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PLOS ONE:提高维生素D水平可降低癌症风险

2016-04-14 MedSci MedSci原创

高维生素D水平可使癌症风险降低超过65%,该研究结果于4月6日发表在PLOS ONE。上述结果来自一项随机试验和一项前瞻性队列研究的汇合分析,较高的维生素D水平是指25-羟维生素D水平超过40ng/ml。“较高的25-羟维生素D浓度与包括乳腺癌、结肠癌、肺癌等在内的多种癌症风险降低有关。” 加州大学圣地亚哥分校医学院穆尔斯癌症中心公共卫生学博士Cedric Garland说道。“我和我的已故的哥哥

高维生素D水平可使癌症风险降低超过65%,该研究结果于4月6日发表在PLOS ONE。

上述结果来自一项随机试验和一项前瞻性队列研究的汇合分析,较高的维生素D水平是指25-羟维生素D水平超过40ng/ml。

“较高的25-羟维生素D浓度与包括乳腺癌、结肠癌、肺癌等在内的多种癌症风险降低有关。” 加州大学圣地亚哥分校医学院穆尔斯癌症中心公共卫生学博士Cedric Garland说道。

“我和我的已故的哥哥在20世纪80年代发现癌症主要是由维生素D缺乏引起的,就像维生素C缺乏导致坏血病一样,我们就开始对此进行研究。” Garland博士在接受Medscape 医学新闻采访时说。

Garland博士解释说,他是共同作者之一,来自内布拉斯加州奥马哈市克雷顿大学的Joan Lappe博士曾参与了一项随机对照临床试验(Am J Clin Nutr. 2007;85:1586-1591),正是该临床研究促使他们进行了这项汇合分析。

此前的研究发现随机分配每天接受1000IU维生素D的女性“各种癌症的发生率降低了77%”,他曾报道到。

“我们在2007年的时候发现,在女性人群中我们能够预防包括乳腺、肠道、肺部癌症在内的将近80%的癌症。令我震惊的是,我们已经了解这一点这么长时间,但是并没有人对此采取任何措施。我们决定让一部分研究对象摄入2000IU甚至更多的维生素D,我们的确得到了同样的结果。”他说。

Cedric Garland博士

Garland博士的团队汇合分析的数据来自两组人群:Lappe的研究对象为1169名女性,中位血清25(OH)D浓度为30ng/ml;GrassrootsHealth的研究对象为1135例女性,中位血清25(OH)D浓度为48ng/ml。

汇合研究中2304名女性的中位年龄为64岁(60-69岁),均为非西班牙裔白人,在进入研究时均无已知的癌症。


原始出处:

Sharon L. McDonnell , Carole Baggerly, Christine B. French, Leo L. Baggerly, Cedric F. Garland, Edward D. Gorham, Joan M. Lappe, Robert P. Heaney Serum 25-Hydroxyvitamin D Concentrations 40 ng/ml Are Associated with >65% Lower Cancer Risk: Pooled Analysis of Randomized Trial and Prospective Cohort Study PLoS One. 2016 Apr 6;11(4):e0152441. doi: 10.1371/journal.pone.0152441. eCollection 2016.

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    2016-10-06 1e10c84am36(暂无匿称)

    文章真心很好,感谢作者

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1789795, encodeId=8ff01e89795e5, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Thu Oct 06 04:10:00 CST 2016, time=2016-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=141014, encodeId=9a4d1410146f, content=文章真心很好,感谢作者, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Thu Oct 06 13:58:57 CST 2016, time=2016-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=139427, encodeId=c3dc13942eec, content=深度好文,值得关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Mon Oct 03 09:40:49 CST 2016, time=2016-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136776, encodeId=2a22136e76ef, content=如此低廉的癌症预防成本且如此高效,为什么没有大力临床推广?, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55a51936147, createdName=goddess 328, createdTime=Wed Sep 28 02:28:13 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79297, encodeId=f64be9297fc, content=有前途,试试, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e24e93173, createdName=丁丁医生2002, createdTime=Mon Apr 18 07:07:00 CST 2016, time=2016-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78817, encodeId=48e3e8817e9, content=买买买给长辈吃, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a6a1604604, createdName=Gsurgeon, createdTime=Sat Apr 16 22:25:00 CST 2016, time=2016-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78796, encodeId=f88fe879639, content=晒太阳, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK29w9r0upRgxUXHNhe7bd3VxHnhBSpibMbKOjtX92zXr78SkuZfUNuADrjHiaw6uibZaEYjh9cJLzew/132, createdBy=261e1682638, createdName=1de3b290m83(暂无匿称), createdTime=Sat Apr 16 20:20:00 CST 2016, time=2016-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78441, encodeId=d0d6e84412a, content=维生素D的研究生,普遍比较多。, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160313/IMG56E50DEC424F44672.jpg, createdBy=ce5b1699635, createdName=Lisa971, createdTime=Fri Apr 15 07:22:00 CST 2016, time=2016-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78398, encodeId=f2cde83988e, content=学习了长知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEJJAFMgSjibMicGVUgkmDBw4svXiccQxZicwjRHNxGPTghAmITxP12Rcmm0yFKfwGwUaiaUwpPUUUTOd2g/0, createdBy=fcd21609070, createdName=hekzn, createdTime=Thu Apr 14 22:06:00 CST 2016, time=2016-04-14, status=1, ipAttribution=)]
    2016-10-03 1e10c84am36(暂无匿称)

    深度好文,值得关注

    0

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    2016-09-28 goddess 328

    如此低廉的癌症预防成本且如此高效,为什么没有大力临床推广?

    0

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    2016-04-18 丁丁医生2002

    有前途,试试

    0

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    2016-04-16 Gsurgeon

    买买买给长辈吃

    0

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    2016-04-16 1de3b290m83(暂无匿称)

    晒太阳

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1789795, encodeId=8ff01e89795e5, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Thu Oct 06 04:10:00 CST 2016, time=2016-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=141014, encodeId=9a4d1410146f, content=文章真心很好,感谢作者, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Thu Oct 06 13:58:57 CST 2016, time=2016-10-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=139427, encodeId=c3dc13942eec, content=深度好文,值得关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Mon Oct 03 09:40:49 CST 2016, time=2016-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=136776, encodeId=2a22136e76ef, content=如此低廉的癌症预防成本且如此高效,为什么没有大力临床推广?, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55a51936147, createdName=goddess 328, createdTime=Wed Sep 28 02:28:13 CST 2016, time=2016-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=79297, encodeId=f64be9297fc, content=有前途,试试, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e24e93173, createdName=丁丁医生2002, createdTime=Mon Apr 18 07:07:00 CST 2016, time=2016-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78817, encodeId=48e3e8817e9, content=买买买给长辈吃, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a6a1604604, createdName=Gsurgeon, createdTime=Sat Apr 16 22:25:00 CST 2016, time=2016-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78796, encodeId=f88fe879639, content=晒太阳, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK29w9r0upRgxUXHNhe7bd3VxHnhBSpibMbKOjtX92zXr78SkuZfUNuADrjHiaw6uibZaEYjh9cJLzew/132, createdBy=261e1682638, createdName=1de3b290m83(暂无匿称), createdTime=Sat Apr 16 20:20:00 CST 2016, time=2016-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78441, encodeId=d0d6e84412a, content=维生素D的研究生,普遍比较多。, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160313/IMG56E50DEC424F44672.jpg, createdBy=ce5b1699635, createdName=Lisa971, createdTime=Fri Apr 15 07:22:00 CST 2016, time=2016-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=78398, encodeId=f2cde83988e, content=学习了长知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEJJAFMgSjibMicGVUgkmDBw4svXiccQxZicwjRHNxGPTghAmITxP12Rcmm0yFKfwGwUaiaUwpPUUUTOd2g/0, createdBy=fcd21609070, createdName=hekzn, createdTime=Thu Apr 14 22:06:00 CST 2016, time=2016-04-14, status=1, ipAttribution=)]
    2016-04-15 Lisa971

    维生素D的研究生,普遍比较多。

    0

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    2016-04-14 hekzn

    学习了长知识了

    0

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