CLIN CNACER RES：Foretinib一线治疗晚期肝细胞癌临床试验结果

2017-05-23 MedSci MedSci原创

Foretinib是一种口服MET、ROS、RON、AXL、TIE-2、VEGFR2多激酶抑制剂。CLIN CANCER RES近期报道了一篇文章，研究Foretinib一线治疗晚期肝细胞癌的治疗效果。

Foretinib是一种口服MET、ROS、RON、AXL、TIE-2、VEGFR2多激酶抑制剂。CLIN CANCER RES近期报道了一篇文章，研究Foretinib一线治疗晚期肝细胞癌的治疗效果。

在Ⅰ期试验中，晚期肝细胞癌患者每天接受标准3+3设计递增剂量的Foretinib（30-60mg）治疗。达到最大耐受剂量（MTD）后，32例患者按最大耐受剂量进行Ⅱ期试验，评估Foretinib有效性及安全性。作者还分析了可能与临床疗效及预后有关额潜在分子指标。研究结果表明，Foretinib的最大耐受剂量为30mg每天。最常见的不良反应为高血压、食欲下降、腹水及发热。Foretinib30mg每天作为一线治疗具有良好的抗肿瘤活性。客观反映率为22.9%，病情稳定率为82.9%，中位反应时间为7.6个月。中位疾病进展时间为4.2个月，中位总生存时间15.7个月。循环系统中15个潜在的对Foretinib治疗反应的分子标志水平显着改变。多因素分析表明IL6和IL8是总生存的独立预测因素。

文章最后认为，对于亚洲晚期肝细胞癌患者，Foretinib作为一线治疗药物具有良好的抗肿瘤活性且耐受性良好。血清IL6及IL8水平可以预测对Foretinib的反应。

原始出处：

Thoma C.C.Yau,Riccardo Lencioni,et al.A PhaseⅠ/Ⅱ Multicenter Study of Single-Agent Foretinib as First-Line Therapy in Patients with Advanced Hepatocellular Carcinoma.CLIN CANCER RES.May 2017 doi:10.1158/1078-0432.CCR-16-1789

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2018-04-28 jml2009

#ACER#

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2017-10-05 ysjykql

#RET#

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2018-02-07 jml2009

#ACER#

73 0
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2017-09-17 xjy02

#肝细胞#

94 0
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2017-07-14 shanyongle

#ACE#

84 0
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2018-04-25 qingting

#细胞癌#

68 0
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2017-05-25 hb2008ye

#晚期肝细胞癌#

62 0
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2017-05-23 cqykthl

又是一个新药诞生了

98 0
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2017-05-23 daiyaozu

学习了，不错

100 0

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