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Neurochem Int:长期口服激动素不能治疗α-突触核蛋白诱导的帕金森病!

2017-07-08 Emma MedSci原创

有研究表明,PINK1是与帕金森病遗传相关的线粒体激酶,线粒体激酶PTEN诱导的PINK1突变可能通过破坏PINK1的激酶活性,导致PD。三磷酸激动素, 是一种激活PINK1的野生型和突变体形式的小分子,其能够影响线粒体功能,激动素是三磷酸激动素前体。发表于Neurochem Int的一篇文章中,研究人员以大鼠作为PD临床前啮齿动物模型,长期饲喂激动素,探究PINK1活性的增加是否对PD有治疗

帕金森病(Parkinson's disease,PD)是一种常见的神经系统变性疾病,老年人多见,平均发病年龄为60岁左右,40岁以下起病的青年帕金森病较少见。我国65岁以上人群PD的患病率大约是1.7%。帕金森病最主要的病理改变是中脑黑质多巴胺(dopamine,DA)能神经元的变性死亡,由此而引起纹状体DA含量显著性减少而致病。导致这一病理改变的确切病因目前仍不清楚,遗传因素、环境因素、年龄老化、氧化应激等均可能参与PD多巴胺能神经元的变性死亡过程。α-突触核蛋白是一种在中枢神经系统突触前及核周表达的可溶性蛋白质,它与帕金森病的发病机制和相关功能障碍密切相关,是路易小体的主要成分。有研究表明,PINK1是与帕金森病遗传相关的线粒体激酶,线粒体激酶PTEN诱导的PINK1突变可能通过破坏PINK1的激酶活性,导致PD。三磷酸激动素,是一种激活PINK1的野生型和突变体形式的小分子,其能够影响线粒体功能,激动素是其前体。发表于Neurochem Int的一篇文章中,研究人员以大鼠作为PD临床前啮齿动物模型,长期饲喂激动素,探究PINK1活性的增加是否对PD有治疗作用。结果显示,长期口服

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    2018-06-15 linlin2312
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    2017-07-11 虈亣靌

    不错的方式,努力学习,刻苦专研,不断总结出来新经验。

    0

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    2017-07-10 周周人

    学习。

    0

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    2017-07-09 Lisa971

    帕金森疾病,脑病科常见,需要系统学习的内容。

    0

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