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NEJM:埃博拉病毒幸存者后遗症分析

2019-03-07 xing.T 网络

由此可见,所有参与者都出现了相对较高的症状负担,但某些症状和检查结果在幸存者中更常见。除葡萄膜炎外,两组患者在随访期间患病率均有所下降。精液中的病毒RNA持续时间最多40个月。

埃博拉病毒病(EVD)幸存者报告了多种健康问题。在没有对照组进行分析的情况下将这些问题归因于疾病是极为困难的。

近日,顶级医学期刊NEJM上发表了一篇研究文章,研究人员招募了一组EVD幸存者及其密切接触者,并前瞻性地收集了有关症状、体格检查结果和实验室检查结果的数据。一部分参与者接受了眼科检查,并确定了来自幸存者精液样品中埃博拉病毒(EBOV)RNA的持久性。

该研究共招募了966名EBOV抗体阳性幸存者和2350名抗体阴性密切接触者(对照者),并且90%的这些参与者被随访了12个月。在入组时(基线就诊的中位时间为症状发作后358天),幸存者中报告的6种症状明显多于对照组:尿频(14.7% vs. 3.4%)、头痛(47.6% vs. 35.6%)、疲劳(18.4% vs. 6.3%)、肌肉疼痛(23.1% vs. 10.1%)、记忆力减退(29.2% vs. 4.8%)和关节疼痛(47.5% vs. 17.5%)。在检查中,比对照组更多的幸存者有异常的腹部、胸部、神经和肌肉骨骼体征和葡萄膜炎。除葡萄膜炎外(入组时患病率为26.4% vs. 12.1%;第1年为33.3% vs. 15.4%),这些疾病的患病率在随访期间均有所下降。幸存者中大多数症状、神经系统体征和葡萄膜炎的发生率高于对照组。在30%的受试幸存者的精液样本中检测到EBOV的RNA,最长时间从发病到40个月。 

由此可见,所有参与者都出现了相对较高的症状负担,但某些症状和检查结果在幸存者中更常见。除葡萄膜炎外,两组患者在随访期间患病率均有所下降。精液中的病毒RNA持续时间最多40个月。 

原始出处:

The PREVAIL III Study Group,et al.A Longitudinal Study of Ebola Sequelae in Liberia.NEJM.2019.https://www.nejm.org/doi/full/10.1056/NEJMoa1805435

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    2019-03-08 huirong
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    2019-03-08 183****7028

    学习

    0

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    2019-03-07 明月清辉

    谢谢分享,学习了

    0

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