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JACC:老年低心血管风险的预测因子的探索

2019-07-17 不详 MedSci原创

心血管疾病风险随着年龄的增加而急剧增加,导致他汀类药物在老年人中的应用非常普遍。为了避免过度治疗,要识别出那些真正心血管病低风险的老年人。本研究的目的旨在找出可以预测老年人短期低冠心病和心血管疾病风险的阴性标志物。本研究纳入分析了5805名研究对象(平均年龄69岁,随访平均时间为2.7年),并对13个候选标志物进行了分析:冠脉钙评分(CAC)=0,CAC≤10,无颈动脉斑块,无家族史,踝臂指数正常

血管疾病风险随着年龄的增加而急剧增加,导致他汀类药物在老年人中的应用非常普遍。为了避免过度治疗,要识别出那些真正心血管病低风险的老年人。本研究的目的旨在找出可以预测老年人短期低冠心病和心血管疾病风险的阴性标志物。


本研究纳入分析了5805名研究对象(平均年龄69岁,随访平均时间为2.7年),并对13个候选标志物进行了分析:冠脉钙评分(CAC)=0,CAC≤10,无颈动脉斑块,无家族史,踝臂指数正常和脂蛋白A1>75百分位等。分析结果显示,CAC=0和CAC≤10是预测冠心病和心血管疾病低风险最强的阴性标志物,其次是半乳糖凝集素-3<第25百分位和颈动脉斑块的缺失,其他候选标志物的预测效果较差。


研究结果显示,CAC=0、CAC≤10、低半乳糖凝集素-3和无颈动脉斑块老年人短期低心血管疾病风险有较好的预测价值。


原始出处:

Martin B et al.Negative Risk Markers for Cardiovascular Events in the Elderly.JACC.2019 July.


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    2020-03-05 hbwxf
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