帕金森运动症状治疗的新方法：鞘内注射仙人掌毒素

2019-04-11 不详网络

帕金森病（PD）是一种慢性神经退行性疾病，其特征在于运动症状，例如运动迟缓、静止性震颤、姿势紊乱和僵硬。许多临床和病理学研究表明，PD病变能够延伸到黑质以外，并且涉及非多巴胺能神经递质系统，其能够介导运动和非运动症状。Sorrento Therapeutics公司近日宣布，仙人掌毒素（Resiniferatoxin，RTX）能够控制PD的运动症状。

帕金森病（PD）是一种慢性神经退行性疾病，其特征在于运动症状，例如运动迟缓、静止性震颤、姿势紊乱和僵硬。许多临床和病理学研究表明，PD病变能够延伸到黑质以外，并且涉及非多巴胺能神经递质系统，其能够介导运动和非运动症状。Sorrento Therapeutics公司近日宣布，仙人掌毒素（Resiniferatoxin，RTX）能够控制PD的运动症状。

单次鞘内注射Resiniferatoxin对AAV-A53T诱导的PD样病理模型（C57Bl / 6J小鼠）的结果显示，在AAV-A53T后7天鞘内施用Resiniferatoxin能够显著改善精细运动功能，且Resiniferatoxin输注后小鼠没有明显的不良反应。然而，没有观察到纹状体中多巴胺及其代谢物水平的变化。

原始出处：

http://www.firstwordpharma.com/node/1634400#axzz5kmtmGZrh

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2019-04-24 kord1982

#新方法#

81 0
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2019-12-01 ycmayy

#仙人掌毒素#

62 0
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2019-04-18 jin321

厉害

135 0
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2019-04-16 一个字-牛

学习了谢谢分享

119 0
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2019-04-13 坚强007

向科研人员致敬！

1 0
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2019-04-13 sunrural_42825363

#运动症状#

82 0
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2019-04-13 zywlvao

#鞘内注射#

60 0
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2019-04-11 329523732

不错

131 0

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