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Autophagy:视网膜母细胞瘤中miR-34a与HMGB1结合调控肿瘤凋亡的发生

2014-05-31 王春晓 成舸 中国科学报

从中南大学湘雅二医院获悉,该院眼科在视网膜母细胞瘤细胞自噬及凋亡的研究中取得新突破,有望提高该病及其他眼内恶性肿瘤的化疗疗效,逐渐取代眼球摘除治疗方法。该研究日前发表于《自噬》。据了解,这项研究证实了一种名为miR-34a的微小核糖核酸可以降低肿瘤细胞中的高迁移率核蛋白1(HMGB1)号的遗传信息传递,从而促进肿瘤细胞的凋亡并抑制其自噬。同时,miR-34a还能通过增加细胞DNA的损伤来提

从中南大学湘雅二医院获悉,该院眼科在视网膜母细胞瘤细胞自噬及凋亡的研究中取得新突破,有望提高该病及其他眼内恶性肿瘤的化疗疗效,逐渐取代眼球摘除治疗方法。该研究日前发表于《自噬》。

据了解,这项研究证实了一种名为miR-34a的微小核糖核酸可以降低肿瘤细胞中的高迁移率核蛋白1(HMGB1)号的遗传信息传递,从而促进肿瘤细胞的凋亡并抑制其自噬。同时,miR-34a还能通过增加细胞DNA的损伤来提高化疗药物的治疗效果。

miR-34a是备受关注的一种微小核糖核酸。它通过调控多靶分子参与调节细胞的增殖与凋亡,在细胞分化、生物发育与疾病的发生、发展过程中发挥着重要作用。该研究揭示出miR-34a在细胞自噬作用中的新机制,为临床治疗该疾病以及其他眼内恶性肿瘤提供了新的思路与方法。

视网膜母细胞瘤是婴幼儿眼病中性质最严重、危害性最大的恶性肿瘤,若未得到及时治疗,将危及患儿生命。过去,临床上常通过摘除眼球来治疗这一疾病。

原始出处:


Liu K, Huang J, Xie M, Yu Y, Zhu S, Kang R, Cao L, Tang D, Duan X.MIR34A regulates autophagy and apoptosis by targeting HMGB1 in the retinoblastoma cell. Autophagy. 2014 Mar;10(3):442-52.

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    2014-10-18 xzw113
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    2014-10-20 smallant2002
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    2014-06-02 zutt
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