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J Urol:前列腺癌男性患者中循环肿瘤细胞的鉴定和分析

2019-07-08 AlexYang MedSci原创

大约15%新诊断的前列腺癌男性具有高风险特性,这些特性能够增加复发和转移的风险。更好的预测生物标记可以进行生化复发(BCR)的检测、调整监控措施和辅助治疗方式。循环肿瘤细胞(CTCs)代表了转移的最早形式,然而它们在高风险局部前列腺癌(HRLPCa)男性中作为生物标记还没有很好的鉴定。研究人员从37名经历前列腺切术术后2-5个月的HRLPCa患者中抽取了血液样本。研究发现,在81.1%(30/37

大约15%新诊断的前列腺癌男性具有高风险特性,这些特性能够增加复发和转移的风险。更好的预测生物标记可以进行生化复发(BCR)的检测、调整监控措施和辅助治疗方式。循环肿瘤细胞(CTCs)代表了转移的最早形式,然而它们在高风险局部前列腺癌(HRLPCa)男性中作为生物标记还没有很好的鉴定。

研究人员从37名经历前列腺切术术后2-5个月的HRLPCa患者中抽取了血液样本。研究发现,在81.1%(30/37)的样本中检测到了CTCs,均值为2.4 CTCs/ml (范围: 0-22.9)。具有可检测CTCs的患者表现出了更短复发时间的倾向(p=0.12),并且所有具有BCR的患者均具有可检测的CTCs。研究人员还在18.9%的患者中检测到了AR的过表达。具有BCR的患者具有更多的CTC拷贝数变异(CNAs, p=0.027)。匹配的肿瘤组织和单个CTC测序阐释了具有异质性。

最后,研究人员指出,RP后具有高的CTC可检测发生率,在具有更高CTC的患者中BCR发生的更快。另外,早期CTRC检测也许可以作为协助辅助治疗决定的良好生物标记。

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    2019-07-09 misszhang

    前列腺癌相关研究,学习了,谢谢梅斯

    0

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