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J Clin Periodontol: 社区老年人维生素D受体基因多态性与慢性肾病及牙周病易感性的关系

2018-06-30 MedSci MedSci原创

这项研究的目的是调查维生素D受体(VDR)基因多态性与慢性肾病(CKD)和牙周病易感性之间的可能相关性。

这项研究的目的是调查维生素D受体(VDR)基因多态性与慢性肾病(CKD)和牙周病易感性之间的可能相关性。

这项研究分析了345名79岁的参与者。基于估计的肾小球滤过率(eGFR;非还原功能:≥60和功能降低:<60ml min -11.73m-2)确定肾功能水平。还研究了VDR TaqI基因分型。计算牙周炎症表面积(PISA)。根据eGFR或PISA值将参与者分成四等分组之后,将受试者分成两组(最高四分位组vs其他三组)。多因素logistic回归分析评估eGFR和VDR TaqI基因型与不同PISA组之间的比值比。将eGFR设定为因变量,而将VDR TaqI基因型,HbA1C,性别,吸烟习惯和体重指数定义为独立变量。

结果:在PISA高组中VDR TaqI基因型和eGFR之间观察到显着相关性(优势比= 3.97,p = .027)。

研究结果表明VDR TaqI基因型可能与牙周疾病引起的炎症状态下的CKD相关。

原始出处:


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    2018-10-24 feather89
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objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sun Jul 01 01:31:16 CST 2018, time=2018-07-01, status=1, ipAttribution=)]
    2018-07-01 三生有幸9135

    学习一下

    0

  8. 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objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sun Jul 01 01:31:16 CST 2018, time=2018-07-01, status=1, ipAttribution=)]
    2018-07-01 12225669m29暂无昵称

    学习

    0

  9. 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objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sun Jul 01 01:31:16 CST 2018, time=2018-07-01, status=1, ipAttribution=)]
    2018-07-01 深海的鱼

    学习学习学习

    0

  10. 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objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sun Jul 01 01:31:16 CST 2018, time=2018-07-01, status=1, ipAttribution=)]
    2018-07-01 1e145228m78(暂无匿称)

    学习了.谢谢作者分享!

    0

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