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JCLA：HLA‐DQA1基因多态性与中国人群儿童原发性肾病综合征风险的关系

2019-05-16 不详 网络

儿童原发性肾病综合征风险
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近年来，研究人员逐渐发现基因多态性与原发性肾病综合征(PNS)发病风险之间可能存在一定的关系。本研究旨在探讨HLA‐DQA1基因单核苷酸多态性(SNPs)与PNS发病风险的关系。

近年来，研究人员逐渐发现基因多态性与原发性肾病综合征(PNS)发病风险之间可能存在一定的关系。本研究旨在探讨HLA‐DQA1基因单核苷酸多态性(SNPs)与PNS发病风险的关系。

本研究对501例PNS患者和532例健康人HLA‐DQA1基因中的8个单核苷酸多态性(SNPs)进行了基因分型。然后我们分析了这些snp与中国人群原发性肾病综合征的临床特征之间的关系。

研究人员在HLA‐DQA1基因的missense SNP rs1129740 (GG vs AA, odds ratio (OR) = 1.987, 95%置信区间(CI) = 1.468‐2.652,P = 0.00177049)和rs1047992 (AA vs GG, OR = 1.857, 95% CI = 1.325‐2.391,P = 1.1073E‐10)上发现了与PNS的显著关联。

本研究提示HLA‐DQA1的SNPs是中国人群PNS的危险因素，提示免疫应答在PNS发病机制中发挥作用。

原始出处：

Bingbing Zhu,  Ruifeng Zhang ,Association of HLA‐DQA1 gene polymorphisms with the risk of children primary nephrotic syndrome in Chinese population

本文系梅斯医学（MedSci）原创编译整理，转载需授权！


 

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    2019-11-21 jiyangfei

    #原发性#

    0

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    2020-02-21 limedical1974

    #风险的关系#

    0

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    2019-05-18 zhouqu_8

    #综合征#

    0

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    2019-05-18 marongnuan

    #HLA#

    0

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    2019-05-18 xzw120

    #多态性#

    0

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