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Stroke:急性脑出血患者生理评分异常与预后的关系

2021-01-14 MedSci原创 MedSci原创

近日,心血管疾病领域权威杂志Stroke上发表了一篇研究文章,研究人员旨在明确生理指标(收缩压、血糖和体温)异常和华法林使用与自发性脑出血患者预后之间的关系。

近日,血管疾病领域权威杂志Stroke上发表了一篇研究文章,研究人员旨在明确生理指标(收缩压、血糖和体温)异常和华法林使用与自发性脑出血患者预后之间的关系。

研究人员对急性脑出血试强化降压治疗(INTERACT2)试验进行事后分析,比较了2839例脑出血高血压患者(发病时间<6小时)收缩压控制情况(<140 vs. <180mmHg)。多变量logistic回归确定了基线得分(收缩压每升高10mmHg基线得分为0至6(范围为150至220 mmHg)、血糖(≤6.5 与 >6.5 mmol/L)为0或1、体温(≤37.5°C vs. >37.5°C)、使用华法林(否与是)以及死亡或严重残疾(在90天时经修正的Rankin量表得分为3-6))与预后之间的关联。

基线得分分布为0分(7.7%)、1分(15.6%)、2分(19.0%)、3分(19.1%)、4分(15.2%)、5分(11.6%)、6分(8.9%)和7分(2.9%)。在调整了基线神经严重程度和潜在的混杂因素之后,生理得分(每分)升高与死亡或重大残疾(比值比为1.12[95%CI为1.07-1.17])、死亡(比值比为1.15[95%CI为1.07-1.23])和严重残疾(比值比为1.10[95%CI为1.05-1.15])。

由此可见,生理参数异常和华法林使用情况相结合与脑出血患者预后不良相关

原始出处:

Lili Song.et al.Associations of an Abnormal Physiological Score With Outcomes in Acute Intracerebral Hemorrhage
INTERACT2 Study.stroke.2021.https://www.ahajournals.org/doi/10.1161/STROKEAHA.120.030435

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