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9 大癌种白蛋白结合型紫杉醇临床应用,只此一篇就够了!

2022-06-14 网络 网络

一文带你掌握白蛋白结合型紫杉醇!

​白蛋白结合型紫杉醇纳米颗粒是一种新型的紫杉醇制剂,使用人血清白蛋白将疏水性的紫杉醇分子包裹在约 130nm 颗粒中。白蛋白可通过与 gp60 受体结合等途径增加紫杉醇在肿瘤中的摄取,从而增强药物的跨内皮转运,提高肿瘤组织内紫杉醇的浓度。

 

本文归纳总结白蛋白结合型紫杉醇临床应用,以期对临床有些许帮助。

 

一、乳腺癌

 

白蛋白紫杉醇批准用于治疗联合化疗失败的转移性乳腺癌或辅助化疗后 6 个月内复发的乳腺癌 (除非有临床禁忌症,既往化疗中应包括一种蒽环类抗癌药)。此外,据研究提示三阴性乳腺癌新辅助治疗中,白蛋白紫杉醇比溶剂型紫杉醇有更高的 pCR 率,同时能够改善患者 DFS。

 

二、胰腺癌
 
三、肺癌

 

四、卵巢癌
五、黑色素瘤

六、胆道系统肿瘤

七、胆道肿瘤及胰腺癌腹腔化疗
八、食管癌
九、鼻咽癌

参考文献

1. 山东省超药品说明书用药专家共识(2021 年版)

2. 中国胰腺癌新辅助治疗指南 (2020 版)

3. 中国胰腺癌诊治指南(2021)

4. NCCN 卵巢癌 (包括输卵管癌和原发性腹膜癌)(2021 V3)

5. NCCN 皮肤黑色素瘤 (2021 V2)

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    2022-09-07 SHIRLEY L99999

    请问 白蛋白结合型紫杉醇 已经用了六周期效果不错。 不知最多可以用几次 三周一个疗程、 D1 注射用紫杉醇(白蛋白结合型)100mg*4 特瑞普利 80mg*3=240mg 每三周注射一次

    0

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    2022-06-16 珙桐

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map