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JCEM:中国老年人血清25-羟维生素D、白蛋白与死亡率

2020-06-06 MedSci原创 MedSci原创

血清25(OH)D和白蛋白水平与中国老年人的全因死亡率成负相关。白蛋白水平较高的参与者中25(OH)D与死亡率之间的关联更为明显。

血清25-羟基维生素D[25(OH)D]浓度与全因死亡率之间的关联在现有文献中报道不一致。一个可能的原因是维生素D与其他疾病(例如营养不良和慢性炎症)之间存在相互作用。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,研究人员旨在探讨血清25(OH)D、白蛋白与全因死亡率之间的关系,并进一步评估其在老年人中的相互作用。

这项基于人口的纵向研究,研究人员收集了1834名年龄在65岁至112岁之间的受试者2011年为基线测定的血清25(OH)D和白蛋白数据,并在2014年和2018年的后续调查中确定了参与者的生存状况。该研究的主要观察指标为全因死亡率。

在1834名参与者中,血清25(OH)D和白蛋白浓度与全因死亡率成负相关(Ps<0.001)。此外,参与者之间观察到25(OH)D和白蛋白与全因死亡率之间存在相互作用(P=0.001)。在白蛋白水平较高(≥40g/L)的组中,25(OH)D水平较低(<50nmol/L)的参与者死亡风险高于同龄人(风险比为1.92,95%置信区间=1.45-2.56),并且该关联在女性中更为明显。在白蛋白水平较低(<40 g/L)的组中,在所有参与者以及女性和男性参与者中,该关联均未达到统计学意义。

由此可见,血清25(OH)D和白蛋白水平与中国老年人的全因死亡率成负相关。白蛋白水平较高的参与者中25(OH)D与死亡率之间的关联更为明显。

原始出处:

Xurui Jin,et al.Serum 25-Hydroxyvitamin D, Albumin, and Mortality among Chinese Older Adults: A Population-based Longitudinal Study.JCEM.2020.https://doi.org/10.1210/clinem/dgaa349

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    2021-01-03 smallant2015
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    2021-04-17 achengzhao
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    2020-06-08 珙桐
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    2020-06-06 lovetcm

    #维生素D#血清25(OH)D和白蛋白水平与中国老年人的全因死亡率成负相关。不代表补充维生素D就能减少死亡风险哦

    0

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