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Br J Cancer:分次放疗联合血管靶向光动力疗法可增强对前列腺癌的抗肿瘤作用

2021-06-23 xiaozeng MedSci原创

分次放疗(FRT)联合雄激素剥夺疗法(ADT)是前列腺癌(PCa)的一种治疗选择,然而,三分之一的患者会出现复发,且患者后续的治疗选择有限。

分次放疗(FRT)联合雄激素剥夺疗法(ADT)是前列腺癌(PCa)的一种治疗选择,然而,三分之一的患者会出现复发,且患者后续的治疗选择有限。

此外,FRT和ADT具有显著的副作用。根治性手术(前列腺切除术)是PCa的另一种治疗选择,但也同样有显著的副作用。因此,急需制定改善PCa治疗结果和减少治疗副作用的治疗策略。

血管靶向光动力疗法(VTP)是一种新型的微创局部消融外科手术,其主要是通过自由基介导的快速破坏肿瘤血管系统来实现的。VTP可有效用于低风险小体积的PCa的局部消融,并已被作为放疗复发PCa的一种挽救疗法。


肿瘤血管系统的特征在于血管不成熟、渗透性增加、异常的分支以及低效的流动。FRT能够改变肿瘤微环境并促进短暂的“血管正常化”。在该研究中,研究人员假设,相比于FRT或VTP的单独治疗,二者联合的多模式治疗可以改善对PCa的控制。

VTP会导致移植瘤的生长延迟

研究人员在临床前PCa模型中研究了该假设,分析连续递送FRT和7天后的VTP治疗是否能够改善对TRAMP-C1 PCa侧翼移植瘤的控制。


结果显示,FRT能够诱导PCa侧翼移植瘤中的“血管正常化”变化,并改善相关血管功能,而相比于FRT或VTP的单独治疗,FRT后联合VTP治疗能够显著延迟移植瘤模型中的肿瘤生长,并提高总生存率。

新辅助FRT联合7天后VTP治疗可提高患者的疗效

总而言之,该研究结果揭示,FRT和VTP的联合治疗或可成为PCa治疗中的一种具有潜力的多模式治疗策略。这也为该多模式治疗策略提供了概念验证,为后续的早期临床试验提供一定的理论基础。


原始出处:

Sjoberg, H.T., Philippou, Y., Magnussen, A.L. et al. Tumour irradiation combined with vascular-targeted photodynamic therapy enhances antitumour effects in pre-clinical prostate cancer. Br J Cancer (21 June 2021).

 

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1546334, encodeId=717f1546334a1, content=<a href='/topic/show?id=0da528e33ce' target=_blank style='color:#2F92EE;'>#光动力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28733, encryptionId=0da528e33ce, topicName=光动力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2b6213920685, createdName=luckyshitiancai_42705688, createdTime=Thu Jun 24 15:34:27 CST 2021, time=2021-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976028, encodeId=604f9e60282c, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=b3545492917, createdName=smart Ren, createdTime=Wed Jun 23 07:46:42 CST 2021, time=2021-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976012, encodeId=91289e6012f5, content=好文章,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Wed Jun 23 06:43:39 CST 2021, time=2021-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1041030, encodeId=b1561041030d0, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Jun 23 03:34:27 CST 2021, time=2021-06-23, status=1, ipAttribution=)]
    2021-06-23 smart Ren

    学习学习

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1546334, encodeId=717f1546334a1, content=<a href='/topic/show?id=0da528e33ce' target=_blank style='color:#2F92EE;'>#光动力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28733, encryptionId=0da528e33ce, topicName=光动力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2b6213920685, createdName=luckyshitiancai_42705688, createdTime=Thu Jun 24 15:34:27 CST 2021, time=2021-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976028, encodeId=604f9e60282c, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=b3545492917, createdName=smart Ren, createdTime=Wed Jun 23 07:46:42 CST 2021, time=2021-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976012, encodeId=91289e6012f5, content=好文章,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Wed Jun 23 06:43:39 CST 2021, time=2021-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1041030, encodeId=b1561041030d0, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Jun 23 03:34:27 CST 2021, time=2021-06-23, status=1, ipAttribution=)]
    2021-06-23 yangchou

    好文章,谢谢分享。

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1546334, encodeId=717f1546334a1, content=<a href='/topic/show?id=0da528e33ce' target=_blank style='color:#2F92EE;'>#光动力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28733, encryptionId=0da528e33ce, topicName=光动力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2b6213920685, createdName=luckyshitiancai_42705688, createdTime=Thu Jun 24 15:34:27 CST 2021, time=2021-06-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976028, encodeId=604f9e60282c, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=b3545492917, createdName=smart Ren, createdTime=Wed Jun 23 07:46:42 CST 2021, time=2021-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=976012, encodeId=91289e6012f5, content=好文章,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Wed Jun 23 06:43:39 CST 2021, time=2021-06-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1041030, encodeId=b1561041030d0, content=前列腺癌相关研究,学习了,谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed Jun 23 03:34:27 CST 2021, time=2021-06-23, status=1, ipAttribution=)]
    2021-06-23 misszhang

    前列腺癌相关研究,学习了,谢谢梅斯

    0

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