Sci Signal：精神压力对大脑和行为的影响

2018-03-12 药明康德学术经纬

包括促肾上腺皮质激素释放因子(corticotropin-releasing factor， CRF)在内的应激激素可能抑制大脑中由多巴胺信号通路媒介的奖励信号。

包括促肾上腺皮质激素释放因子(corticotropin-releasing factor， CRF)在内的应激激素可能抑制大脑中由多巴胺信号通路媒介的奖励信号。因此，严重或慢性精神压力与抑郁症相关，并且可以影响人们大脑做决定的过程。早期童年的精神压力可能与长期精神健康问题和行为障碍相关。健康科学统一服务大学 (Uniformed Services University of the Health Sciences) 的研究人员通过对大脑切片模型和母爱剥夺 (maternal deprivation) 的小鼠的研究，发现CRF和早期母爱剥夺会导致小鼠外侧缰核 (lateral habenula， LHb) 中神经元的兴奋性升高，而缰核是大脑中抑制多巴胺通路的区域。CRF通过与CRFR1受体结合，激活蛋白激酶A (protein kinase A， PKA)，导致钾离子通道的表达下降，从而提高LHb神经元的兴奋性。抑制PKA活性或者激活钾离子通道可以防止CRF和母爱剥夺对LHb神经元的影响。这项研究指出了治疗由于中枢神经系统CRF分泌失调造成疾病的潜在药物学靶点。

原始出处：

Michael E. Authement，et al.A role for corticotropin-releasing factor signaling in the lateral habenula and its modulation by early-life stress.Sci Signal.06 Mar 2018：Vol. 11， Issue 520， eaan6480

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2018-12-21 楚秀娟

#Sign#

62 0
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2018-08-19 yaanren

#Signal#

85 0
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2018-03-14 dangious

#精神压力#

62 0
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2018-03-12 ann y

精神压力对大脑和行为产生影响

86 0
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2018-03-12 ann y

精神压力对大脑和行为产生影响

84 0
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2018-03-12 changjiu

学习一下谢谢

101 0
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2018-03-12 医者仁心5538

好.学习了.

93 0

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