N6zXqbU0Kf3Mbdb7yWM1Kud3zPgYBibE2SZ/0, createdBy=da7696924, createdName=qingfengqishi5, createdTime=Sun Apr 02 22:14:24 CST 2017, time=2017-04-02, status=1, ipAttribution=)]
    2017-04-03 lovetcm

    关键危害如何

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2086977, encodeId=3bf520869e74f, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Tue Jul 11 02:24:00 CST 2017, time=2017-07-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1881843, encodeId=d93118818431c, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Feb 26 06:24:00 CST 2018, time=2018-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1272687, encodeId=3a3712e268758, content=<a href='/topic/show?id=d04f440581e' target=_blank style='color:#2F92EE;'>#大麻#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44058, encryptionId=d04f440581e, topicName=大麻)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=87b1109, createdName=kcb069, createdTime=Tue Apr 04 12:24:00 CST 2017, time=2017-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361174, encodeId=423813611e479, content=<a href='/topic/show?id=5c644406910' target=_blank style='color:#2F92EE;'>#大麻素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44069, encryptionId=5c644406910, topicName=大麻素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7387164, createdName=zhangj7108, createdTime=Tue Apr 04 12:24:00 CST 2017, time=2017-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=184813, encodeId=c4c0184813c9, content=关键危害如何, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Mon Apr 03 09:41:47 CST 2017, time=2017-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=184777, encodeId=43d7184e7734, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=74221626377, createdName=tofsw, createdTime=Mon Apr 03 08:00:06 CST 2017, time=2017-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=184678, encodeId=b14e1846e894, content=stop, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kym1A9qicflExZYSdibSZBHDyicKZZj37w4jR44fPa9DI3mVLObHAxzntpTAbwxeHvviclcw8coNrDge/0, createdBy=6dc22001775, createdName=春暖花开8785, createdTime=Sun Apr 02 22:31:32 CST 2017, time=2017-04-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=184666, encodeId=2d3918466651, content=学习了,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzTetibytbqFDmFITWHyBWbxU7S9MYibgPSqvu0sYteH0N6zXqbU0Kf3Mbdb7yWM1Kud3zPgYBibE2SZ/0, createdBy=da7696924, createdName=qingfengqishi5, createdTime=Sun Apr 02 22:14:24 CST 2017, time=2017-04-02, status=1, ipAttribution=)]
    2017-04-03 tofsw

    学习了谢谢分享

    0

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    2017-04-02 春暖花开8785

    stop

    0

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    2017-04-02 qingfengqishi5

    学习了,学习了

    0

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焦虑症,又称为焦虑性神经症,是神经症这一大类疾病中最常见的一种,以焦虑情绪体验为主要特征。目前病因尚不明确,可能与遗传因素、个性特点、认知过程、不良生活事件、生化、躯体疾病等均有关系。本文小编为大家汇总相关研究进展,与大家分享。【1】Diabetes Care:2型糖尿病合并抑郁症和焦虑症状对死亡率风险有何影响? 近日,糖尿病领域权威杂志Diabetes Care发表了一篇研究文章,

Lancet Psych:焦虑增加抑郁风险

焦虑和抑郁障碍共病发病风险极高,且增加了全球疾病负担。然而并没有大规模的研究来描述两者之间的关系。在本回顾性研究中,研究人员旨在评估严重焦虑障碍对抑郁发生风险和抑郁症进程的影响。 研究人员对来自丹麦的人口登记系统的数据进行了一项人群队列研究,这些数据来自三个不同丹麦人口登记系统:丹麦民事登记系统,丹麦精神病中心注册,丹麦国家医院。研究人员纳入了从1955年1月1日至2002年12月31日间出生在丹

PLoS One:“工作狂”容易出现强迫症、焦虑症?

一项新的研究表明,与具有较好的工作、生活平衡能力的人群相比,工作狂可能容易产生精神健康障碍。 该项研究的作者表示,这些精神健康障碍可能包括:焦虑、注意力缺陷多动障碍(ADHD),强迫症(OCD)和抑郁症等。 在该项研究中,研究这么难对15,000多名挪威人的相关信息进行了评估,研究结果表明,“极端的工作状态,可能会引起人们更深层次的精神问题,”该研究报告的主要作者 Cecili

Lancet:严重的焦虑症后易患继发性抑郁症!

背景:抑郁症和焦虑症是高度合并症,并且成为全球的疾病负担;然而,描述它们之前的联系的大规模的研究却很少。在这项回顾性研究中,主要目的是评估严重焦虑症对抑郁症过程及风险的影响。      方法:研究人员使用从丹麦的三个人口登记所收集到的数据,做了这个前瞻性、以人群为基础的队列研究,三个人口登记系统包括:丹麦民事登记系统、丹麦精神病中央登记册和丹麦国家医院登记处。

Inflamm Bowel Dis:生理健康与心理健康的联系--伴有IBD者更易发生焦虑症

研究发现,广泛性焦虑症更常见于伴有克罗恩病或溃疡性结肠炎的个体。据多伦多大学研究人员发表于《炎症性肠病 》的一项新的研究表明,伴有炎症性肠道疾病(IBD)——如克罗恩病或溃疡性结肠炎——的个体发生广泛性焦虑症的风险为不伴有IBD的同龄人的两倍。“伴有IBD的患者面对着大量与此疾病相关的慢性身体问题,”由桑德拉•罗特曼在多伦多大学茵文特许社会工作学院授予职位的Esme Fuller-Tho

焦虑症或许会导致患癌男性过早死亡

全球大约14个人中就有1人在一生的某个特定时间里就会收到焦虑症的困扰,那些遭受焦虑症困扰的患者都会经历机体损伤、残疾等状况,同时还会处于高风险的药物滥用以及自杀状况之中;尽管存在相当大的风险,但科学家们对焦虑症的研究还远远滞后于对其它常见精神健康问题的研究,甚至很多患者都并不知道自己是焦虑症患者。 在很多时候,甚至过了十几年,焦虑症患者才会去找医生寻求治疗方法,然而这么长的时间往往会给患

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